Výsledky vyhledávání - "Natasha Freed"

Postoperative Patellar Height After Undergoing Total Knee Arthroplasty: Mechanical Axis Versus Kinematic Axis

Autor: Seleem Elkadi, Emily Krisanda, Brian J Panish, Stiles Donaldson, Eliana Schaefer, Malaak Hamzeh, John Bovill, Natasha Freed, Zachariah Elkordy, Seif El Masry, Gina Cach, Evan Jacquez, Evan Argintar

Publikováno v: Cureus. 14(4)

Introduction When performing total knee arthroplasty (TKA), surgeons may use either the mechanical alignment (MA) or the kinematic alignment (KA) to guide implant placement and joint balancing. By measuring preoperative and postoperative patellar hei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6f26c1e6d5150121a0c4d077f3c68a
https://pubmed.ncbi.nlm.nih.gov/35607561

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GTP-Dependent K-Ras Dimerization

Autor: Serena Muratcioglu, Ozlem Keskin, Hyunbum Jang, Lyuba Khavrutskii, Vadim Gaponenko, Karen Stefanisko, Benjamin C. Freed, Sergey G. Tarasov, R. Natasha Freed, Tanmay S. Chavan, Attila Gursoy, Ruth Nussinov, Nadya I. Tarasova, Marzena A. Dyba

Publikováno v: Structure. 23:1325-1335

SummaryRas proteins recruit and activate effectors, including Raf, that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, activation of Raf requires its dimerization. It has been suspected that dimeric Ras may promote dimeriza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a42ce37d5b9e452963296f31a5357f
https://doi.org/10.1016/j.str.2015.04.019

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Abstract 4850: Combination of effector mimicking with in silico fragment screens is an effective approach for the development of Ras inhibitors

Autor: R. Natasha Freed, Lyuba Khavrutskii, Colin Fields, Marc C. Nicklaus, Nadya I. Tarasova, Yuri Pevzner, Karen Stefanisko, Megan L. Peach

Publikováno v: Cancer Research. 76:4850-4850

Targeting Ras proteins directly has proven to be exceptionally challenging because they lack deep pockets on the surface that can provide for effective interactions with small molecules. Several shallow pockets have been identified on Ras surface. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a153b95f3dc4390db873b241c5c8ee1
https://doi.org/10.1158/1538-7445.am2016-4850

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