Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Natasha M O'Brown"'
Publikováno v:
eLife, Vol 8 (2019)
As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellu
Externí odkaz:
https://doaj.org/article/17e50f7084c54216b67c97a57bfb0ff4
Publikováno v:
eLife, Vol 4 (2015)
Armor plate changes in sticklebacks are a classic example of repeated adaptive evolution. Previous studies identified ectodysplasin (EDA) gene as the major locus controlling recurrent plate loss in freshwater fish, though the causative DNA alteration
Externí odkaz:
https://doaj.org/article/66b4366fb786488fa966a9e314807405
Autor:
Ketaki A. Katdare, Andrew Kjar, Natasha M. O’Brown, Emma H. Neal, Alexander G. Sorets, Alena Shostak, Kate Mlouk, Hyosung Kim, Kensley B. Horner, Matthew S. Schrag, Sean G. Megason, Ethan S. Lippmann
Brain endothelial cells (BECs) play an important role in maintaining central nervous system (CNS) homeostasis through blood-brain barrier (BBB) functions. In addition to actively regulating material exchange between the circulation and CNS, BECs expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e16d7140479207dd29f74eaae4ecaea
https://doi.org/10.1101/2023.02.07.527394
https://doi.org/10.1101/2023.02.07.527394
Autor:
Sean G. Megason, Chenghua Gu, Natasha M O'Brown, Ursula Hartmann, Allon M. Klein, Nikit B. Patel
The blood-brain barrier (BBB) is a unique set of properties of the brain vasculature which severely restricts its permeability to proteins and small molecules. Classic chick-quail chimera studies showed that these properties are not intrinsic to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a894759a61b463c1a33e2726ab958403
https://doi.org/10.1101/2021.10.13.464312
https://doi.org/10.1101/2021.10.13.464312
Autor:
Chuan He, Jie Wang, Natasha M O'Brown, Ziyang Hao, Sean G. Megason, Hiroki Shibuya, Yang Shi, Tao Liu, Zach Klapholz O’Brown, Paul-Enguerrand Fady, Simon Yuan Wang, Konstantinos Boulias, Eric L. Greer
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
BMC Genomics
BMC Genomics
Background Directed DNA methylation on N6-adenine (6mA), N4-cytosine (4mC), and C5-cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of biological functions. These modifications are relatively abundant in bacteria, oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d626591a6e1b2edac35208a421a7897
http://link.springer.com/article/10.1186/s12864-019-5754-6
http://link.springer.com/article/10.1186/s12864-019-5754-6
Publikováno v:
Genes & Development. 32:466-478
The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c82e8dc8f245838f60429b2b2028c60
https://doi.org/10.1101/gad.309823.117
https://doi.org/10.1101/gad.309823.117
As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1bf39307a0ef8a167fa40d9227f9aa
Autor:
Zach K. O’Brown, Konstantinos Boulias, Jie Wang, Simon Yuan Wang, Natasha M. O’Brown, Ziyang Hao, Hiroki Shibuya, Paul-Enguerrand Fady, Yang Shi, Chuan He, Sean G. Megason, Tao Liu, Eric L. Greer
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Directed DNA methylation on N6-adenine (6mA), N4-cytosine (4mC), and C5-cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of biological functions. These modifications are relatively abundant in bac
Externí odkaz:
https://doaj.org/article/5f5c2596b8554fddb265cdf456fcd9f1