Výsledky vyhledávání - "Natasha K Crellin"

The IL-17 pathway as a major therapeutic target in autoimmune diseases

Autor: Natasha K Crellin, Fang Shen, Yan Hu, Wenjun Ouyang

Publikováno v: Annals of the New York Academy of Sciences. 1217:60-76

Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c55a39db0433095fa87d6b8e3a8781c
https://doi.org/10.1111/j.1749-6632.2010.05825.x

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Discovery of a novel human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism

Autor: Eleonora Trotta, Paul H. Bessette, Stephanie L. Silveria, Lauren K. Ely, Kevin Jude, Charles R. Holst, Anthony Coyle, Christopher K. Garcia, Natasha K. Crellin, Isaac J. Rondon, Jeffrey A. Bluestone

Publikováno v: The Journal of Immunology. 200:176.4-176.4

Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (Treg). However, this therapy has been limited by off-target complications due to pathogenic cell expansion. Recent efforts have been fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::757a779782326100d9019761b881b970
https://doi.org/10.4049/jimmunol.200.supp.176.4

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Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

Autor: Charles D. Kaplan, Natasha K Crellin, Tom Cupedo, Hergen Spits, Sara Trifari

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 207(2), 281-290. Rockefeller University Press
Journal of experimental medicine, 207(2), 281-290. Rockefeller University Press

Lymphoid tissue inducer (LTi) cells are required for lymph node formation during fetal development, and recent evidence implies a role in mucosal immunity in the adult. LTi cells share some phenotypic features of conventional natural killer (NK; cNK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0601a497eda5a9a143cd8f20814707
http://europepmc.org/articles/PMC2822607

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Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

Autor: Megan K. Levings, Natasha K. Crellin, Rosa Garcia

Publikováno v: Blood. 109:2014-2022

Suppression by T regulatory cells (Treg cells) is a major mechanism by which the immune system controls responses to self and nonharmful foreign proteins. Although there are many different types of Treg cells, the best characterized are those that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3891aebf4f11c30425f109072ff2d3c5
https://doi.org/10.1182/blood-2006-07-035279

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Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

Autor: Natasha K. Crellin, Rosa Garcia, Omeed Hadisfar, Megan K. Levings, Sarah E. Allan, Theodore S. Steiner

Publikováno v: The Journal of Immunology. 175:8051-8059

Germline encoded pattern recognition receptors, such as TLRs, provide a critical link between the innate and adaptive immune systems. There is also evidence to suggest that pathogen-associated molecular patterns may have the capacity to modulate immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aeee647278aed9ce833be201095240
https://doi.org/10.4049/jimmunol.175.12.8051

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

Autor: Rosa Bacchetta, Minyue Dai, Natasha K. Crellin, Laura Passerini, Sarah E. Allan, Paul C. Orban, Steven F. Ziegler, Maria Grazia Roncarolo, Megan K. Levings

Publikováno v: Journal of Clinical Investigation. 115:3276-3284

Little is known about the molecules that control the development and function of CD4(+)CD25(+)Tregs. Recently, it was shown that the transcription factor FOXP3 is necessary and sufficient for the generation of CD4(+)CD25(+) Tregs in mice. We investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139a8d9edeb826b020465a66e15f8e9b
https://doi.org/10.1172/jci24685

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IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Autor: Wenjun Ouyang, Lauri Diehl, Naruhisa Ota, Patricia Valdez, Natasha K Crellin, Kit Wong, Yan Zheng

Publikováno v: Nature immunology. 12(10)

Colonic patches (CLPs) and isolated lymphoid follicles (ILFs) are two main lymphoid structures in the colon. Lymphoid tissue-inducer cells (LTi cells) are indispensable for the development of ILFs. LTi cells also produce interleukin 17 (IL-17) and IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d1ccf2a3016f82a484bc829068166f
https://pubmed.ncbi.nlm.nih.gov/21874025

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Human IL-25-and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Autor: Jenny Mjösberg, Sara Trifari, Natasha K Crellin, Tom Cupedo, Cornelis M. van Drunen, Berber Piet, Wytske Fokkens, Hergen Spits, Charlotte P. Peters

Publikováno v: Nature Immunology, 12(11), 1055-U56. Nature Publishing Group
Nature immunology, 12(11), 1055-1062. Nature Publishing Group

Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22)- and IL-17-producing ILCs, which depend on the transcription factor ROR gamma t, express CD127 (IL-7 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67db6d1b61fc23475d162ab23e5b32f3
https://pure.eur.nl/en/publications/be0a23ed-43a8-47b0-b8fa-b08e91ca0df1

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Regulation and functions of the IL-10 family of cytokines in inflammation and disease

Autor: Sarah G. Hymowitz, Natasha K Crellin, Sascha Rutz, Patricia Valdez, Wenjun Ouyang

Publikováno v: Annual review of immunology. 29

The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eb5033ced152d04e4a02127d6287c7
https://pubmed.ncbi.nlm.nih.gov/21166540

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The IL-17 pathway as a major therapeutic target in autoimmune diseases

Autor: Yan, Hu, Fang, Shen, Natasha K, Crellin, Wenjun, Ouyang

Publikováno v: Annals of the New York Academy of Sciences. 1217

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a4e54cbcdc6064f339ba14d2fdcca19
https://pubmed.ncbi.nlm.nih.gov/21155836

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