Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Nathalie Barrett"'
1
Akademický článek
Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes
Autor: Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological
Externí odkaz: https://doaj.org/article/82c3864e38134c29b42485f93454e6e6
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2
Akademický článek
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
Autor: Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz: https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
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3
Akademický článek
Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.
Autor: Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz: https://doaj.org/article/554910ddac3e4c48ab605416698c2ab9
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6
Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses
Autor: Champa Patel, Brian Hayes, Janet L. Smith, Andrew P. Fosberry, Nathalie Barrett, Joanne McKenary, Nicola J. Richmond, Angela Bridges, Jessica Vamathevan, Bernadette Mouzon, Sundip Modha, Chun-wa Chung, Anshu Bhardwaja, Rachel Grimley, Roberto Solari, Oxana Polyakova
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e39847 (2012)
PLoS ONE
SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063885b383c1c58685a6763d5df1c06
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792191/pdf/?tool=EBI
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