High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Autor: Maria A. Duque Correa, Simon P. Forman, Anneliese O. Speak, Dmitry S. Ushakov, Natasha A. Karp, Susana Caetano, Heather M. Wilson, George X. Song-Zhao, Matthew Edmans, Jacqueline K. White, Adam Laing, Namita Saran, Kevin J. Maloy, Justin Meskas, Sibyl Drissler, Emma L. Cambridge, Anna Chan, William R. Jacobs, Jua Iwasaki, Eleanor Cawthorne, Ramiro Ramirez-Solis, Alice Yue, Markus Pasztorek, Tanya L. Crockford, Richard K. Grencis, Amrutha Meeniga, Adrian Hayday, Cordelia Brandt, Albina Rahim, Terrence F. Meehan, Markus Lux, Leanne Kane, Belén Morón, George Notley, Johannes Abeler, Natasha Strevens, Keng I. Hng, Mark Griffiths, Carmen Ballesteros Reviriego, Katherine Harcourt, Fiona Powrie, Richard J. Cornall, David Melvin, Jeremy Mason, Jonathan Warren, David J. Adams, Simon Clare, Katherine R. Bull, Ryan R. Brinkman, Anna Lorenc, Gillian M. Griffiths, K. O. Babalola, Gordon Dougan, Brian Weinrick, Clare M. Lloyd, Lucie Abeler-Dörner, Philippa R. Barton, Agnieszka Przemska-Kosicka

Publikováno v: Forman, S, Grencis, R & et al. 2019, ' High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation ', Nature Immunology, vol. 21, pp. 86-100 . https://doi.org/10.1038/s41590-019-0549-0
Nat Immunol

By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 5

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