Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Nathalie Alépée"'
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The Organization for Economic Co-operation and Development (OECD) Guidance Document No. 34 and No. 286 on Good In Vitro Method Practices (GIVIMPs) for the development and implementation of in vitro methods for regulatory use in human safety assessmen
Externí odkaz:
https://doaj.org/article/867cd7cce47e45699130fba052b36e2b
Autor:
Rodrigo De Vecchi, Vanja Dakic, Guilherme Mattos, Anne-Sophie Rigaudeau, Veronica Oliveira, Cristina Garcia, Nathalie Alépée, José Cotovio, Charbel Bouez
Publikováno v:
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, Vol 6, Iss 1 (2018)
Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019. As a result, the interest for validated alternative testing methods for
Externí odkaz:
https://doaj.org/article/36bc1303d18d47f98d1d3242ec820d5e
Autor:
Lizao, Chen, Fang, Huang, CaiChun, Kei, Jinsong, Zhang, Jing, Sang, Ying, Yang, Rong, Kuang, Xikun, Xiong, Qing, Li, Yanfeng, Liu, Qin, Qin, E, Zhao, Nathalie, Alépée, Gladys, Ouedraogo, Nan, Li, Zhenzi, Cai
Publikováno v:
Mutagenesis. 37:173-181
A novel in vitro 3D micronucleus assay was developed in China using the EpiSkin™ 3D human skin model. This EpiSkin™ Micronucleus Assay showed good predictivity and reproducibility during internal validation and is expected to contribute to in vit
Publikováno v:
Applied In Vitro Toxicology. 7:91-101
Introduction: Cosmetics Europe develops two defined approaches (DAs) for eye hazard identification, that is, addressing serious eye damage (Cat. 1), eye irritation (Cat. 2), and the absence thereof...
Autor:
Sebastian Hoffmann, Nathalie Alépée, Nicola Gilmour, Petra S. Kern, Erwin van Vliet, Fanny Boislève, Dagmar Bury, Elodie Cloudet, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Karsten Mewes, Masaaki Miyazawa, Hayato Nishida, Mai Thanh Tam Brami, Mustafa Varçin, Anne Marie Api, Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 131
The assessment of skin sensitisation is a key requirement in all regulated sectors, with the European Union's regulation of cosmetic ingredients being most challenging, since it requires quantitative skin sensitisation assessment based on new approac
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 81
Limitations of the applicability domain of new approach methodologies (NAM) present a major challenge for the testing of cosmetic ingredients in Europe, as the regulation does not allow to resort to in vivo test method. Therefore, research focused on
Autor:
Silvia Teissier, Nathalie Alépée, Ann Detroyer, Thierry Pauloin, C. Piroird, L. Nardelli, Aurélia Del Bufalo, Hicham Noçairi, Fleur Tourneix, Joan Eilstein
Publikováno v:
Toxicology in Vitro. 60:134-143
Skin sensitization is an important toxicological endpoint in the safety assessment of chemicals and cosmetic ingredients. Driven by ethical considerations and European Union (EU) legislation, its assessment has progressed from the reliance on traditi
Autor:
Isabelle Lee, Mihwa Na, Devin O'Brien, Rahul Parakhia, Nathalie Alépée, Walter Westerink, Irene Eurlings, Anne Marie Api
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 79
The U-SENS™ assay was developed to address the third key event of the skin sensitization adverse outcome pathway (AOP) and is described in OECD test guideline 442E, Annex II. A dataset of 68 fragrance ingredients comprised of 7 non-sensitizers and
Autor:
Tyler Peryea, Ahsan Habib Polash, Alessandra Roncaglioni, Daniel M. Wilson, Warren Casey, Patricia Ruiz, Nathalie Alépée, Sherif Farag, Giovanna J. Lavado, Kimberley M. Zorn, Alexey V. Zakharov, Davide Ballabio, Katrina M. Waters, Risa Sayre, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nicole Kleinstreuer, Pankaj R. Daga, Sean Ekins, Kamel Mansouri, Liguo Wang, Judy Strickland, Matthew J. Hirn, Sudin Bhattacharya, Dac-Trung Nguyen, Emilio Benfenati, Ignacio J. Tripodi, Amanda K. Parks, Garett Goh, Dennis G. Thomas, Glenn J. Myatt, Prachi Pradeep, Gergely Zahoranszky-Kohalmi, Anton Simeonov, Arthur C. Silva, Grace Patlewicz, Timothy Sheils, Stephen Boyd, Agnes L. Karmaus, Ahmed Sayed, Alex M. Clark, Todd M. Martin, Pavel Karpov, Jeffery M. Gearhart, Robert Rallo, D Allen, Charles Siegel, Zhen Zhang, Zijun Xiao, Alexander Tropsha, Stephen J. Capuzzi, Alexandru Korotcov, Carolina Horta Andrade, Noel Southall, Viviana Consonni, Igor V. Tetko, Jeremy M. Fitzpatrick, Andrew J. Wedlake, Denis Fourches, Zhongyu Wang, Vinicius M. Alves, Eugene N. Muratov, Timothy E. H. Allen, Andrea Mauri, James B. Brown, Alexandre Varnek, Yun Tang, Sanjeeva J. Wijeyesakere, Daniel P. Russo, Cosimo Toma, Christopher M. Grulke, Michael S. Lawless, Domenico Gadaleta, Paritosh Pande, Thomas Hartung, Jonathan M. Goodman, Kristijan Vukovic, Joyce V. Bastos, Daniela Trisciuzzi, Fagen F. Zhang, Domenico Alberga, Thomas Luechtefeld, Dan Marsh, Tyler R. Auernhammer, Shannon M. Bell, Xinhao Li, Brian J. Teppen, F. Lunghini, Sergey Sosnin, Hao Zhu, Feng Gao, Craig Rowlands, Tongan Zhao, R Todeschini, Valery Tkachenko, Francesca Grisoni, Hongbin Yang, Yaroslav Chushak, Maxim V. Fedorov, Heather L. Ciallella, Gilles Marcou
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10be9a3f401d14e1b5653e1242ab66
https://www.repository.cam.ac.uk/handle/1810/322114
https://www.repository.cam.ac.uk/handle/1810/322114
Autor:
Marie-Hélène Grandidier, Mariko Yokota, Els Adriaens, Daiki Kyoutani, Daisuke Yoshida, Nathalie Alépée, Virginie Leblanc, José Cotovio
Publikováno v:
Toxicology in Vitro. 54:202-214
Assessment of ocular irritation risk is an international regulatory requirement in the safety evaluation of products. In response to this need, L'Oréal developed the SkinEthic™ Human Corneal Epithelium (HCE) Eye Irritation Test (EIT) that has been