Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Natasha J. Hill"'
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Akademický článek
Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress
Autor: Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with
Externí odkaz: https://doaj.org/article/0fb9c9d7a0d743c88c63bf86b8bef83e
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2
Fibronectin acts as a molecular switch to determine SPARC function in pancreatic cancer
Autor: Fatemia Mohamedi, Khalisha Malik, Hemant M. Kocher, Amanda Munasinghe, Natasha J. Hill, Lucy Jones, Stan Moaraf
Publikováno v: Cancer letters. 477
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all solid tumours and more effective therapy is urgently needed. The stroma is thought to play a critical role in tumour development and metastasis, and high stromal expression of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c1c2b12357425f805658a31fd06d26
https://pubmed.ncbi.nlm.nih.gov/32113990
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3
Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
Autor: Natasha J. Hill, Judith Allgrove, Declan P. Naughton, Hannah Moir, Mansour A. Alzharani, Simone Benedetti, Naser F. Al-Tannak, David J. Stensel, Alice E. Thackray, David G. Watson, Mehmet Tevfik Dorak, Owen Spendiff
Publikováno v: Metabolites, Vol 9, Iss 4, p 71 (2019)
Metabolites
Volume 9
Issue 4
South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed usin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab91e8978ef476f7cdc38def0f541caf
https://www.mdpi.com/2218-1989/9/4/71
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4
Vide-omics: A genomics-inspired paradigm for video analysis
Autor: Francisco Flórez-Revuelta, Maickael Dequidt, Ioannis Kazantzidis, Natasha J. Hill, Jean-Christophe Nebel
Publikováno v: RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Computer Vision And Image Understanding (1077-3142) (Academic Press Inc Elsevier Science), 2018-01, Vol. 166, P. 28-40
With the development of applications associated to ego-vision systems, smart-phones, and autonomous cars, automated analysis of videos generated by freely moving cameras has become a major challenge for the computer vision community. Current techniqu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9460e4da6949a79938211d420a491a
https://hdl.handle.net/10045/71834
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5
Novel Role for Matricellular Proteins in the Regulation of Islet β Cell Survival
Autor: Charlotte E. Edling, Aileen King, Fadel Lhaf, Hemant M. Kocher, Natasha J. Hill, Anthony J. Walker, Malin Flodström-Tullberg, David Mackintosh, Peter B. Jones, Rosemary McNeice, Claire L. Ryall, Katrina Viloria
Publikováno v: Journal of Biological Chemistry. 289:30614-30624
Understanding the mechanisms regulating islet growth and survival is critical for developing novel approaches to increasing or sustaining β cell mass in both type 1 and type 2 diabetes patients. Secreted protein acidic and rich in cysteine (SPARC) i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dd5fc6d1a5a5c4a3ea46648b799da7e
https://doi.org/10.1074/jbc.m114.573980
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6
A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth
Autor: Sharan Asher, Natasha J. Hill, Roberto Bogyere, Katrina Viloria, Lucy Jones, Amanda Munasinghe
Publikováno v: Scientific Reports
SPARC is a matricellular protein that is involved in both pancreatic cancer and diabetes. It belongs to a wider family of proteins that share structural and functional similarities. Relatively little is known about this extended family, but evidence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872bafe26a428361b5c5d49678cb1110
https://eprints.kingston.ac.uk/id/eprint/36358/3/Hill-N-36358-VoR.pdf
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7
Embracing the complexity of matricellular proteins: the functional and clinical significance of splice variation
Autor: Natasha J. Hill, Katrina Viloria
Publikováno v: Biomolecular Concepts, Vol 7, Iss 2, Pp 117-132 (2016)
Matricellular proteins influence wide-ranging fundamental cellular processes including cell adhesion, migration, growth and differentiation. They achieve this both through interactions with cell surface receptors and regulation of the matrix environm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9396c5254005189ece4d781507871419
https://pubmed.ncbi.nlm.nih.gov/27135623
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8
Does group assessment impact BME attainment?
Autor: James Denholm-Price, Owuraku Nimoh, Nigel Page, Natasha J. Hill, Luis Tojal Dourado, Nigel Atkins
Publikováno v: New Directions in the Teaching of Physics
Assessment of student learning is fundamental in Higher Education (HE) reflecting academic standards and impacting on student satisfaction, position in league tables and graduate employment. Nonetheless, there is a BME (Black and Minority Ethnic) att
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771c74dfbd38e5e3e40f2a74daabd28d
https://eprints.kingston.ac.uk/id/eprint/36768/1/Hill-N-36768-VoR.pdf
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9
Creating a 3D matricellular environment to promote islet expansion for diabetes therapy – the role of SPARC family proteins
Autor: Peter B. Jones, Katrina Viloria, Lucy Jones, Claire L. Ryall, Natasha J. Hill, Fadel Lhaf, Sharan Asher, Aileen King, Hemant M. Kocher, Amanda Dandagama
Publikováno v: The FASEB Journal. 29
Loss of the extracellular matrix following enzyme harvest of islets for transplantation renders them susceptible to a new environment, and is hypothesized to contribute to decreased graft function ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68d51b11f5343e0625400fe8cb88ac72
https://doi.org/10.1096/fasebj.29.1_supplement.719.16
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10
Pressurized water reactor in-core nuclear fuel management by tabu search
Autor: Geoffrey T. Parks, Natasha J. Hill
Optimization of the arrangement of fuel assemblies and burnable poisons when reloading pressurized water reactors has, in the past, been performed with many different algorithms in an attempt to make reactors more economic and fuel efficient. The use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e65b698869564d4d33e73b5a05e6e19
https://www.repository.cam.ac.uk/handle/1810/245632
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