Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Natasha de Alwis"'
Autor:
Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Sally Beard, Danielle A. Debruin, Alan Hayes, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality. Tocolytics are drugs used in cases of imminent preterm birth to inhibit uterine contractions. Nifedipine is a calcium channel blocking agent used to delay t
Externí odkaz:
https://doaj.org/article/ecae7aa9492148a588dc9ec772536a2e
Autor:
Bianca R. Fato, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Natasha de Alwis, Natalie J. Hannan
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2660 (2023)
Gestational diabetes mellitus (GDM) is a condition of pregnancy defined by new-onset hyperglycemia. GDM is associated with impaired maternal endothelial and vascular reactivity. Endothelin-1 (ET-1) is a potent vasoconstrictor that contributes to endo
Externí odkaz:
https://doaj.org/article/c4d4ec67fad0462a9d66aeeffb7c39f9
Autor:
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) transcripts are elevated in the circulation of individuals whose pregnancies are complicated by preterm fetal growth restriction (FGR). In this paper, we show that the cases with preeclam
Externí odkaz:
https://doaj.org/article/fd7a986eec1140abaec2740950069538
Autor:
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Lisa Hui, Stephen Tong, Natalie J. Hannan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Previously, we identified increased maternal circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction (FGR). Here, we assessed whether circulating DAAM2 mRNA could detect FGR, and whether the DAAM2 gene, known to
Externí odkaz:
https://doaj.org/article/651f19d9ebf742ba844ba2da24a85f7f
Autor:
Natalie K. Binder, Sally Beard, Natasha de Alwis, Bianca R. Fato, Tuong-Vi Nguyen, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6182 (2023)
Preeclampsia is associated with an increased lifelong risk of cardiovascular disease (CVD). It is not clear whether this is induced by persistent systemic organ and vascular damage following preeclampsia or due to a predisposition to both conditions
Externí odkaz:
https://doaj.org/article/2a303682986d41c091fe5fe2038086cb
Autor:
Elif Kadife, Alesia Harper, Natasha De Alwis, Keegan Chien, Natalie Hannan, Fiona C. Brownfoot
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 403 (2022)
Intrauterine growth restriction (IUGR), predominantly caused by placental insufficiency, affects partitioning of nutrients to the fetus. The system A sodium-coupled transporters (SNAT or SLC38), of types A1, A2, and A4, control non-essential amino ac
Externí odkaz:
https://doaj.org/article/a16f0255c5a34ca98fd8c9b815f378fd
Autor:
Bianca R. Fato, Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10852 (2022)
New-onset maternal hypertension is a hallmark of preeclampsia, driven by widespread endothelial dysfunction and systemic vasoconstriction. Here, we set out to create a new ex vivo model using preeclamptic serum to cause injury to the endothelium, mim
Externí odkaz:
https://doaj.org/article/a4329a6751cd45d88b1556996e14d849
Autor:
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1677 (2022)
Previously, we identified elevated transcripts for the gene Oleoyl-ACP Hydrolase (OLAH) in the maternal circulation of pregnancies complicated by preterm fetal growth restriction. As placental dysfunction is central to the pathogenesis of both fetal
Externí odkaz:
https://doaj.org/article/b2bec49f8b5240c9af935c324b4822c7
Autor:
Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu’uhevaha J. Kaitu’u-Lino, Kenji Onda, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9533 (2022)
Previously, we demonstrated that the proton pump inhibitor, esomeprazole magnesium hydrate (MH), could have potential as a repurposed treatment against preeclampsia, a serious obstetric condition. In this study we investigate the difference in the pr
Externí odkaz:
https://doaj.org/article/f7301bda208f48c6a4569e09d898b764
Autor:
Natasha de Alwis, Natalie K. Binder, Yeukai T. M. Mangwiro, Sally Beard, Natasha Pritchard, Elif Kadife, Bianca R. Fato, Emerson Keenan, Fiona C. Brownfoot, Tu’uhevaha J. Kaitu’u-Lino, Natalie J. Hannan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8185 (2022)
Preeclampsia is a devastating, multisystem disorder of pregnancy. It has no cure except delivery, which if premature can impart significant neonatal morbidity. Efforts to repurpose pregnancy-safe therapeutics for the treatment of preeclampsia have le
Externí odkaz:
https://doaj.org/article/1ead900accbc4f57b725f87980f8f68c