Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Natassja G. Bush"'
Publikováno v:
Molecules, Vol 25, Iss 23, p 5662 (2020)
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase
Externí odkaz:
https://doaj.org/article/2974e7bcf3454ec993d26d40a63b7d7d
Autor:
Thomas RM Germe, Natassja G Bush, Victoria M Baskerville, Dominik Saman, Justin LP Benesch, Anthony Maxwell
Publikováno v:
eLife, Vol 12 (2024)
DNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex. DNA gyrase can loop DNA around the C-terminal domains (CTDs) of GyrA and pass o
Externí odkaz:
https://doaj.org/article/818a8c392608434c80a580bc63164796
Autor:
Thomas Germe, Natassja G. Bush, Victoria Baskerville, Dominik Saman, Justin Benesch, Anthony Maxwell
DNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the active complex. GyrA is usually found as a dimer in solution, whereas GyrB can exist as a monom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b7d4be0676256f04e719d0dad89e45
https://doi.org/10.7554/elife.86722.1
https://doi.org/10.7554/elife.86722.1
Publikováno v:
Molecules, Vol 25, Iss 5662, p 5662 (2020)
Molecules
Molecules
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a3056480a1380b9fc85fd6d86a419b
https://www.mdpi.com/1420-3049/25/23/5662
https://www.mdpi.com/1420-3049/25/23/5662
Publikováno v:
The Biochemist. 40:26-31
DNA topoisomerases have been described as ‘the magicians of the DNA world’, somehow allowing DNA strands to pass through each other. These ingenious enzymes are both essential and potentially dangerous, as any interruption in their DNA breakage-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90eebcbe02682329bc2adf8c26f1137f
https://doi.org/10.1042/bio04002026
https://doi.org/10.1042/bio04002026
Autor:
Peter B. Madrid, Kamel Djaout, Victoria Katawera, Hannu Myllykallio, Natassja G. Bush, Hubert F. Becker, Sean Ekins, Stephen J. Hearnshaw, Vinayak Singh, Valerie Mizrahi, Yap Boum, Anthony Maxwell, Pauline Bourbon, Jennifer E. Pritchard
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27792. ⟨10.1038/srep27792⟩
There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year. We have targeted two essential enzymes in this organism th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763f239d7bcb00db373cb3988355ece1
https://hal.sorbonne-universite.fr/hal-01332296
https://hal.sorbonne-universite.fr/hal-01332296
Publikováno v:
Journal of Thermal Biology. 33:404-412
Thermoregulatory responses are known to differ seasonally in endotherms and this is often dependent on the environment and region they are resident. Holarctic animals are exposed to severe winters and substantial seasonal variation in ambient tempera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66490d6328d5991f140d69c0331515f
https://doi.org/10.1016/j.jtherbio.2008.06.005
https://doi.org/10.1016/j.jtherbio.2008.06.005
Publikováno v:
EcoSal Plus. 6(2)
DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d333abbd7d86bf6e765726303292388
https://pubmed.ncbi.nlm.nih.gov/26435256
https://pubmed.ncbi.nlm.nih.gov/26435256
Autor:
Natassja G. Bush, László Őrfi, Ruben C. Hartkoorn, László Kékesi, Adwait Anand Godbole, Katarína Mikušová, György Kéri, Anthony Maxwell, Zuzana Svetlíková, János Pató, Stewart T. Cole, Csaba Szántai-Kis, Valakunja Nagaraja, Anna Sipos, Jana Korduláková, Rita Székely, Frédéric Collin
Publikováno v:
IndraStra Global.
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fff1f81b2dcba388155a20b6edf4779
https://igi.indrastra.com/items/show/190186
https://igi.indrastra.com/items/show/190186