Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Natasha K. Crellin"'
Publikováno v:
Annals of the New York Academy of Sciences. 1217:60-76
Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of wh
Autor:
Eleonora Trotta, Paul H. Bessette, Stephanie L. Silveria, Lauren K. Ely, Kevin Jude, Charles R. Holst, Anthony Coyle, Christopher K. Garcia, Natasha K. Crellin, Isaac J. Rondon, Jeffrey A. Bluestone
Publikováno v:
The Journal of Immunology. 200:176.4-176.4
Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (Treg). However, this therapy has been limited by off-target complications due to pathogenic cell expansion. Recent efforts have been fo
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 207(2), 281-290. Rockefeller University Press
Journal of experimental medicine, 207(2), 281-290. Rockefeller University Press
Journal of Experimental Medicine, 207(2), 281-290. Rockefeller University Press
Journal of experimental medicine, 207(2), 281-290. Rockefeller University Press
Lymphoid tissue inducer (LTi) cells are required for lymph node formation during fetal development, and recent evidence implies a role in mucosal immunity in the adult. LTi cells share some phenotypic features of conventional natural killer (NK; cNK)
Publikováno v:
Blood. 109:2014-2022
Suppression by T regulatory cells (Treg cells) is a major mechanism by which the immune system controls responses to self and nonharmful foreign proteins. Although there are many different types of Treg cells, the best characterized are those that co
Autor:
Natasha K. Crellin, Rosa Garcia, Omeed Hadisfar, Megan K. Levings, Sarah E. Allan, Theodore S. Steiner
Publikováno v:
The Journal of Immunology. 175:8051-8059
Germline encoded pattern recognition receptors, such as TLRs, provide a critical link between the innate and adaptive immune systems. There is also evidence to suggest that pathogen-associated molecular patterns may have the capacity to modulate immu
Autor:
Rosa Bacchetta, Minyue Dai, Natasha K. Crellin, Laura Passerini, Sarah E. Allan, Paul C. Orban, Steven F. Ziegler, Maria Grazia Roncarolo, Megan K. Levings
Publikováno v:
Journal of Clinical Investigation. 115:3276-3284
Little is known about the molecules that control the development and function of CD4(+)CD25(+)Tregs. Recently, it was shown that the transcription factor FOXP3 is necessary and sufficient for the generation of CD4(+)CD25(+) Tregs in mice. We investig
Autor:
Wenjun Ouyang, Lauri Diehl, Naruhisa Ota, Patricia Valdez, Natasha K Crellin, Kit Wong, Yan Zheng
Publikováno v:
Nature immunology. 12(10)
Colonic patches (CLPs) and isolated lymphoid follicles (ILFs) are two main lymphoid structures in the colon. Lymphoid tissue-inducer cells (LTi cells) are indispensable for the development of ILFs. LTi cells also produce interleukin 17 (IL-17) and IL
Autor:
Jenny Mjösberg, Sara Trifari, Natasha K Crellin, Tom Cupedo, Cornelis M. van Drunen, Berber Piet, Wytske Fokkens, Hergen Spits, Charlotte P. Peters
Publikováno v:
Nature Immunology, 12(11), 1055-U56. Nature Publishing Group
Nature immunology, 12(11), 1055-1062. Nature Publishing Group
Nature immunology, 12(11), 1055-1062. Nature Publishing Group
Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor ROR gamma t, express CD127 (IL-7 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67db6d1b61fc23475d162ab23e5b32f3
https://pure.eur.nl/en/publications/be0a23ed-43a8-47b0-b8fa-b08e91ca0df1
https://pure.eur.nl/en/publications/be0a23ed-43a8-47b0-b8fa-b08e91ca0df1
Publikováno v:
Annual review of immunology. 29
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cyto
Publikováno v:
Annals of the New York Academy of Sciences. 1217
Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of wh