Výsledky vyhledávání - "Nathalie Castéran"

Akademický článek

Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model.

Autor: Martine Humbert, Nathalie Castéran, Sébastien Letard, Katia Hanssens, Juan Iovanna, Pascal Finetti, François Bertucci, Thomas Bader, Colin D Mansfield, Alain Moussy, Olivier Hermine, Patrice Dubreuil

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9430 (2010)

BackgroundTyrosine kinases are attractive targets for pancreatic cancer therapy because several are over-expressed, including PDGFRalpha/beta, FAK, Src and Lyn. A critical role of mast cells in the development of pancreatic cancer has also been repor

Externí odkaz: https://doaj.org/article/c0ecd19186db4507849797a53ce894ca

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Akademický článek

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.

Autor: Patrice Dubreuil, Sébastien Letard, Marco Ciufolini, Laurent Gros, Martine Humbert, Nathalie Castéran, Laurence Borge, Bérengère Hajem, Anne Lermet, Wolfgang Sippl, Edwige Voisset, Michel Arock, Christian Auclair, Phillip S Leventhal, Colin D Mansfield, Alain Moussy, Olivier Hermine

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7258 (2009)

BackgroundThe stem cell factor receptor, KIT, is a target for the treatment of cancer, mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo profiles of masitinib (AB1010), a novel phenylaminothiazole-type tyrosine k

Externí odkaz: https://doaj.org/article/63537d296c7e47bf89a26c076d6d1533

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Selective Regulation of Human Immunodeficiency Virus-Infected CD4+Lymphocytes by a Synthetic Immunomodulator Leads to Potent Virus Suppression In Vitro and in hu-PBL-SCID Mice

Autor: Cécile Cocude, Edith Darcissac, Joëlle Dewulf, George M. Bahr, Marie-José Truong, Nathalie Castéran, Corinne Amiel, Yves Mouton, André Capron

Publikováno v: Journal of Virology. 75:6941-6952

Recent developments in antiretroviral therapy have led to substantial advances in the management of human immunodeficiency virus type 1 (HIV-1)-infected patients. However, it is becoming evident that potent antiretrovirals do not seem to be sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce068bb2145e2a0e9a653c9c87aae544
https://doi.org/10.1128/jvi.75.15.6941-6952.2001

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Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C / EBPβ and STAT1: role of CD14 and Toll-like receptors 2 and 4

Autor: Carrie J. Riendeau, Edith Darcissac, Nathalie Castéran, André Capron, Hardy Kornfeld, George M. Bahr, Vincent Vidal

Publikováno v: European Journal of Immunology. 31:1962-1971

The smallest unit of bacterial peptidoglycans known to be endowed with biological activities is muramyl dipeptide (MDP). A clinically acceptable synthetic derivative of MDP, namely murabutide (MB), has been found to present interesting pharmacologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00cfa0a883c2f7f89b5ce8be56734e6c
https://doi.org/10.1002/1521-4141(200107)31:7<1962::aid-immu1962>3.0.co

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