Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Nathalie Lamarche-vane"'
Autor:
Jun Matsuda, Dina Greenberg, Sajida Ibrahim, Mirela Maier, Lamine Aoudjit, Jennifer Chapelle, Cindy Baldwin, Yi He, Nathalie Lamarche-Vane, Tomoko Takano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Rho GTPases are regulators of the actin cytoskeleton and their activity is modulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchanging factors (GEFs). Glomerular podocytes have numerous actin-based projections called foo
Externí odkaz:
https://doaj.org/article/de5dcb43431a4e55a53ad493899f32c8
Autor:
Yi He, Marie-Anne Goyette, Jennifer Chapelle, Nadia Boufaied, Jalal Al Rahbani, Maribel Schonewolff, Eric I. Danek, William J. Muller, David P. Labbé, Jean-François Côté, Nathalie Lamarche-Vane
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112936- (2023)
Summary: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in metastasis, which is the leading cause of death in breast cancer patients. Here, we show that Cdc42 GTPase-activating protein (CdGAP) promotes tumor formation and metastasis
Externí odkaz:
https://doaj.org/article/99945987e095410c96e9de7bda1ae234
Autor:
Chahat Mehra, Ji-Hyun Chung, Yi He, Mónica Lara-Márquez, Marie-Anne Goyette, Nadia Boufaied, Véronique Barrès, Véronique Ouellet, Karl-Phillippe Guérard, Carine Delliaux, Fred Saad, Jacques Lapointe, Jean-François Côté, David P. Labbé, Nathalie Lamarche-Vane
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orth
Externí odkaz:
https://doaj.org/article/90e48f7b139747d6ba6e98b737476318
Autor:
Jenna Giubilaro, Doris A. Schuetz, Tomasz M. Stepniewski, Yoon Namkung, Etienne Khoury, Mónica Lara-Márquez, Shirley Campbell, Alexandre Beautrait, Sylvain Armando, Olivier Radresa, Jean Duchaine, Nathalie Lamarche-Vane, Audrey Claing, Jana Selent, Michel Bouvier, Anne Marinier, Stéphane A. Laporte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
While Ras is a promising target for cancer therapy, development of inhibitors targeting Ras signaling has proven challenging. Here, the authors report the discovery of Rasarfin, a small molecule from a phenotypic screen on G protein-coupled receptor
Externí odkaz:
https://doaj.org/article/ec44bf6899064e34b2049b207a9e9931
Autor:
Margaret F. Lippincott, Wanxue Xu, Abigail A. Smith, Xinyu Miao, Agathe Lafont, Omar Shennib, Gordon J. Farley, Riwa Sabbagh, Angela Delaney, Maria Stamou, Lacey Plummer, Kathryn Salnikov, Neoklis A. Georgopoulos, Veronica Mericq, Richard Quinton, Frederic Tran Mau-Them, Sophie Nambot, Asma Hamad, Helen Brittain, Rebecca S. Tooze, Eduardo Calpena, Andrew O.M. Wilkie, Marjolaine Willems, William F. Crowley, Ravikumar Balasubramanian, Nathalie Lamarche-Vane, Erica E. Davis, Stephanie B. Seminara
Publikováno v:
Genetics in Medicine. 24:2501-2515
The study aimed to identify novel genes for idiopathic hypogonadotropic hypogonadism (IHH).A cohort of 1387 probands with IHH underwent exome sequencing and de novo, familial, and cohort-wide investigations. Functional studies were performed on 2 p19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3cce5412ed78cc1a00576d2114ea97
https://doi.org/10.1016/j.gim.2022.08.025
https://doi.org/10.1016/j.gim.2022.08.025
Autor:
Martin H. Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F. Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L. Michaud, Graziella Di Cristo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to c
Externí odkaz:
https://doaj.org/article/eeb13416b0ae4f06aee639606c693a20
Autor:
Fred Saad, Jacques Lapointe, Yi He, Mónica Lara-Márquez, Nathalie Lamarche-Vane, David P. Labbé, Jean-François Côté, Ji-Hyun Chung, Nadia Boufaied, Karl-Phillippe Guérard, Chahat Mehra, Marie-Anne Goyette, Carine Delliaux, Veronique Ouellet, Véronique Barrès
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
High mortality of prostate cancer patients is primarily due to metastasis. Understanding the mechanisms controlling metastatic processes remains essential to develop novel therapies designed to prevent the progression from localized disease to metast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1acccf8572ae8061a98d6ae3c29b97
https://doaj.org/article/90e48f7b139747d6ba6e98b737476318
https://doaj.org/article/90e48f7b139747d6ba6e98b737476318
Autor:
Katherine Stewart, Yaned Gaitan, Maxwell E R Shafer, Lamine Aoudjit, Di Hu, Richa Sharma, Mathieu Tremblay, Hidetaka Ishii, Michael Marcotte, Daniela Stanga, You Chi Tang, Sami Kamel Boualia, Alana H T Nguyen, Tomoko Takano, Nathalie Lamarche-Vane, Silvia Vidal, Maxime Bouchard
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005785 (2016)
Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins
Externí odkaz:
https://doaj.org/article/0eda3a3522f8409a988741c49533c6d0
Publikováno v:
Cancer Letters. 483:98-113
Liver metastases remain a major cause of death from gastrointestinal tract cancers and other malignancies, such as breast and lung carcinomas. Understanding the underlying biology is essential for the design of effective therapies. We previously iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9b5709b13e3b60326f1b150c55f5b1
https://doi.org/10.1016/j.canlet.2020.03.018
https://doi.org/10.1016/j.canlet.2020.03.018
Autor:
David Castillo-Azofeifa, Tomas Wald, Efren A. Reyes, Aaron Gallagher, Julia Schanin, Stephanie Vlachos, Nathalie Lamarche-Vane, Carolyn Bomidi, Sarah Blutt, Mary K. Estes, Todd Nystul, Ophir D. Klein
Publikováno v:
Cell Stem Cell. 30:188-206.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d9e36ce879ef5bfcca778523f6badef
https://doi.org/10.1016/j.stem.2022.12.008
https://doi.org/10.1016/j.stem.2022.12.008