Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nathalie Barrett"'
Autor:
Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological
Externí odkaz:
https://doaj.org/article/82c3864e38134c29b42485f93454e6e6
Autor:
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz:
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
Autor:
Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz:
https://doaj.org/article/554910ddac3e4c48ab605416698c2ab9
Autor:
Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/b87abd360cbe4242978c39198c55f937
Autor:
Andrew D. Roberts, Bhumika Karamshi, Angela Bridges, Hawa Diallo, Chun-wa Chung, Kelly Locke, Peter D. Craggs, Darren Jason Mitchell, Paul Bamborough, Amanda Emmons, Christopher Roland Wellaway, Emma J. Jones, David P. Dixon, Robert J. Watson, Nathalie Barrett, Emmanuel Hubert Demont, Clement Douault, Robert J. Sheppard, Rab K. Prinjha, Rebecca C. Furze, Anne-Marie Michon, Paola Grandi, Bernadette Mouzon
Publikováno v:
Journal of medicinal chemistry. 58(14)
Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb3845b766f600c6cb136aa5e1eb88a
https://pubmed.ncbi.nlm.nih.gov/26155854
https://pubmed.ncbi.nlm.nih.gov/26155854
Autor:
Raymond Kabo, Marc-André Bourgault, Jean François Bissonnette, Nathalie Barrette, Louis Tanguay
Publikováno v:
Hydrology, Vol 10, Iss 6, p 130 (2023)
Research in hydrological sciences is constantly evolving to provide adequate answers to address various water-related issues. Methodological approaches inspired by mathematical and physical sciences have shaped hydrological sciences from its inceptio
Externí odkaz:
https://doaj.org/article/90155fe9344b4d478c062fd9ad7e9c39
Autor:
Champa Patel, Brian Hayes, Janet L. Smith, Andrew P. Fosberry, Nathalie Barrett, Joanne McKenary, Nicola J. Richmond, Angela Bridges, Jessica Vamathevan, Bernadette Mouzon, Sundip Modha, Chun-wa Chung, Anshu Bhardwaja, Rachel Grimley, Roberto Solari, Oxana Polyakova
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
PLoS ONE
PLoS ONE
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063885b383c1c58685a6763d5df1c06
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792191/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792191/pdf/?tool=EBI
Autor:
Emmanuel H. Demont, Chun-wa Chung, RebeccaC. Furze, Paola Grandi, Anne-Marie Michon, Chris Wellaway, Nathalie Barrett, Angela M. Bridges, PeterD. Craggs, Hawa Diallo, David P. Dixon, Clement Douault, Amanda J. Emmons, EmmaJ. Jones, Bhumika V. Karamshi, Kelly Locke, Darren J. Mitchell, BernadetteH. Mouzon, Rab K. Prinjha, Andy D. Roberts
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5649-5673, 25p