Describing the movement of molecules in reduced-dimension models

Autor: Natasha S. Savage

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)

Natasha Savage develops a general finite difference method for modeling 2D diffusion using a 1D reduced model. This method can be useful to improve the accuracy of many reduced-dimension models while retaining benefits of system simplification.

Externí odkaz: https://doaj.org/article/bb3eb29802104b7b9cb423283153eef3

Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit

Autor: Daniel J. Lew, Natasha S. Savage, Hsin Chen, Chun-Chen Kuo, Chi-Fang Wu, Trevin R. Zyla

Publikováno v: Current Biology

Summary Cell polarity is critical for the form and function of many cell types. During polarity establishment, cells define a cortical "front" that behaves differently from the rest of the cortex. The front accumulates high levels of the active form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a25dc41b7e895010b75059658df9161

Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds

Autor: H. Frederik Nijhout, Natasha S. Savage, Sam A. Johnson, Michael C. Reed, Trevin R. Zyla, Daniel J. Lew, Audrey S. Howell, Allison W. Wagner, Andrew B. Goryachev, Indrani Bose

Publikováno v: Cell
Howell, A S, Savage, N S, Johnson, S A, Bose, I, Wagner, A W, Zyla, T R, Nijhout, H F, Reed, M C, Goryachev, A B & Lew, D J 2009, ' Singularity in polarization : rewiring yeast cells to make two buds ', Cell, vol. 139, no. 4, pp. 731-743 . https://doi.org/10.1016/j.cell.2009.10.024

SUMMARY For budding yeast to ensure formation of only one bud, cells must polarize toward one, and only one, site. Polarity establishment involves the Rho family GTPase Cdc42, which concentrates at polarization sites via a positive feedback loop. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c1880eb2ae0712d3b2c3dcd2831add

Role of competition between polarity sites in establishing a unique front

Autor: Natasha S. Savage, Daniel J. Lew, Maria Minakova, Jian-geng Chiou, Denis Tsygankov, Benjamin Woods, Chi-Fang Wu, Trevin R. Zyla, Timothy C. Elston

Publikováno v: eLIFE
eLife
eLife, Vol 4 (2015)

Polarity establishment in many cells is thought to occur via positive feedback that reinforces even tiny asymmetries in polarity protein distribution. Cdc42 and related GTPases are activated and accumulate in a patch of the cortex that defines the fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f396f0e3f9d10e6e1477d19ebba9b4

Positional Signaling and Expression of ENHANCER OF TRY AND CPC1 Are Tuned to Increase Root Hair Density in Response to Phosphate Deficiency in Arabidopsis thaliana

Autor: Thomas J.W. Yang, Kai-Lan Lin, Wolfgang Schmidt, Chung Ying Chen, Nicholas A.M. Monk, Natasha S. Savage

Publikováno v: PLoS ONE
PloS one
PLoS ONE, Vol 8, Iss 10, p e75452 (2013)

Phosphate (Pi) deficiency induces a multitude of responses aimed at improving the acquisition of Pi, including an increased density of root hairs. To understand the mechanisms involved in Pi deficiency-induced alterations of the root hair phenotype i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843b6de3dc95aa7b78f4b8dbbf0b1d24
http://europepmc.org/articles/PMC3794009