Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Natasha Fillmore"'
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
While fatty acid metabolism is altered under physiological conditions, alterations can also be maladaptive in diseases such as diabetes and heart failure. Peroxisome Proliferator Activated Receptor α (PPARα) is a transcription factor that regulates
Externí odkaz:
https://doaj.org/article/02859b4478474a58939d88c303dd4a31
Autor:
Wei Wang, MD, PhD, Liyan Zhang, PhD, Pavan K. Battiprolu, PhD, Arata Fukushima, MD, PhD, Khanh Nguyen, BS, Kenneth Milner, BS, Abhishek Gupta, PhD, Tariq Altamimi, PhD, Nikole Byrne, BS, Jun Mori, MD, PhD, Osama Abo Alrob, PhD, Cory Wagg, Natasha Fillmore, PhD, Shao-hua Wang, MD, PhD, Dongming M. Liu, BS, Angela Fu, BS, Jenny Yinglin Lu, BS, Mary Chaves, MS, Alykhan Motani, PhD, John R. Ussher, PhD, Jeff D. Reagan, PhD, Jason R.B. Dyck, PhD, Gary D. Lopaschuk, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
Summary: Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable ap
Externí odkaz:
https://doaj.org/article/79de453a1dda4adb8a04a801a0ccb1d3
Autor:
Junhui Sun, Weidong Hao, Natasha Fillmore, Hanley Ma, Danielle Springer, Zu‐Xi Yu, Agnieszka Sadowska, Andrew Garcia, Ruoyan Chen, Vanessa Muniz‐Medina, Kim Rosenthal, Jia Lin, Denison Kuruvilla, Jane Osbourn, Sotirios K. Karathanasis, Jill Walker, Elizabeth Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 24 (2019)
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin‐2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiog
Externí odkaz:
https://doaj.org/article/c5f74268cf9e4cc6a8104908bee069d8
Autor:
Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck, Gary D. Lopaschuk
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-12 (2018)
Abstract Background Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve.
Externí odkaz:
https://doaj.org/article/7a806544976a417fa449919a6d1449fa
Autor:
Josephine Harrington, Natasha Fillmore, Shouguo Gao, Yanqin Yang, Xue Zhang, Poching Liu, Andrea Stoehr, Ye Chen, Danielle Springer, Jun Zhu, Xujing Wang, Elizabeth Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundHeart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. Methods and ResultsThis study used a systems biology ap
Externí odkaz:
https://doaj.org/article/6d1f78a1b6c547c9888345f132b16a08
Autor:
Iman A Mohamed, Alain-Pierre Gadeau, Larry Fliegel, Gary Lopaschuk, Mohamed Mlih, Nabeel Abdulrahman, Natasha Fillmore, Fatima Mraiche
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123318 (2015)
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin (OPN) expression in mod
Externí odkaz:
https://doaj.org/article/ff6a49340365414ebd1606dcacf21e2a
Autor:
Natasha Fillmore, Alda Huqi, Jagdip S Jaswal, Jun Mori, Roxane Paulin, Alois Haromy, Arzu Onay-Besikci, Lavinia Ionescu, Bernard Thébaud, Evangelos Michelakis, Gary D Lopaschuk
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120257 (2015)
Successful stem cell therapy requires the optimal proliferation, engraftment, and differentiation of stem cells into the desired cell lineage of tissues. However, stem cell therapy clinical trials to date have had limited success, suggesting that a b
Externí odkaz:
https://doaj.org/article/43eb18d4498d43a1ac10fdbbd2c9fb57
Autor:
John R Ussher, Clifford D L Folmes, Wendy Keung, Natasha Fillmore, Jagdip S Jaswal, Virgilio J Cadete, Donna L Beker, Victoria H Lam, Liyan Zhang, Gary D Lopaschuk
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37703 (2012)
OBJECTIVE: Diet-induced obesity (DIO) leads to an accumulation of intra-myocardial lipid metabolites implicated in causing cardiac insulin resistance and contractile dysfunction. One such metabolite is ceramide, and our aim was to determine the effec
Externí odkaz:
https://doaj.org/article/eb5a06fe1d3c43e38320d5c0fab98aec
Publikováno v:
Physiology. 38
A dysregulated lipid metabolism contributes to the pathological development of a wide array of diseases including Type 2 Diabetes and associated cardiovascular diseases. One main regulator of cardiac lipid metabolism is the transcription factor Perox
Publikováno v:
PloS one. 17(3)
While fatty acid metabolism is altered under physiological conditions, alterations can also be maladaptive in diseases such as diabetes and heart failure. Peroxisome Proliferator Activated Receptor α (PPARα) is a transcription factor that regulates