1321 Evaluation of a new co-cultured microbiome ecosystem therapy candidate (MaaT03X) for clinical testing as adjuvant/neoadjuvant to immune checkpoint inhibitors in solid tumors

Autor: Emmanuel Prestat, Cyrielle Gasc, Carole Schwintner, Nathalie Corvaia, Bastien Laperrousaz, Julie Reygner, Charlotte Petitjean, Aurore Duquenoy, Lora Martin, Vincent Bonnaud, Marianne Robin, Sophie Declomesnil

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/4e9c03e8186f47e681affce73fb901d3

Table S1, Table S2, Table S3, Table S4, Figure S1Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7 from Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Autor: Nathalie Corvaia, Eric Chetaille, Mariya Pavlyuk, Cyrille Dreyfus, Michel Perez, Alain Beck, Jean-Francois Haeuw, Thierry Champion, Nicolas Boute, Martine Malissard, Charlotte Beau-Larvor, Alain Robert, Noureddine Loukili, Matthieu Broussas, Barbara Akla

Table S1 shows expression of IGF1R on human tissues Table S2 shows expression of IGF1R on Tumor and Normal cells Table S3 shows DAR calculation Table S4 shows impact of W0101 on cell cycle Figure S1 shows the flowchart for selection of m208F2 Figure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7311e3db6a545594f7793dd543bb27d1
https://doi.org/10.1158/1535-7163.22510686.v1

AJAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion

Autor: Daniel Kummer, Tim Steinbacher, Sonja Thölmann, Mariel Flavia Schwietzer, Christian Hartmann, Simone Horenkamp, Sabrina Demuth, Swetha S.D. Peddibhotla, Frauke Brinkmann, Björn Kemper, Jürgen Schnekenburger, Matthias Brandt, Timo Betz, Ivan Liashkovich, Ivan U. Kouzel, Victor Shahin, Nathalie Corvaia, Klemens Rottner, Katsiaryna Tarbashevich, Erez Raz, Lilo Greune, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet

Publikováno v: e202105147
Journal of Cell Biology

Contact inhibition of locomotion (CIL) is a process that regulates cell motility upon collision with other cells. Improper regulation of CIL has been implicated in cancer cell dissemination. Here, we identify the cell adhesion molecule JAM-A as a cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d836d502969abd1e01af4cd9dc022d
https://hdl.handle.net/11250/3061353

Abstract 4054: Development of a new site-specific sulfomaleimide rebridging platform for the generation of homogeneous, stable, potent and safe antibody drug conjugates

Autor: Alain Beck, Charlotte Beau-Larvor, Alain Batton, Laurence Zanna, Frédéric Marion, Sarah Cianférani, Philippe Maillos, Jean-François Haeuw, Marion Millet, Thierry Clerc, Barbara Akla, Martine Farrie, Marie-Claire Janin, Nathalie Corvaia, Cyrille Dreyfus, Celine Thuilliez

Publikováno v: Cancer Research. 80:4054-4054

There are currently 5 antibody drug conjugates (ADC) on the market and over 80 other ADCs evaluated in the clinic. The major drawbacks of the commonly employed bioconjugation methods based on nucleophilic coupling to lysine and cysteine are the non-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84227d4c67908831d0a23c267340584c
https://doi.org/10.1158/1538-7445.am2020-4054

Tumor cells hijack macrophage-produced complement C1q to promote tumor growth

Autor: Marina Botto, Imene Sakhi, Catherine Sautès-Fridman, Olivier Delfour, Stéphane Oudard, Xavier Cathelineau, Eric Chetaille, Cheng-Ming Sun, Virginie Verkarre, Florent Petitprez, Julie Meilleroux, Wolf H. Fridman, Marie V. Daugan, Nicolas S. Merle, Alexandre Passioukov, Rafael Sanchez-Salas, Janick Selves, Aurélien de Reyniès, Sonia Keddani, Bénédicte Le Clec'h, Nathalie Corvaia, Pierre Validire, Celine Thuilliez, Laetitia Lacroix, Nicolas A. Giraldo, Eric Barret, Lubka T. Roumenina, Yann Vano, Remi Noe, Arnaud Méjean, Etienne Becht, Pierre Ferré, Isabelle Vandenberghe

Publikováno v: Cancer Immunology Research
Cancer Immunology Research, American Association for Cancer Research, 2019, 7 (7), pp.1091-1105. ⟨10.1158/2326-6066.CIR-18-0891⟩

Clear-cell renal cell carcinoma (ccRCC) possesses an unmet medical need, particularly at the metastatic stage, when surgery is ineffective. Complement is a key factor in tissue inflammation, favoring cancer progression through the production of compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbc156528c0fedd3340fc996187e6e5
http://hdl.handle.net/10044/1/70575