Is Tissue Still the Issue? The Promise of Liquid Biopsy in Uveal Melanoma

Autor: Daniël P. de Bruyn, Aaron B. Beasley, Robert M. Verdijk, Natasha M. van Poppelen, Dion Paridaens, Ronald O. B. de Keizer, Nicole C. Naus, Elin S. Gray, Annelies de Klein, Erwin Brosens, Emine Kiliç

Publikováno v: Biomedicines, Vol 10, Iss 2, p 506 (2022)

Uveal melanoma (UM) is the second most frequent type of melanoma. Therapeutic options for UM favor minimally invasive techniques such as irradiation for vision preservation. As a consequence, no tumor material is obtained. Without available tissue, m

Externí odkaz: https://doaj.org/article/b4cdee1a79ac4277a4b12041240c314c

Is tissue still the issue?

Autor: Daniël P. de Bruyn, Aaron B. Beasley, Robert M. Verdijk, Natasha M. van Poppelen, Dion Paridaens, Ronald O. B. de Keizer, Nicole C. Naus, Elin S. Gray, Annelies de Klein, Erwin Brosens, Emine Kiliç

Publikováno v: Biomedicines, 10(2). MDPI

Uveal melanoma (UM) is the second most frequent type of melanoma. Therapeutic options for UM favor minimally invasive techniques such as irradiation for vision preservation. As a consequence, no tumor material is obtained. Without available tissue, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ea2bd45e9a7f7b9ac8315894ca144e
https://hdl.handle.net/1887/3563702

Molecular genetics of conjunctival melanoma and prognostic value of tert promoter mutation analysis

Autor: Frank J. Magielsen, Hendrikus J. Dubbink, Dion Paridaens, Annelies de Klein, Robert M. Verdijk, Bert Eussen, Tom Brands, Natasha M. van Poppelen, Nicole C. Naus, Erwin Brosens, Quincy C. C. van den Bosch, Emine Kilic, Jolanda Vaarwater, Jolique A van Ipenburg

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5784, p 5784 (2021)
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences, 22(11):5784. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11

The aim of this study was exploration of the genetic background of conjunctival melanoma (CM) and correlation with recurrent and metastatic disease. Twenty-eight CM from the Rotterdam Ocular Melanoma Study group were collected and DNA was isolated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc8936a7339d89f8fc1feaa819bae11
https://doi.org/10.3390/ijms22115784

Multicenter external validation of the Liverpool uveal melanoma prognosticator online

Autor: Armin R. Afshar, Martine J. Jager, Helen Kalirai, Emine Kilic, Azzam Taktak, Natasha M. van Poppelen, Nikolaos E. Bechrakis, Rudolf F. Guthoff, Heinrich Heimann, Antonio Eleuteri, Sarah E. Coupland, Bertil Damato, Norbert Bornfeld, Claudia H. D. Le Guin, Laura J. Bonnett, Gregorius P M Luyten, Alexander Tsygankov, Vinodh Kakkassery, Carlo Mosci, Matthew Traynor, Mehmet Dogrusöz, Rumana Hussain, Silvia Viaggi, Paolo Ligorio, Marina Marinkovic, Christopher J. Hill, S.V. Saakyan, Björn O Scheef, Kyra N Smit, Alda Cunha Rola, Annelies de Klein

Publikováno v: CANCERS
Cancers, Vol 12, Iss 2, p 477 (2020)
Cancers
Volume 12
Issue 2
Cancers, 12(2). MDPI
Cancers, 12. Multidisciplinary Digital Publishing Institute (MDPI)

Uveal melanoma (UM) is fatal in ~50% of patients as a result of disseminated disease. This study aims to externally validate the Liverpool Uveal Melanoma Prognosticator Online V3 (LUMPO3) to determine its reliability in predicting survival after trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06d3106e1b55869592804a0e4b2450a
https://hdl.handle.net/1887/3182910

Families with BAP1-Tumor Predisposition Syndrome in The Netherlands: Path to Identification and a Proposal for Genetic Screening Guidelines

Autor: Martine J. Jager, Jaco C. Bleeker, Maartje Nielsen, Nicole C. Naus, Marina Marinkovic, Liselotte P. van Hest, Marijke R. Wevers, Arjen R. Mensenkamp, Rolf H. Sijmons, Gregorius P M Luyten, Ans M.W. van den Ouweland, Barbara W. van Paassen, Nienke van der Stoep, Annemieke H. van der Hout, Thomas P. Potjer, Fonnet E. Bleeker, Cindy Chau, Natasha M. van Poppelen, Remco van Doorn, Marjolijn C.J. Jongmans

Publikováno v: Cancers, Vol 11, Iss 8, p 1114 (2019)
Cancers, 11(8)
Cancers, 11(8). Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 11(8):1114. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 11(8):1114. MDPI AG
Cancers
Volume 11
Issue 8
Cancers, 11, 8
Cancers, 11

Germline pathogenic variants in the BRCA1-associated protein-1 (BAP1) gene cause the BAP1-tumor predisposition syndrome (BAP1-TPDS, OMIM 614327). BAP1-TPDS is associated with an increased risk of developing uveal melanoma (UM), cutaneous melanoma (CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ec596992a74e93554b018562fcb4c
https://doi.org/10.3390/cancers11081114