Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Natasha P. Clayton"'
Autor:
Fabiola González-Herrera, Natasha S. Clayton, Daniela Guzmán-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalán, Renatto Anfossi, Helena Quintero-Pertuz, María Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raúl Vivar, Juan Diego Maya
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionChronic Chagasic cardiomyopathy (CCC), caused by the protozoan Trypanosoma cruzi, is the most severe manifestation of Chagas disease.CCC is characterized by cardiac inflammation and fibrosis caused by a persistent inflammatory response. F
Externí odkaz:
https://doaj.org/article/0be090d4f1914ee4ae40ee38765d5d98
Autor:
Natasha S. Clayton, Edward P. Carter, Abbie E. Fearon, James A. Heward, Lucía Rodríguez Fernández, Lina Boughetane, Edmund H. Wilkes, Pedro R. Cutillas, Richard P. Grose
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6228 (2023)
The downregulation of Pleckstrin Homology-Like Domain family A member 1 (PHLDA1) expression mediates resistance to targeted therapies in receptor tyrosine kinase-driven cancers. The restoration and maintenance of PHLDA1 levels in cancer cells thus co
Externí odkaz:
https://doaj.org/article/41d2bf807ac043e2b5610d93a6fe9f1d
Autor:
Natasha S. Clayton, Anne J. Ridley
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression. The adoption of a pro-migratory phenotype enables cancer cells to invade the s
Externí odkaz:
https://doaj.org/article/596ee592015e4110b68596d57ef188c4
Autor:
Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2469-2481 (2018)
Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenan
Externí odkaz:
https://doaj.org/article/7789669635aa4bc0b1737b37a1d0838a
Autor:
Natasha S. Clayton, Richard P. Grose
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Facto
Externí odkaz:
https://doaj.org/article/cb220b86b002407194266f6c6000a130
Autor:
Takeshi Izawa, Gregory S. Travlos, Ricardo A. Cortes, Natasha P. Clayton, Robert C. Sills, Arun R. Pandiri
Publikováno v:
Toxicologic Pathology. :019262332311711
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood. We investigated whether NAFLD can influence acetaminophen (APAP [N-acetyl-p-aminophenol])-induce
Autor:
Heather Jensen, Kyathanahalli S. Janardhan, Natasha P. Clayton, Gregory S. Travlos, Michelle C. Cora
Publikováno v:
Toxicologic pathology. 48(2)
Reticulum cell hyperplasia (RCH) was a term used for many years by the National Toxicology Program (NTP) to describe a certain non-neoplastic bone marrow lesion of rats. Retrospective microscopic evaluation of RCH lesions and immunohistochemistry ana
Autor:
Quashana D Brown, Natasha P. Clayton, Heather Jensen, Pamela Ovwigho, Darlene Dixon, Tonia Hermon, Barbara F Williams, Sreenivasa Ramaiahgari, Alanna Burwell
Publikováno v:
Toxicologic Pathology. 46:653-659
The use of three-dimensional (3-D) in vitro culture systems (spheroids, organoids) in biomolecular and drug discovery research has become increasingly popular. The popularity is due, in part, to a diminished reliance on animal bioassays and a desire
Autor:
Natasha P. Clayton, Jingli Liu, Lysandra Castro, Linda Yu, Darlene Dixon, Norris D. Flagler, Stephen S. Li, Pierre R. Bushel, Erica Scappini, Yitang Yan
Publikováno v:
The FASEB Journal. 34:1-1
Publikováno v:
Toxicologic pathology. 46(5)
Immunohistochemistry (IHC) is a valuable tool in pathology. This review provides a brief description of the technical aspects of IHC and a detailed discussion on the variables that affect the results, interpretation, and reproducibility of IHC result