An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

Autor: Leena Halim, Marco Romano, Reuben McGregor, Isabel Correa, Polychronis Pavlidis, Nathali Grageda, Sec-Julie Hoong, Muhammed Yuksel, Wayel Jassem, Rosalind F. Hannen, Mark Ong, Olivia Mckinney, Bu’Hussain Hayee, Sophia N. Karagiannis, Nicholas Powell, Robert I. Lechler, Estefania Nova-Lamperti, Giovanna Lombardi

Publikováno v: Cell Reports, Vol 20, Iss 3, Pp 757-770 (2017)

Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses. Here, we characterized T helper (Th)-like Treg subsets to further delineate their biol

Externí odkaz: https://doaj.org/article/ac5022db56944e29b0db055e9ca4656e

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Autor: Anke Fuchs, Mateusz Gliwiński, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhäuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Gołab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grześ, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H.G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sánchez-Ramón, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M. U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski

Publikováno v: Frontiers in Immunology, Vol 8 (2018)

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medi

Externí odkaz: https://doaj.org/article/6e6307c0ff3e4a65bfd0edfff5a979c4

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

Autor: Katie Lowe, Kathryn J. Wood, Paul N. Harden, Cristiano Scottà, Giovanna Lombardi, Sarah Thirkell, Niloufar Safinia, Laura J. Fry, Robert I. Lechler, Henrieta Fraser, Andrew Hope, Nathali Grageda, A. Bushell, Christopher D. Fisher, Rachel Hilton, David Game

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 198-209 (2018)
Fraser, H, Safinia, N, Grageda, N, Thirkell, S, Lowe, K, Fry, L J, Scottá, C, Hope, A, Fisher, C, Hilton, R, Game, D, Harden, P, Bushell, A, Wood, K, Lechler, R I & Lombardi, G 2018, ' A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials ', Molecular Therapy-Methods and Clinical Development, vol. 8, pp. 198-209 . https://doi.org/10.1016/j.omtm.2018.01.006
Molecular Therapy. Methods & Clinical Development

The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell therapy requires production processes that satisfy the rigors of Good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c7dfa095434a871f936184ee7a6363
http://www.sciencedirect.com/science/article/pii/S232905011830007X

Applicability, Safety And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation

Autor: Jakia Ali, Marc Martinez-Llordella, Julie Heward, Gillian Lewis, Mike Lyne, Alex Kerr, Juan José Lozano, Sarah Thirkell, Andrew Hope, Shahram Kordasti, Nigel Heaton, Laura J. Fry, Christopher D. Fisher, Farzin Farzaneh, Elisavet Kodela, Marco Romano, Katie Lowe, Matthew E. Cramp, Giovanna Lombardi, Irene Rebollo-Mesa, Nathali Grageda, Tiong Yeng Lim, Gavin Whitehouse, Alberto Sanchez-Fueyo, Robert I. Lechler, Niloufar Safinia

Publikováno v: Sánchez-Fueyo, A, Whitehouse, G, Grageda, N, Cramp, M E, Lim, T Y, Romano, M, Thirkell, S, Lowe, K, Fry, L, Heward, J, Kerr, A, Ali, J, Fisher, C, Lewis, G, Hope, A, Kodela, E, Lyne, M, Farzaneh, F, Kordasti, S, Rebollo-Mesa, I, Jose Lozano, J, Safinia, N, Lechler, R, Martínez-Llordella, M & Lombardi, G 2019, ' Applicability, Safety And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation ', American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . https://doi.org/10.1111/ajt.15700
American Journal of Transplantation

Regulatory T cells (Tregs) are a lymphocyte subset with intrinsic immunosuppressive properties that can be expanded in large numbers ex vivo and have been shown to prevent allograft rejection and promote tolerance in animal models. To investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a54488df2eaa3cf32b7e166de186a9e
https://kclpure.kcl.ac.uk/ws/files/119194108/S_nchez_Fueyo_et_al_2019_American_Journal_of_Transplantation_1_.pdf

Novel approach to recognition of predicted HIV-1 Gag B3501-restricted CD8 T-cell epitopes by HLA-B3501(+) patients: confirmation by quantitative ELISpot analyses and characterisation using multimers

Autor: Nathali Grageda, Samantha J. Westrop, Nesrina Imami

Publikováno v: Journal of immunological methods. 341(1-2)

Exploring the intricacies of CD8(+) T-cell epitope recognition using emerging technologies to combine assessment of affinity, phenotype and resulting polyfunctional efficacy advances our understanding of HIV-1 immunopathogenesis and disease progressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9974a029af1e14defdc286e7ece08ee1
https://pubmed.ncbi.nlm.nih.gov/19056394