Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Autor: Natasja W M Ramnath, Koen M van de Luijtgaarden, Ingrid van der Pluijm, Menno van Nimwegen, Paula M van Heijningen, Sigrid M A Swagemakers, Bibi S van Thiel, Ruziedi Y Ridwan, Nicole van Vliet, Marcel Vermeij, Luuk J A C Hawinkels, Anne de Munck, Oleh Dzyubachyk, Erik Meijering, Peter van der Spek, Robbert Rottier, Hiromi Yanagisawa, Rudi W Hendriks, Roland Kanaar, Ellen V Rouwet, Alex Kleinjan, Jeroen Essers

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106054 (2014)

BackgroundIn this study we set out to investigate the clinically observed relationship between chronic obstructive pulmonary disease (COPD) and aortic aneurysms. We tested the hypothesis that an inherited deficiency of connective tissue might play a

Externí odkaz: https://doaj.org/article/54e4a897fc8f4940a384b4aa95d8a42b

A case of right ventricular outflow tract obstruction after minimally invasive aortic valve replacement

Autor: Natasja W. M. Ramnath, H. Ibrahim Ozdemir, Mohamed A. Soliman-Hamad

Publikováno v: Journal of Cardiac Surgery. 34:626-627

Minimally invasive aortic valve replacement is commonly used to treat aortic valve disease through smaller incisions and upper hemisternotomy. No major differences in postoperative outcomes have been reported compared with full sternotomy aortic valv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36f740f5dc6545d5094b8911e7b65e3b
https://doi.org/10.1111/jocs.14093

Fibulin-4 deficiency increases TGF-beta signalling in aortic smooth muscle cells due to elevated TGF-beta 2 levels

Autor: L. te Riet, Ahj Danser, Madelon Paauwe, P. ten Dijke, Marcel Vermeij, P.M. van Heijningen, Natasja W. M. Ramnath, Roland Kanaar, Lukas J. A. C. Hawinkels, Jeroen Essers

Publikováno v: Scientific Reports, 5. Nature Publishing Group
Scientific Reports, 5
Scientific Reports

Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db2390f3f2dc0465ff12f856df00a58
https://pure.eur.nl/en/publications/8749d96c-648a-4e2b-99b0-a0ecb04ebf19

Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade

Autor: Els Moltzer, Stephanie Lankhorst, Sigrid M. A. Swagemakers, Angelique M. Bouhuizen, Peter J. van der Spek, A.H. Jan Danser, Natasja W. M. Ramnath, Dirk J. Duncker, Marcel Vermeij, Luuk te Riet, Ellen V. Rouwet, Richard van Veghel, Monique C. de Waard, Jeroen Essers, Joep H.M. van Esch, Paula M. van Heijningen

Publikováno v: PLoS ONE
PLoS One (print), 6(8). Public Library of Science
Moltzer, E, Riet, L T, Swagemakers, S M A, van Heijningen, P M, Vermeij, M, van Veghel, R, Bouhuizen, A M, van Esch, J H M, Lankhorst, S, Ramnath, N W M, de Waard, M C, Duncker, D J, van der Spek, P J, Rouwet, E V, Danser, A H J & Essers, J 2011, ' Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT(1)) Receptor Blockade ', PLoS ONE, vol. 6, no. 8, e23411 . https://doi.org/10.1371/journal.pone.0023411
PLoS ONE, Vol 6, Iss 8, p e23411 (2011)
PLoS ONE, 6(8):e23411. Public Library of Science

Medial degeneration is a key feature of aneurysm disease and aortic dissection. In a murine aneurysm model we investigated the structural and functional characteristics of aortic wall degeneration in adult fibulin-4 deficient mice and the potential t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d09476d01b2b1c353d356b481ce8ce
https://pubmed.ncbi.nlm.nih.gov/21858106