Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nathalia Moraes de Vasconcelos"'
Autor:
Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107959- (2020)
Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell de
Externí odkaz:
https://doaj.org/article/6779e405188049e5968e638fabda95f5
Autor:
Rosa Martín-Pérez, Mohamed Lamkanfi, Hanne Van Gorp, Nina Van Opdenbosch, Annalisa Zecchin, Peter Vandenabeele, Nathalia Moraes de Vasconcelos
Publikováno v:
Cell Reports
CELL REPORTS
Cell Reports, Vol 32, Iss 4, Pp 107959-(2020)
CELL REPORTS
Cell Reports, Vol 32, Iss 4, Pp 107959-(2020)
Summary Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2bac2607aafa7f8fcbd51f78796d10
https://doi.org/10.2139/ssrn.3528687
https://doi.org/10.2139/ssrn.3528687
Autor:
Ingrid De Meester, Anne-Marie Lambeir, Gwendolyn Vliegen, Anvesh Jallapally, Ruth Geiss-Friedlander, Mohamed Lamkanfi, Nina Van Opdenbosch, Pieter Van der Veken, Rosa Martín-Pérez, Emilie De Hert, Amanda Gonçalves, Nathalia Moraes de Vasconcelos, Koen Augustyns
Publikováno v:
LIFE SCIENCE ALLIANCE
Life Science Alliance
Life Science Alliance
This study shows that caspase-1 autocleavage, ASC speck assembly, and mature IL-1β and IL-18 secretion accompany rapid DPP8/DPP9-regulated pyroptosis induction in macrophages expressing a LeTx-responsive Nlrp1b allele.
Activating germline mutat
Activating germline mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3d744e62583c0ad6d59fba497e54e
https://biblio.ugent.be/publication/8600762/file/8600764
https://biblio.ugent.be/publication/8600762/file/8600764
Publikováno v:
Cellular and Molecular Life Sciences. 73:2335-2347
Inflammasomes are multi-protein platforms that are organized in the cytosol to cope with pathogens and cellular stress. The pattern recognition receptors NLRP1, NLRP3, NLRC4, AIM2 and Pyrin all assemble canonical platforms for caspase-1 activation, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1d52dfbb1f605920669ee016af03ff
https://doi.org/10.1007/s00018-016-2204-3
https://doi.org/10.1007/s00018-016-2204-3
Autor:
Melissa Dullaers, Filip Van Hauwermeiren, Mohamed Lamkanfi, Nathalia Moraes de Vasconcelos, Tino Hochepied, Dieter Demon, Jo Dehoorne, Lieselotte Vande Walle, Delfien Bogaert, Hanne Van Gorp, Fabrizio De Benedetti, Pedro Henrique Viana Saavedra, Elfride De Baere, Giusi Prencipe, Karim Vermaelen, Antonella Insalaco, Filomeen Haerynck, Magdalena Matusiak, Nina Van Opdenbosch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(50)
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It is caused by mutations in the inflammasome adaptor Pyrin, but how FMF mutations alter signaling in FMF patients is unknown. Herein, we establish Cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e06f35deea4000d7cfef774562e43e3
https://pubmed.ncbi.nlm.nih.gov/27911804
https://pubmed.ncbi.nlm.nih.gov/27911804
Autor:
Stefan Krautwald, Amanda Gonçalves, Mohamed Lamkanfi, Lieselotte Vande Walle, Pedro Henrique Viana Saavedra, Nathalia Moraes de Vasconcelos, Thirumala-Devi Kanneganti, Filip Van Hauwermeiren, Jinke D’Hont, Dieter Demon, Tino Hochepied, Hanne Van Gorp, Maarten Verdonckt, Magdalena Matusiak, Nina Van Opdenbosch
Publikováno v:
Cell Reports
CELL REPORTS
Cell Reports, Vol 21, Iss 12, Pp 3427-3444 (2017)
CELL REPORTS
Cell Reports, Vol 21, Iss 12, Pp 3427-3444 (2017)
Summary The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb533065ab7cf28d6b31fdd0d946d94
Autor:
Eef Parthoens, Mohamed Lamkanfi, Hanne Van Gorp, Nina Van Opdenbosch, Nathalia Moraes de Vasconcelos
Publikováno v:
Cell Death & Differentiation
CELL DEATH AND DIFFERENTIATION
Cell Death and Differentiation
CELL DEATH AND DIFFERENTIATION
Cell Death and Differentiation
Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1 beta and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac26563c96ee0c3e04336230d9dfbc4
Publikováno v:
Nina Van Opdenbosch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::4f8bb0f2c1247999acc67c2f66104ed7
Publikováno v:
Cold Spring Harbor Perspectives in Biology
Cold Spring Harb Perspect Biol
Cold Spring Harb Perspect Biol
Inflammasomes assemble in the cytosol of myeloid and epithelial cells on sensing of cellular stress and pathogen-associated molecular patterns and serve as scaffolds for recruitment and activation of inflammatory caspases. Inflammasomes play benefici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1428379dd07d39a69390b59c62dca593