Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Nathalie Alépée"'
Autor:
Robin Gradin, Fleur Tourneix, Ulrika Mattson, Johan Andersson, Frédéric Amaral, Andy Forreryd, Nathalie Alépée, Henrik Johansson
Publikováno v:
Toxics, Vol 12, Iss 9, p 626 (2024)
Toxicological assessments of skin sensitizers have progressed towards a higher reliance on non-animal methods. Current technological trends aim to extend the utility of non-animal methods to accurately characterize skin-sensitizing potency. The GARDs
Externí odkaz:
https://doaj.org/article/92418fb6e0854056a382987a83024b46
Publikováno v:
Toxics, Vol 12, Iss 8, p 536 (2024)
Regulations of cosmetic ingredients and products have been the most advanced in embracing new approach methodologies (NAMs). Consequently, the cosmetic industry has assumed a forerunner role in the development and implementation of animal-free next-g
Externí odkaz:
https://doaj.org/article/670759854f9346a3a9fd7e48ad4b2c04
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The Organization for Economic Co-operation and Development (OECD) Guidance Document No. 34 and No. 286 on Good In Vitro Method Practices (GIVIMPs) for the development and implementation of in vitro methods for regulatory use in human safety assessmen
Externí odkaz:
https://doaj.org/article/867cd7cce47e45699130fba052b36e2b
Autor:
Lizao, Chen, Fang, Huang, CaiChun, Kei, Jinsong, Zhang, Jing, Sang, Ying, Yang, Rong, Kuang, Xikun, Xiong, Qing, Li, Yanfeng, Liu, Qin, Qin, E, Zhao, Nathalie, Alépée, Gladys, Ouedraogo, Nan, Li, Zhenzi, Cai
Publikováno v:
Mutagenesis. 37:173-181
A novel in vitro 3D micronucleus assay was developed in China using the EpiSkin™ 3D human skin model. This EpiSkin™ Micronucleus Assay showed good predictivity and reproducibility during internal validation and is expected to contribute to in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a2e860d8e43064c453ac45444e3c85
https://doi.org/10.1093/mutage/geac014
https://doi.org/10.1093/mutage/geac014
Autor:
Rodrigo De Vecchi, Vanja Dakic, Guilherme Mattos, Anne-Sophie Rigaudeau, Veronica Oliveira, Cristina Garcia, Nathalie Alépée, José Cotovio, Charbel Bouez
Publikováno v:
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, Vol 6, Iss 1 (2018)
Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019. As a result, the interest for validated alternative testing methods for
Externí odkaz:
https://doaj.org/article/36bc1303d18d47f98d1d3242ec820d5e
Publikováno v:
Applied In Vitro Toxicology. 7:91-101
Introduction: Cosmetics Europe develops two defined approaches (DAs) for eye hazard identification, that is, addressing serious eye damage (Cat. 1), eye irritation (Cat. 2), and the absence thereof...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac8885aa271fa6570f14cf77ad3b7db
https://doi.org/10.1089/aivt.2021.0012
https://doi.org/10.1089/aivt.2021.0012
Autor:
Sebastian Hoffmann, Nathalie Alépée, Nicola Gilmour, Petra S. Kern, Erwin van Vliet, Fanny Boislève, Dagmar Bury, Elodie Cloudet, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Karsten Mewes, Masaaki Miyazawa, Hayato Nishida, Mai Thanh Tam Brami, Mustafa Varçin, Anne Marie Api, Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 131
The assessment of skin sensitisation is a key requirement in all regulated sectors, with the European Union's regulation of cosmetic ingredients being most challenging, since it requires quantitative skin sensitisation assessment based on new approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67436f07a0169ef82f6ae0d2319ed98a
https://pubmed.ncbi.nlm.nih.gov/35447229
https://pubmed.ncbi.nlm.nih.gov/35447229
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 81
Limitations of the applicability domain of new approach methodologies (NAM) present a major challenge for the testing of cosmetic ingredients in Europe, as the regulation does not allow to resort to in vivo test method. Therefore, research focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9955930a02f81f5f80ef2672715b356
https://pubmed.ncbi.nlm.nih.gov/35346800
https://pubmed.ncbi.nlm.nih.gov/35346800
Autor:
Isabelle Lee, Mihwa Na, Devin O'Brien, Rahul Parakhia, Nathalie Alépée, Walter Westerink, Irene Eurlings, Anne Marie Api
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 79
The U-SENS™ assay was developed to address the third key event of the skin sensitization adverse outcome pathway (AOP) and is described in OECD test guideline 442E, Annex II. A dataset of 68 fragrance ingredients comprised of 7 non-sensitizers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979f1ffe126875ecf854ab06ca4658e7
https://pubmed.ncbi.nlm.nih.gov/34902536
https://pubmed.ncbi.nlm.nih.gov/34902536
Autor:
Silvia Teissier, Nathalie Alépée, Ann Detroyer, Thierry Pauloin, C. Piroird, L. Nardelli, Aurélia Del Bufalo, Hicham Noçairi, Fleur Tourneix, Joan Eilstein
Publikováno v:
Toxicology in Vitro. 60:134-143
Skin sensitization is an important toxicological endpoint in the safety assessment of chemicals and cosmetic ingredients. Driven by ethical considerations and European Union (EU) legislation, its assessment has progressed from the reliance on traditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a32b55f948ff069d343fef29814592
https://doi.org/10.1016/j.tiv.2019.05.008
https://doi.org/10.1016/j.tiv.2019.05.008