Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Natasha M. Kablaoui"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:415-419
Oxytocin (OT) is a peptide hormone agonist of the oxytocin receptor (OTR) that has been proposed as a therapeutic to treat a number of social and emotional disorders in addition to its current clinical use to induce labor and treat postpartum bleedin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd5d1b4c2f9aa6960e34665377115d6
https://doi.org/10.1016/j.bmcl.2017.12.027
https://doi.org/10.1016/j.bmcl.2017.12.027
Autor:
Christopher Ryan Butler, Qingyi Yang, Michael Popiolek, Natasha M. Kablaoui, Lei Zhang, Sarah Grimwood, John T. Lazzaro, Rouba Kozak, Damien Webb, Rebecca E. O’Connor, Erik Alphie Lachapelle
Publikováno v:
ACS Med Chem Lett
[Image: see text] It has been hypothesized that selective muscarinic acetylcholine receptor (mAChR) M4 subtype activation could provide therapeutic benefits to a number of neurological disorders while minimizing unwanted cholinergic side effects obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b7038f52a14a71fc93cf610efea16b
https://pubmed.ncbi.nlm.nih.gov/31223452
https://pubmed.ncbi.nlm.nih.gov/31223452
Autor:
Bruce N. Rogers, Simone Sciabola, Kari R. Fonseca, Natasha M. Kablaoui, David Gray, Michelle Vanase-Frawley, Guoyun Bai, Gilles H. Goetz, Allen J. Duplantier
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3513-3520
Oxytocin (OT) is a peptide hormone agonist of the OT receptor (OTR) that plays an important role in social behaviors such as pair bonding, maternal bonding and trust. The pharmaceutical development of OT as an oral peptide therapeutic has been hinder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f865f06d5830b8a9ab10ad8278bb10
https://doi.org/10.1016/j.bmc.2016.05.062
https://doi.org/10.1016/j.bmc.2016.05.062
Autor:
Francioise Berlioz, Michael L. Vazquez, Natasha M. Kablaoui, Keith Hoffmaster, Douglas Demian, Richard A. Nugent, Snahel Patel, William M. Moore, Jay Shao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:907-911
A novel series of potent benzoxazole mPGES-1 inhibitors has been derived from a hit from a high throughput screen. Compound 37 displays mPGES-1 inhibition in an enzyme assay (0.018 μM) and PGE-2 inhibition in a cell-based assay (0.034 μM). It demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e95e60903160c5c5a4da578ef3fac6
https://doi.org/10.1016/j.bmcl.2012.10.040
https://doi.org/10.1016/j.bmcl.2012.10.040
Autor:
Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107
https://doi.org/10.1016/j.bmcl.2012.11.107
Autor:
Eric Feyfant, Natasha M. Kablaoui, Heather McInnes, Sarah M. Osgood, Michelle Vanase-Frawley, Ramin Darvari, Angela C. Doran, Kari R. Fonseca, Derek L. Buhl, Mark J. Majchrzak, Meera E. Modi
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Oxytocin (OT) modulates the expression of social and emotional behaviors and consequently has been proposed as a pharmacologic treatment of psychiatric diseases, including autism spectrum disorders and schizophrenia; however, endogenous OT has a shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b409ff47cab1e3155868ec1eb6f8f2
https://pubmed.ncbi.nlm.nih.gov/27217590
https://pubmed.ncbi.nlm.nih.gov/27217590
Autor:
Hu Liu, Cyrille Kuhn, Rahul Sharma, Natasha M. Kablaoui, Gordon Alton, Miret Juan, Brendan Connolly, Robert V. Stanton, Ping Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:849-852
S6K1 (p70 S6 kinase-1) is thought to play a critical role in the development of obesity and insulin resistance, thus making it an attractive target in developing medicines for the treatment of these disorders. We describe a novel thiophene urea class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88b0b52f1603ace77ae3414728ef2c
https://doi.org/10.1016/j.bmcl.2010.11.069
https://doi.org/10.1016/j.bmcl.2010.11.069
Autor:
Archana Chaudhry, Gary Bora, Robin Roof, Jiansu Zhang, Natasha M. Kablaoui, Maura E. Charlton, Bradley Snyder, Wendy M. Habeski, Cheryl Li, Snahel Patel, Hyunsuk Min, Brian M. Campbell, Douglas S. Johnson, Debra Hidayetoglu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5689-5693
The discovery of the CNS-penetrant and selective α 2C adrenergic receptor antagonist N -{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, 13 is described. Structure–activity studies demonstrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ae90347ee6fdc4b6bf4aff67fb2c11
https://doi.org/10.1016/j.bmcl.2008.08.055
https://doi.org/10.1016/j.bmcl.2008.08.055
Publikováno v:
Journal of the American Chemical Society. 121:5881-5898
A Pauson−Khand type conversion of enynes to bicyclic cyclopentenones employing the commercially available precatalyst titanocene dicarbonyl is described. This methodology shows excellent functional group tolerance for a group 4 metallocene-catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e735d587758b1d798ce3000ef969c92
https://doi.org/10.1021/ja990682u
https://doi.org/10.1021/ja990682u
Publikováno v:
Journal of the American Chemical Society. 119:4424-4431
A method for the transformation of o-allyl aryl ketones to γ-butyrolactones using a catalytic amount of Cp2Ti(PMe3)2 or Cp2Ti(CO)2 is described. This catalytic “hetero Pauson−Khand”-type process proceeds via the carbonylation of an oxatitanacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81318ebfdb9675bcc8051acb779ff601
https://doi.org/10.1021/ja970115b
https://doi.org/10.1021/ja970115b