Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Natee Jearawiriyapaisarn"'
Autor:
Phitchapa Pongpaksupasin, Pirut Tong-Ngam, Natee Jearawiriyapaisarn, Kittiphong Paiboonsukwong, Siripakorn Sangkitporn, Adisak Trinavarat, Alisa Tubsuwan, La-Ongsri Atchaneeyasakul
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103448- (2024)
Mutations in the eyes shut homolog (EYS) gene are one of the common causes of autosomal recessive retinitis pigmentosa (RP). The lack of suitable animal models hampers progress understanding of the disease mechanism and drug development. This study r
Externí odkaz:
https://doaj.org/article/3273ffd9fb6c4cfaae40779c7c245672
Autor:
Tipparat Penglong, Apisara Saensuwanna, Husanai Jantapaso, Pongpon Phuwakanjana, Natee Jearawiriyapaisarn, Kittiphong Paiboonsukwong, Worrawit Wanichsuwan, Kanitta Srinoun
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/0fd99b07e992478ba4604265fc15bef4
Autor:
Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyapaisarn, Suthat Fucharoen, Chayanon Peerapittayamongkol
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281059 (2023)
Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches. Genome-wide association studies h
Externí odkaz:
https://doaj.org/article/8e464e9501f443a9a400fe86ec02f049
Autor:
Phitchapa Pongpaksupasin, Wasinee Wongkummool, Pirut Tong-Ngam, Natee Jearawiriyapaisarn, Kittiphong Paiboonsukwong, Siripakorn Sangkitporn, Adisak Trinavarat, La-Ongsri Atchaneeyasakul, Alisa Tubsuwan
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102964- (2022)
Choroideremia (CHM) is a monogenic, X-linked inherited retinal disease caused by mutations in the CHM gene. CHM patients develop progressive loss of vision due to degeneration of cell layers in the retina. In this report, the human-induced pluripoten
Externí odkaz:
https://doaj.org/article/0594a0a3b2ce4e36beb82bda828beb0a
Autor:
Orapan Sripichai, Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Tiwaporn Nualkaew, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn
Publikováno v:
Hematology Reports, Vol 13, Iss 4 (2021)
Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin gen
Externí odkaz:
https://doaj.org/article/f4f7685b6a5e43a99dd8c5878570edf6
Autor:
Sharon A. Singh, Yu Wang, Lei Yu, Takashi Moriguchi, Chia Jui Ku, Julien Pedron, Masayuki Yamamoto, Michael G. Rosenfeld, John H. Bushweller, Greggory Myers, Natee Jearawiriyapaisarn, James Douglas Engel, Rami Khoriaty, Andrew White, Kim-Chew Lim, Emily Schneider
Publikováno v:
Blood. 138:1691-1704
Histone H3 lysine 4 methylation (H3K4Me) is most often associated with chromatin activation, and removing H3K4 methyl groups has been shown to be coincident with gene repression. H3K4Me demethylase KDM1a/LSD1 is a therapeutic target for multiple dise
Publikováno v:
Human Gene Therapy. 32:473-480
Restoration of correct splicing of βIVS2-654-globin pre-mRNA was previously accomplished in erythroid cells from β-thalassemia/HbE patients by an engineered U7 small nuclear RNA (snRNA) that carrie...
Autor:
Nurmeeha Hinna, Orapan Sripichai, Suthat Fucharoen, Pranee Winichagoon, Tiwaporn Nualkaew, Nattrika Buasuwan, Thongperm Munkongdee, Saovaros Svasti, Natee Jearawiriyapaisarn, Kittiphong Paiboonsukwong
Publikováno v:
International Journal of Laboratory Hematology. 42:727-733
INTRODUCTION Several DNA-based approaches including a reverse dot-blot hybridization (RDB) have been established for detection of β-thalassemia genotypes to provide accurate genetic counseling and prenatal diagnosis for prevention and control of sev
Autor:
Pinyaphat Khamphikham, Suradej Hongeng, James Douglas Engel, Natee Jearawiriyapaisarn, Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Duantida Songdej, Suthat Fucharoen, Kittiphong Paiboonsukwong, Tiwaporn Nualkaew, Orapan Sripichai
Publikováno v:
Annals of Hematology. 99:2027-2036
Increased expression of fetal hemoglobin (HbF) improves the clinical severity of β-thalassemia patients. EHMT1/2 histone methyltransferases are epigenetic modifying enzymes that are responsible for catalyzing addition of the repressive histone mark
Autor:
Lei Yu, Greggory Myers, Emily Schneider, Yu Wang, Raven Mathews, Kim Chew Lim, David Siemieniak, Vi Tang, David Ginsburg, Ginette Balbin-Cuesta, Sharon A. Singh, Pongpon Phuwakanjana, Natee Jearawiriyapaisarn, Rami Khoriaty, James Douglas Engel
Publikováno v:
Blood advances. 6(11)
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these fetal genes in adult red blood cells can ameliorate man