Výsledky vyhledávání - "Natasha Kondratieva"

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

Autor: Natasha Kondratieva, Anneke Funk, Shessy Torres, J. Leung, Roy A. Hall, Gorben P. Pijlman, Ann C. Palmenberg, Wen Jun Liu, Lieke van der Aa, Pei Yong Shi, Alexander A. Khromykh

Publikováno v: Cell Host & Microbe 4 (2008) 6
Cell Host & Microbe, 4(6), 579-591

SummaryViral noncoding RNAs have been shown to play an important role in virus-host interplay to facilitate virus replication. We report that members of the genus Flavivirus, a large group of medically important encephalitic RNA viruses, produce a un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0acabd3f986b17eaea8bfb851b12cf1

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Translation of the Flavivirus Kunjin NS3 Gene in cis but Not Its RNA Sequence or Secondary Structure Is Essential for Efficient RNA Packaging

Autor: Alexander A. Khromykh, Gorben P. Pijlman, Natasha Kondratieva

Publikováno v: Journal of Virology, 80(22), 11255-11264
Journal of Virology 80 (2006) 22

Our previous studies using trans -complementation analysis of Kunjin virus (KUN) full-length cDNA clones harboring in-frame deletions in the NS3 gene demonstrated the inability of these defective complemented RNAs to be packaged into virus particles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b920c79b0f16028f12f8e8e3cc08c3
https://doi.org/10.1128/jvi.01559-06

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Role of nonstructural protein NS2A in flavivirus assembly

Autor: Alexander A. Khromykh, J. Leung, Jennifer L. Hyde, Jason M. Mackenzie, Gorben P. Pijlman, Natasha Kondratieva

Publikováno v: Journal of Virology, 82(10), 4731-4741
Journal of Virology 82 (2008) 10

Flavivirus nonstructural (NS) proteins are involved in RNA replication and modulation of the host antiviral response; however, evidence is mounting that some NS proteins also have essential roles in virus assembly. Kunjin virus (KUN) NS2A is a small,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1271b21c668432ecdac0dc9a7c0eed
https://pubmed.ncbi.nlm.nih.gov/18337583

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Significance in replication of the terminal nucleotides of the flavivirus genome

Autor: Ann C. Palmenberg, Jean-Yves Sgro, Alexander A. Khromykh, Edwin G. Westaway, Natasha Kondratieva

Publikováno v: Journal of virology. 77(19)

Point mutations that resulted in a substitution of the conserved 3′-penultimate cytidine in genomic RNA or the RNA negative strand of the self-amplifying replicon of the Flavivirus Kunjin virus completely blocked in vivo replication. Similarly, sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01265833f7ab65a4856f846107321aaa
https://pubmed.ncbi.nlm.nih.gov/12970446

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Complementation Analysis of the Flavivirus Kunjin NS3 and NS5 Proteins Defines the Minimal Regions Essential for Formation of a Replication Complex and Shows a Requirement of NS3 in cis for Virus Assembly†

Autor: Alexander A. Khromykh, Natasha Kondratieva, Wen Jun Liu, Petra L. Sedlak

We have previously reported successful trans -complementation of defective Kunjin virus genomic RNAs with a range of large lethal deletions in the nonstructural genes NS1, NS3, and NS5 (A. A. Khromykh et al., J. Virol. 74: 3253-3263, 2000). In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea94b15f671693f2f8837954760229fb
https://europepmc.org/articles/PMC136631/

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