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Autor:
Yanmin Chen, Stephen H. Eisennagel, Cesar Tio, Norman Huebert, Natashia Kagan, Deping Cheng, Bruce E. Tomczuk, Roger F. Bone, Malini Dasgupta
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:127-138
The pharmacokinetics of TDP4815 was evaluated in rats, rabbits, dogs and monkeys. After intravenous administration, TDP4815 achieved CO of 3255 ng/ml in rats at 5 mg/kg, 9066 ng/ml in rabbits and 7858 ng/ml in monkeys at 6 mg/kg, and 4457 ng/ml in do