DNA Nanocarriers for Systemic Administration: Characterization and In Vivo Bioimaging in Healthy Mice

Autor: Stephanie David, Catherine Passirani, Nathalie Carmoy, Marie Morille, Mathieu Mevel, Benoit Chatin, Jean-Pierre Benoit, Tristan Montier, Bruno Pitard

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)

We hereby present different DNA nanocarriers consisting of new multimodular systems (MMS), containing the cationic lipid dioleylaminesuccinylparomomycin (DNA MMS DOSP), or bis (guanidinium)-tren-cholesterol (DNA MMS BGTC), and DNA lipid nanocapsules

Externí odkaz: https://doaj.org/article/0263947d11bb419787d8d6054ee080e0

Folate-equipped nanolipoplexes mediated efficient gene transfer into human epithelial cells

Autor: Tony Le Gall, Emmanuel Mornet, Céline Lainé, Pierre Lehn, Nathalie Carmoy, Tristan Montier, Remi Marianowski, Isabelle Laurent, Claude Férec, Thierry Benvegnu, Loïc Lemiègre

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2013, 14 (1), pp.1477-501. ⟨10.3390/ijms14011477⟩
Volume 14
Issue 1
Pages: 1477-1501
International Journal of Molecular Sciences, 2013, 14 (1), pp.1477-501. ⟨10.3390/ijms14011477⟩
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1477-1501 (2013)

International audience; Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c34ca2ac3d911559512c0e3aab4594
https://hal.archives-ouvertes.fr/hal-00811432

Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a human glioma model

Autor: Stephanie, David, Tristan, Montier, Nathalie, Carmoy, Pauline, Resnier, Anne, Clavreul, Mathieu, Mével, Bruno, Pitard, Jean-Pierre, Benoit, Catherine, Passirani

Publikováno v: The journal of gene medicine. 14(12)

We previously developed different types of DNA nanocarriers for systemic administration. Recently, the biodistribution profiles of these intravenously administered nanocarriers, DNA lipid nanocapsules (LNCs) and different multimodular systems (MMS),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d206b7fcd666fda8dd8488bd4d3d7fb
https://pubmed.ncbi.nlm.nih.gov/23143656

Cationic lipo-thiophosphoramidates for gene delivery: synthesis, physico-chemical characterization and gene transfection activity--comparison with lipo-phosphoramidates

Autor: Jean-Pierre Haelters, Pierre Lehn, Laure Burel-Deschamps, Damien Loizeau, Tristan Montier, Philippe Giamarchi, Hélène Couthon-Gourvès, Paul-Alain Jaffrès, Nathalie Carmoy, Tony Le Gall, Aurore Fraix

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2011, 9 (7), ⟨10.1039/C0OB00981D⟩

International audience; The synthesis of cationic lipo-thiophosphoramidates, a new family of cationic lipids designed for gene delivery, is reported herein. This new class of lipids is less polar than its oxygenated equivalent the lipo-phosphoramidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4439cf9c4ffa6e01181a8a57f653017
https://pubmed.ncbi.nlm.nih.gov/21321786

Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting

Autor: Priscille Brodin, Nathalie Carmoy, Marie Morille, Jean-Pierre Benoit, Catherine Passirani, Bruno Pitard, Pierre Legras, Tristan Montier

Publikováno v: Biomaterials
Biomaterials, Elsevier, 2010, 31 (2), pp.321-329. ⟨10.1016/j.biomaterials.2009.09.044⟩
Biomaterials, Elsevier, 2010, 31 (2), pp.321-9. ⟨10.1016/j.biomaterials.2009.09.044⟩

International audience; Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encaps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b83a899a5581a516f7ea0e8b3bc40c
https://pubmed.ncbi.nlm.nih.gov/19800113