Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Natasha Fernandez"'
Autor:
Jin-mo Gu, Sandra I. Grijalva, Natasha Fernandez, Elizabeth Kim, D. Brian Foster, Hee Cheol Cho
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 9, Pp 1-12 (2019)
Heart health: understanding pacemaker cells The heart’s pacemaker cells contain mitochondria that are smaller than average and require less energy than other heart cells, properties that help make them naturally resilient to stress. Cardiac pacemak
Externí odkaz:
https://doaj.org/article/41ab80b3ac45403e87c4103db9c1529c
Autor:
Sandra I. Grijalva, Jin‐mo Gu, Jun Li, Natasha Fernandez, Jinqi Fan, Jung Hoon Sung, Seung Yup Lee, Conner Herndon, Erin M. Buckley, Sung‐Jin Park, Flavio H. Fenton, Hee Cheol Cho
Publikováno v:
Advanced Science, Vol 6, Iss 22, Pp n/a-n/a (2019)
Abstract Every heartbeat originates from a tiny tissue in the heart called the sinoatrial node (SAN). The SAN harbors only ≈10 000 cardiac pacemaker cells, initiating an electrical impulse that captures the entire heart, consisting of billions of c
Externí odkaz:
https://doaj.org/article/087002c9464344d5ae7d42d4f4dc2991
Autor:
Sandra I. Grijalva, Doohwan Jung, Hua Wang, Adam Wang, Hee Cheol Cho, Natasha Fernandez, Jong Seok Park, Gregory V. Junek, Sagar R. Kumashi, Sensen Li
Publikováno v:
IEEE Journal of Solid-State Circuits. 56:2438-2451
This article presents a fully integrated multi-modal CMOS cellular sensor/stimulator array chip with 21 952 pixels and 1568-pixel concurrent readouts, while each array pixel can be independently reconfigured to support three sensing and one stimulati
Autor:
Jinqi Fan, Nam Kyun Kim, Natasha Fernandez, Tae Yun Kim, Jun Li, David Wolfson, Hee Cheol Cho
Implantable cardiac pacemaker devices are generally effective for patients with symptomatic bradyarrhythmia. However, device-dependent cardiac pacing is far from ideal and often inadequate, particularly for pediatric patients who need to go through i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58e1a2ce9fc803bb078b96000febbe8
https://doi.org/10.1101/2022.06.02.493572
https://doi.org/10.1101/2022.06.02.493572
Autor:
Sk Aysha Rashid, Aaron T. Blanchard, J. Dale Combs, Natasha Fernandez, Yixiao Dong, Hee Cheol Cho, Khalid Salaita
Publikováno v:
ACS nano. 16(4)
Cardiac muscle cells (CMCs) are the unit cells that comprise the heart. CMCs go through different stages of differentiation and maturation pathways to fully mature into beating cells. These cells can sense and respond to mechanical cues through recep
Autor:
Hee Cheol Cho, Natasha Fernandez, Jin mo Gu, Elizabeth H. Kim, D. Brian Foster, Sandra I. Grijalva
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 51, Iss 9, Pp 1-12 (2019)
Experimental and Molecular Medicine, Vol 51, Iss 9, Pp 1-12 (2019)
Cardiac pacemaker cells of the sinoatrial node initiate each and every heartbeat. Compared with our understanding of the constituents of their electrical excitation, little is known about the metabolic underpinnings that drive the automaticity of pac
Autor:
Angel Xiao, Philip J. Santangelo, Jinqi Fan, Ki Hong Lee, David Wolfson, Nam Kyun Kim, Hee Cho, Jared Beyersdorf, Jonathan J. Langberg, Natasha Fernandez
Publikováno v:
Circulation. 142
Introduction: Cardiac pacing can be created by myocardial delivery of TBX18. However, evidence for overt fibrosis at the injection site and the use of viral vectors impede clinical translation of this concept. We hypothesized that non-viral gene tran
Autor:
Jonathan J. Langberg, Natasha Fernandez, Jared Beyersdorf, Ki Hong Lee, Philip J. Santangelo, Nam Kyun Kim, Hee Cho, Minji Shin
Publikováno v:
Circulation. 142
Introduction: The efficacy and specificity of myocardial gene transfer depends on retention of the injectate at the site of gene delivery. However, no direct method exists to confirm myocardial retention of a biologic delivered via an intracardiac tr
Publikováno v:
Circulation. 142
Introduction: Transcription factor Tbx18 can reprogram chamber cardiomyocytes to induced pacemaker cells (iPMs). Transcriptomic analysis of Tbx18-iPMs identified Tgfβ pathway as a prominent signaling cascade in this transition. The activity of Tgfβ
Publikováno v:
Circulation. 142
Background: We have previously demonstrated that TBX18 suffices to reprogram postnatal ventricular cardiomyocytes to induced pacemaker cells (TBX18-iPMs). However, the nascent automaticity appeared to wane over time, characterized by loss of syncytia