Study on the regioselectivity of the N-ethylation reaction of N-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Autor: Pedro N. Batalha, Maria Cecília B. V. de Souza, Nathalia M. C. Tolentino, Fernanda da C. S. Boechat, Luana da S. M. Forezi, José Walkimar de M. Carneiro, Ednilsom Orestes, Maria Clara R. Freitas

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 388-400 (2019)

4-Oxoquinolines are a class of organic substances of great importance in medicinal chemistry, due to their biological and synthetic versatility. N-1-Alkylated-4-oxoquinoline derivatives have been associated with different pharmacological activities s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f404ebaf8c30ab061b9c0b46a343e61
http://europepmc.org/articles/PMC6404479

Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives : finding new potential Aaticancer drugs

Autor: Maria Eduarda I.M. Oliveira, Alessandra Mendonça Teles de Souza, Raquel Carvalho Montenegro, Vitor F. Ferreira, Riethe De Oliveira, Rommel Rodríguez Burbano, Luana da S. M. Forezi, Rafael Ferreira Dantas, Maria Cecília B. V. de Souza, Bárbara Abrahim-Vieira, Leilane H. Barreto, Helena Carla Castro, Floriano P. Silva, Anna C. Cunha, Fernanda da C. S. Boechat, Nathalia M. C. Tolentino

Publikováno v: Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Molecules; Volume 19; Issue 5; Pages: 6651-6670
Molecules
Molecules, Vol 19, Iss 5, Pp 6651-6670 (2014)

As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f9d3ccd23e5a3cc850dc6b5434a6e2
http://www.repositorio.ufc.br/handle/riufc/9540