Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma

Autor: Christelle Vincent-Fabert, Lilian Roland, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont

Publikováno v: Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-8 (2019)

Abstract Escape from immune control must be important in the natural course of B-cell lymphomas, especially for those with activation of NF-κB. The pre-clinical LMP1/CD40-expressing transgenic mouse model is characterized by B-cell specific CD40 sig

Externí odkaz: https://doaj.org/article/cd01d7a2d5e64de0b73fc172f309afea

c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study

Autor: Nathalie Faumont, Oussama Taoui, Davi Collares, Jean-Philippe Jais, Karen Leroy, Léa Prévaud, Fabrice Jardin, Thierry J. Molina, Christiane Copie-Bergman, Barbara Petit, Marie-Pierre Gourin, Dominique Bordessoule, Danielle Troutaud, Véronique Baud, Jean Feuillard

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activ

Externí odkaz: https://doaj.org/article/cc5e9e2c17bf4d2bb3dc4179c7dae410

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells

Autor: Amandine David, Nicolas Arnaud, Magali Fradet, Hélène Lascaux, Catherine Ouk-Martin, Nathalie Gachard, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont

Publikováno v: Haematologica, Vol 102, Iss 5 (2017)

While c-Myc dysregulation is constantly associated with highly proliferating B-cell tumors, nuclear factor (NF)-κB addiction is found in indolent lymphomas as well as diffuse large B-cell lymphomas, either with an activated B-cell like phenotype or

Externí odkaz: https://doaj.org/article/2bdea7433ec941de88401744e3e458f5

Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells

Autor: Karl Balabanian, Jean Feuillard, Isabelle Soubeyran, Christelle Oblet, David Rizzo, Nathalie Faumont, Stéphanie Poulain, Marie Parrens, Catherine Ouk, Nathalie Gachard, Lilian Roland, Alexis Saintamand, Morgane Thomas, Marion Espéli, Quentin Lemasson, Christelle Vincent-Fabert, Claire Carrion, Mélanie Boulin

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, 12, pp.641692. ⟨10.3389/fimmu.2021.641692⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.641692. ⟨10.3389/fimmu.2021.641692⟩
Frontiers in Immunology, Vol 12 (2021)

Activating mutations of MYD88 (MYD88L265P being the far most frequent) are found in most cases of Waldenström macroglobulinemia (WM) as well as in various aggressive B-cell lymphoma entities with features of plasma cell (PC) differentiation, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6c552fdc9b5ee96335b6e06dd19096
https://hal.science/hal-03429361

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

Autor: Nathalie Faumont, Anne Marchalot, Jean-Marie Lambert, François Boyer, Laurent Delpy, Jean Feuillard, Justine Pollet, Jeanne Cook-Moreau

The need to identify new therapeutic approaches to the treatment of cancers of the B lymphoid lineage is crucial. Unlike CRISPR/Cas technology, antisense strategies result in transient modifications of gene expression and lack mutagenic effects at th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fcbccd09f7ac75b7184a19a389ed0de
https://doi.org/10.1101/2020.09.18.302984