Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge

Autor: Weronika Wozniak, Emmanuel Sechet, Yong-Jun Kwon, Nathalie Aulner, Lionel Navarro, Brice Sperandio

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract The human intestinal tract is colonized with microorganisms, which present a diverse array of immunological challenges. A number of antimicrobial mechanisms have evolved to cope with these challenges. A key defense mechanism is the expressio

Externí odkaz: https://doaj.org/article/cf79cfe5f1da4cb685383c00d8a9efa6

A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.

Autor: Alexandra Maure, Emeline Lawarée, Francesco Fiorentino, Alexandre Pawlik, Saideep Gona, Alexandre Giraud-Gatineau, Matthew J G Eldridge, Anne Danckaert, David Hardy, Wafa Frigui, Camille Keck, Claude Gutierrez, Olivier Neyrolles, Nathalie Aulner, Antonello Mai, Mélanie Hamon, Luis B Barreiro, Priscille Brodin, Roland Brosch, Dante Rotili, Ludovic Tailleux

Publikováno v: PLoS Biology, Vol 22, Iss 4, p e3002259 (2024)

Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresistant strains of Mycobacterium tuberculosis (MTB) are constantly emerging. Innovati

Externí odkaz: https://doaj.org/article/e2eedf80218b48f79d34efc207ddd2fb

Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

Autor: Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B. Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L. Shorte, Brigitte David-Watine, the Milieu Intérieur Consortium, Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Trouvier, Marie-Noëlle Ungeheuer, Darragh Duffy, Matthew L. Albert, Lluis Quintana-Murci

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Externí odkaz: https://doaj.org/article/f5411277a03049e5bd53c9d75c9fdf2e

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response

Autor: Hervé Lecoeur, Eric Prina, Thibault Rosazza, Kossiwa Kokou, Paya N’Diaye, Nathalie Aulner, Hugo Varet, Giovanni Bussotti, Yue Xing, Geneviève Milon, Robert Weil, Guangxun Meng, Gerald F. Späth

Publikováno v: Cell Reports, Vol 30, Iss 6, Pp 1870-1882.e4 (2020)

Summary: Aberrant macrophage activation during intracellular infection generates immunopathologies that can cause severe human morbidity. A better understanding of immune subversion strategies and macrophage phenotypic and functional responses is nec

Externí odkaz: https://doaj.org/article/03a73a3a577e418ca6b357c79f82d753

Identification of antiviral molecules against West-Nile virus by an approach combining cell imaging and equine neural cells derived from induced-pluripotent stem cells

Autor: Marielle Cochet-Bernoin, François Piumi, Kamila Gorna, Gaelle Gonzalez, Anne Danckaert, Nathalie Aulner, Hélène Munier-Lehmann, Stephan Zientara, Xavier Donadeu, F., Alexandra Benchoua, Muriel Coulpier

Publikováno v: International Equine Infectious Diseases Conference 2021-IEIDC XI
International Equine Infectious Diseases Conference 2021-IEIDC XI, Sep 2021, DEAUVILLE, France
Journées Scientifiques et Doctorales de l'Anses (JSDA) 2021
Journées Scientifiques et Doctorales de l'Anses (JSDA) 2021, Sep 2021, MAISONS-ALFORT, France
HAL

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::078115f925323acd3542aecb1f6e6612
https://hal.inrae.fr/hal-03355807