Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Nathalie, Dhomen"'
Autor:
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Precision medicine needs prognostic markers to select the patients that will benefit more from targeted therapy. Authors show here that high level of baseline T cell receptor diversity is an indicator of favourable prognosis in multiple cancer types,
Externí odkaz:
https://doaj.org/article/5580ae6b92b14a67a7ff151b6081830b
Autor:
Piyushkumar A. Mundra, Nathalie Dhomen, Manuel Rodrigues, Lauge Hjorth Mikkelsen, Nathalie Cassoux, Kelly Brooks, Sara Valpione, Jorge S. Reis-Filho, Steffen Heegaard, Marc-Henri Stern, Sergio Roman-Roman, Richard Marais
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Mucosal melanomas are not thought to be UV radiation (UVR)-driven, yet some present UVR-related mutations. Here the authors show that some mucosal melanomas, especially conjunctival, present mutations characteristic of UVR exposure, yet share structu
Externí odkaz:
https://doaj.org/article/f6fb21383af743c491f2b948dc8a807b
Autor:
Elena Galvani, Piyushkumar A. Mundra, Sara Valpione, Pablo Garcia-Martinez, Matthew Smith, Jonathan Greenall, Rohit Thakur, Beth Helmink, Miles C. Andrews, Louis Boon, Christopher Chester, Gabriela Gremel, Kate Hogan, Amit Mandal, Kang Zeng, Antonia Banyard, Garry Ashton, Martin Cook, Paul Lorigan, Jennifer A. Wargo, Nathalie Dhomen, Richard Marais
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Identification of clinical relevant biomarkers to predict response to immune checkpoint blockade (ICB) in melanoma remains challenging. Here, the authors show that stroma remodelling and reduced cell division are associated with durable response to a
Externí odkaz:
https://doaj.org/article/a043c3f4d304486f94686720bc3b8706
Autor:
Sara Valpione, Luca G. Campana, John Weightman, Zena Salih, Elena Galvani, Piyushkumar A. Mundra, Francesco De Rosa, Avinash Gupta, Patricio Serra-Bellver, Paul Lorigan, Theodora Germetaki, Marek Dynowski, Stephen Kitcatt, Sudhakar Sahoo, Dave Lee, Nathalie Dhomen, Graham Lord, Richard Marais
Publikováno v:
European Journal of Cancer. 177:164-174
Immune cell-driven anti-cancer activity is paramount for effective responses to checkpoint inhibitors (ICB). However, the contribution of the different immune cell subsets in the circulation and within the tumour is poorly understood.To elucidate the
Autor:
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/8faeb08e7f524ade9a071857a7bbd388
Autor:
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent si
Externí odkaz:
https://doaj.org/article/1e8df04e596541cea30f865991c28ab1
Autor:
Richard Marais, Caroline Dive, Paul Lorigan, Ged Brady, Nathalie Dhomen, Deemesh Oudit, Alberto Fusi, Matthew Smith, Jacqueline Swan, Jane Rogan, Malin Pedersen, Franziska Baenke, Simon J. Furney, Grazia Saturno, Kok Haw Jonathan Lim, Amit Kumar Mandal, Amaya Viros, Dominic Rothwell, Elena Galvani, Rebecca Lee, Gabriela Gremel, Maria Romina Girotti
40 Gene Miseq primers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5814132d325f0455f16950de381c5fe4
https://doi.org/10.1158/2159-8290.22531439.v1
https://doi.org/10.1158/2159-8290.22531439.v1
Autor:
Richard Marais, Caroline Dive, Paul Lorigan, Ged Brady, Nathalie Dhomen, Deemesh Oudit, Alberto Fusi, Matthew Smith, Jacqueline Swan, Jane Rogan, Malin Pedersen, Franziska Baenke, Simon J. Furney, Grazia Saturno, Kok Haw Jonathan Lim, Amit Kumar Mandal, Amaya Viros, Dominic Rothwell, Elena Galvani, Rebecca Lee, Gabriela Gremel, Maria Romina Girotti
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a80fee60399dc89e1e38bb601f2a4c9
https://doi.org/10.1158/2159-8290.22531451
https://doi.org/10.1158/2159-8290.22531451
Autor:
Claudia Wellbrock, Richard Marais, Jennifer A. Wargo, Zachary A. Cooper, Dennie T. Frederick, Keith T. Flaherty, Nathalie Dhomen, Helen Young, Jennifer Ferguson, Holly Brunton, Kate O'Brien, Berta Sanchez-Laorden, Michael P. Smith
Supplementary Figures S1 - S9, Table S1. Supplementary Figure S1 (related to Figure 1) shows TNFR expression in melanoma cells. Supplementary Figure S2 (related to Figure 2) shows an NF-κBα binding site in the MITF promoter and MITF target gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eebe97e7f237a40460c891e401cfbbf
https://doi.org/10.1158/2159-8290.22530828
https://doi.org/10.1158/2159-8290.22530828
Autor:
Richard Marais, Caroline Dive, Paul Lorigan, Ged Brady, Nathalie Dhomen, Deemesh Oudit, Alberto Fusi, Matthew Smith, Jacqueline Swan, Jane Rogan, Malin Pedersen, Franziska Baenke, Simon J. Furney, Grazia Saturno, Kok Haw Jonathan Lim, Amit Kumar Mandal, Amaya Viros, Dominic Rothwell, Elena Galvani, Rebecca Lee, Gabriela Gremel, Maria Romina Girotti
Supplementary Figure S1. IGV visualization for whole exome sequencing of codon Q61 of NRAS in the pre-treatment tumor vs. the relapsed tumor in patient 1. The red color indicates the A>G for the p.Q61R mutation in the tumor. Supplementary Figure S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb45bc18f1fa31ff6c106fd96139cb1
https://doi.org/10.1158/2159-8290.22531454.v1
https://doi.org/10.1158/2159-8290.22531454.v1