Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Nathalie, Rufer"'
Autor:
Julien Schmidt, Johanna Chiffelle, Marta A. S. Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume, Michael Hebeisen, Olivier Michielin, Tu Nguyen-Ngoc, Florian Huber, Melita Irving, Stéphanie Tissot-Renaud, Brian J. Stevenson, Sylvie Rusakiewicz, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Nathalie Rufer, David Gfeller, Lana E. Kandalaft, Daniel E. Speiser, Vincent Zoete, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities o
Externí odkaz:
https://doaj.org/article/07eeb33e654749ddb84ed54edf7d260f
Autor:
Barbara Couturaud, Bastien Doix, Laura Carretero-Iglesia, Mathilde Allard, Sylvain Pradervand, Michael Hebeisen, Nathalie Rufer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of v
Externí odkaz:
https://doaj.org/article/0bda0ac473c242f7b564903799614b19
Autor:
Petra Baumgaertner, Julien Schmidt, Carla-Marisa Costa-Nunes, Natacha Bordry, Philippe Guillaume, Immanuel Luescher, Daniel E. Speiser, Nathalie Rufer, Michael Hebeisen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated trimeric TCR-peptide:HLA complex, the molecular binding affinities betwe
Externí odkaz:
https://doaj.org/article/898c9211d61e4be5922842459750bbc5
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studie
Externí odkaz:
https://doaj.org/article/f611af4ae501422cbc012cdd8ddf0721
Autor:
Stéphanie Bibert, Nicolas Guex, Joao Lourenco, Thomas Brahier, Matthaios Papadimitriou-Olivgeris, Lauro Damonti, Oriol Manuel, Robin Liechti, Lou Götz, Jonathan Tschopp, Mathieu Quinodoz, Peter Vollenweider, Jean-Luc Pagani, Mauro Oddo, Olivier Hügli, Frédéric Lamoth, Véronique Erard, Cathy Voide, Mauro Delorenzi, Nathalie Rufer, Fabio Candotti, Carlo Rivolta, Noémie Boillat-Blanco, Pierre-Yves Bochud, the RegCOVID Study Group, Bochud Pierre-Yves, Desgranges Florian, Filippidis Paraskevas, Guéry Benoit, Haefliger David, Kampouri Eleftheria-Evdokia, Manuel Oriol, Munting Aline, Pagani Jean-Luc, Papadimitriou-Olivgeris Matthaios, Regina Jean, Rochat-Stettler Laurence, Suttels Veronique, Tadini Eliana, Tschopp Jonathan, Van Singer Mathias, Viala Benjamin, Vollenweider Peter
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly
Externí odkaz:
https://doaj.org/article/031b1be15a7044fbb009c5558ae5426c
Autor:
Aurelia Zimmerli, Matteo Monti, Craig Fenwick, Isabella Eckerle, Catherine Beigelman-Aubry, Céline Pellaton, Katia Jaton, Dominique Dumas, Gian-Marco Stamm, Laura Infanti, Heidrun Andreu-Ullrich, Daphné Germann, Marie Mean, Peter Vollenweider, Raphael Stadelmann, Maura Prella, Denis Comte, Benoit Guery, David Gachoud, Nathalie Rufer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In these times of COVID-19 pandemic, concern has been raised about the potential effects of SARS-CoV-2 infection on immunocompromised patients, particularly on those receiving B-cell depleting agents and having therefore a severely depressed humoral
Externí odkaz:
https://doaj.org/article/0cf550ff4e204822b68e266ddda4c7de
Autor:
Mathilde Gavillet, Nathalie Rufer, Francesco Grandoni, Mattia Rizzi, Nicolas Vulliemoz, David Baud, Lorenzo Alberio, Giorgia Canellini, Hélène Legardeur
Publikováno v:
British Journal of Haematology. 201:581-584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c913aab99c175fa6d6c003d95a8fb7f9
https://doi.org/10.1111/bjh.18741
https://doi.org/10.1111/bjh.18741
Autor:
David Gachoud, Trestan Pillonel, Gerasimos Tsilimidos, Dunia Battolla, Dominique Dumas, Onya Opota, Stefano Fontana, Peter Vollenweider, Oriol Manuel, Gilbert Greub, Claire Bertelli, Nathalie Rufer
Publikováno v:
British Journal of Haematology. 199:549-559
Administration of plasma therapy may contribute to viral control and survival of COVID-19 patients receiving B-cell-depleting agents that impair humoral immunity. However, little is known on the impact of anti-CD20 pre-exposition on the kinetics of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480f25c0cdef9e1a03a42a50ca85a006
https://doi.org/10.1111/bjh.18450
https://doi.org/10.1111/bjh.18450
Autor:
Laura Carretero-Iglesia, Barbara Couturaud, Petra Baumgaertner, Julien Schmidt, Hélène Maby-El Hajjami, Daniel E. Speiser, Michael Hebeisen, Nathalie Rufer
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols selecting for tumor-specific T-cells of hi
Externí odkaz:
https://doaj.org/article/2cd5a9b56a1141f9a7d739b8297833b1
Autor:
Pedro Romero, Camilla Jandus, Dietmar Zehn, Alena Donda, Nathalie Rufer, Daniel E. Speiser, Gwennaëlle Monnot, Laura Carretero-Iglesia, Santiago J. Carmona, Lorenzo F. Sempere, Amaia Martinez-Usatorre
Table S2. Statistical tests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eff1fd202b4ad4249b1cd241f540dba
https://doi.org/10.1158/2326-6066.22542385.v1
https://doi.org/10.1158/2326-6066.22542385.v1
