Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Natella Maglakelidze"'
Autor:
Natella Maglakelidze, Samantha L. Gettle, Amy L. Longenecker, Allison T. Vidimos, Elizabeth M. Billingsley, Ryan P. Hobbs, Charlene Lam
Publikováno v:
JID Innovations, Vol 4, Iss 5, Pp 100288- (2024)
Smoothened inhibitors, such as vismodegib, exhibit remarkable success in treating patients with locally advanced basal cell carcinoma (LaBCC). Yet, vismodegib efficacy is hindered by notable side effects, which often lead to treatment discontinuation
Externí odkaz:
https://doaj.org/article/237d0ac69a9d487f9f8b69b2b137a12b
Autor:
Jeffrey R. Brender, Julian C. Assmann, Don E. Farthing, Keita Saito, Shun Kishimoto, Kathrynne A. Warrick, Natella Maglakelidze, Terri L. Larus, Hellmut Merkle, Ronald E. Gress, Murali C. Krishna, Nataliya P. Buxbaum
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract In vivo deuterated water (2H2O) labeling leads to deuterium (2H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer cells wou
Externí odkaz:
https://doaj.org/article/4c8119b013a14979bcb9adbcb1a54649
Publikováno v:
Pulmonary Therapy, Vol 6, Iss 2, Pp 169-176 (2020)
Abstract Introduction COVID-19 presentation may include a profound increase in cytokines and associated pneumonia, rapidly progressing to acute respiratory distress syndrome (ARDS). This so-called cytokine storm often leads to refractory edema, respi
Externí odkaz:
https://doaj.org/article/2510dfc5a3fd47e8ae5e8c5023413193
Autor:
Don E. Farthing, Nataliya P. Buxbaum, Philip J. Lucas, Natella Maglakelidze, Brittany Oliver, Jiun Wang, Kevin Hu, Ehydel Castro, Catherine V. Bare, Ronald E. Gress
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo
Externí odkaz:
https://doaj.org/article/d4a83883366a4094aed2ee20a95b6681
Autor:
Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1971-1980.e8 (2019)
Summary: Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle pro
Externí odkaz:
https://doaj.org/article/43188544f0f744368b8635d3e2d2aa3b
Disparities in health care coverage, chronic diseases, mental health, and mortality among racial and ethnic groups, incarcerated individuals, and low-income communities are prevalent in the United States (U.S.). There is a need to address these short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d028fd05232bc361fb60ac463fba513
https://doi.org/10.21203/rs.3.rs-2468731/v1
https://doi.org/10.21203/rs.3.rs-2468731/v1
Publikováno v:
The Journal of investigative dermatology.
Alopecia areata (AA) is an autoimmune hair loss disorder with no cure. Patients with sequence variation in AIRE are 15 times more likely to develop AA than the general population, yet the roles of AIRE in AA pathogenesis are unknown. In this study, w
Publikováno v:
Pulmonary Therapy
Pulmonary Therapy, Vol 6, Iss 2, Pp 169-176 (2020)
Pulmonary Therapy, Vol 6, Iss 2, Pp 169-176 (2020)
Introduction COVID-19 presentation may include a profound increase in cytokines and associated pneumonia, rapidly progressing to acute respiratory distress syndrome (ARDS). This so-called cytokine storm often leads to refractory edema, respiratory ar
Autor:
Julian C. Assmann, Shun Kishimoto, Jeffrey R. Brender, Don E. Farthing, Ronald E. Gress, Hellmut Merkle, Natella Maglakelidze, Daniel R. Crooks, Murali C. Krishna, Nataliya P. Buxbaum, Keita Saito, Kathrynne A. Warrick
Water is an essential component of many biochemical reactions. Deuterated water (D2O) has been used to study cell kinetics, protein synthesis, and metabolism. We hypothesized that rapidly proliferating cancer cells would become preferentially labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d3be90c5415e1b09a40ce61849605b0
https://doi.org/10.1101/809327
https://doi.org/10.1101/809327
Autor:
Mary T. Doan, Katherine M. Aird, Michael Zaleski, Raghavendra Gowda, Holly A. Lacko, Meenhard Herlyn, Gao Zhang, Raquel Buj, Natella Maglakelidze, Yiling Lu, Ross Kuskovsky, Maithili Navaratnarajah, Nathaniel W. Snyder, Gavin P. Robertson, Helen Jiang, Chi-Wei Chen, David J. DeGraff, Kelly E. Leon, Lydia Kutzler, Yuka Imamura, Erika S. Dahl, Joshua I. Warrick, Gordon B. Mills, Scot R. Kimball
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1971-1980.e8 (2019)
SummaryReprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle progr