Lipid emulsion interfacial design modulates human in vivo digestion and satiation hormone response

Autor: Pascal Bertsch, Andreas Steingoetter, Myrtha Arnold, Nathalie Scheuble, Jotam Bergfreund, Shahana Fedele, Dian Liu, Helen L. Parker, Wolfgang Langhans, Jens F. Rehfeld, Peter Fischer

Publikováno v: Bertsch, P, Steingoetter, A, Arnold, M, Scheuble, N, Bergfreund, J, Fedele, S, Liu, D, Parker, H L, Langhans, W, Rehfeld, J F & Fischer, P 2022, ' Lipid emulsion interfacial design modulates human in vivo digestion and satiation hormone response ', Food and Function, vol. 13, no. 17, pp. 9010-9020 . https://doi.org/10.1039/d2fo01247b
Food & Function, 13 (171)

Lipid emulsions (LEs) with tailored digestibility have the potential to modulate satiation or act as delivery systems for lipophilic nutrients and drugs. The digestion of LEs is governed by their interfacial emulsifier layer which determines their ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab22491059955576aa049d894b5d0f37
https://doi.org/10.1039/d2fo01247b

Mechanically Enhanced Liquid Interfaces at Human Body Temperature Using Thermosensitive Methylated Nanocrystalline Cellulose

Autor: Raffaele Mezzenga, Erich J. Windhab, Thomas Geue, Peter Fischer, Nathalie Scheuble, Jozef Adamcik, Simon Kuster

Publikováno v: Langmuir

The mechanical performance of materials at oil/water interfaces after consumption is a key factor affecting hydrophobic drug release. In this study, we methylated the surface of nanocrystalline cellulose (NCC) by mercerization and dimethyl sulfate ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2480ba611005b8d3ee270502b6f325c2

Tailoring Emulsions for Controlled Lipid Release: Establishing in vitro-in Vivo Correlation for Digestion of Lipids

Autor: Nathalie Scheuble, Helen L. Parker, Andreas Steingoetter, Erich J. Windhab, Manuel Schumacher, Peter Fischer, Dian Liu, Joschka Schaffner

Publikováno v: ACS applied materialsinterfaces. 10(21)

The use of oil-in-water emulsions for controlled lipid release is of interest to the pharmaceutical industry in the development of poorly water soluble drugs and also has gained major interest in the treatment of obesity. In this study, we focus on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bee5fc4658628382f42029e1af922e
https://pubmed.ncbi.nlm.nih.gov/29708724

Tailored Interfacial Rheology for Gastric Stable Adsorption Layers

Autor: Erich J. Windhab, Peter Fischer, Nathalie Scheuble, Thomas Geue

Publikováno v: Biomacromolecules

Human lipid digestion begins at the interface of oil and water by interfacial adsorption of lipases. Tailoring the available surface area for lipase activity can lead to specific lipid sensing in the body, thus, tailored satiety hormone release. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290fa9ef5f290156d366ff8fa94ad6d4
https://doi.org/10.1021/bm500767c

Simultaneous Control of pH and Ionic Strength during Interfacial Rheology of β-Lactoglobulin Fibrils Adsorbed at Liquid/Liquid Interfaces

Autor: Nathalie Scheuble, Erich J. Windhab, Patrick A. Rühs, Raffaele Mezzenga, Peter Fischer

Publikováno v: Langmuir

Proteins can aggregate as amyloid fibrils under denaturing and destabilizing conditions such as low pH (2) and high temperature (90 °C). Fibrils of β-lactoglobulin are surface active and form adsorption layers at fluid-fluid interfaces. In this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beec16d88e1bac3ea1f14236210745d
https://doi.org/10.1021/la3026705