Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Natasha E. Zachara"'
Autor:
Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1510-1529 (2022)
Background & Aims: The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc trans
Externí odkaz:
https://doaj.org/article/ea3c4596c6654707b658a0f0be83e403
Publikováno v:
Cells, Vol 11, Iss 21, p 3509 (2022)
The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational modification of mammalian proteins. O-GlcNAc is cycled on and off over 5000 prot
Externí odkaz:
https://doaj.org/article/444129a4b44d486d8ec43f61ddf7b39d
Autor:
Rebecca A. Sager, Mark R. Woodford, Sarah J. Backe, Alan M. Makedon, Alexander J. Baker-Williams, Bryanna T. DiGregorio, David R. Loiselle, Timothy A. Haystead, Natasha E. Zachara, Chrisostomos Prodromou, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1344-1356.e5 (2019)
Summary: The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this pr
Externí odkaz:
https://doaj.org/article/de66c6bb8ecb4bfabba4d27f34f19f26
Autor:
Dakota R. Robarts, Manasi Kotulkar, Diego Paine-Cabrera, Kaitlyn K. Venneman, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Publikováno v:
bioRxiv
Background & AimsO-GlcNAcylation is a post-translational modification catalyzed by the enzyme O-GlcNAc transferase (OGT), which transfers a single N-acetylglucosamine sugar from UDP-GlcNAc to the protein on serine and threonine residues on proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb38b02c1e8d5f7edc4c75180901618
https://doi.org/10.1101/2023.02.16.528884
https://doi.org/10.1101/2023.02.16.528884
Autor:
Bhargavi Narayanan, Natasha E. Zachara
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14d15d96ca2954621a658885b58a2541
https://doi.org/10.1016/b978-0-12-821618-7.00015-8
https://doi.org/10.1016/b978-0-12-821618-7.00015-8
Autor:
Partha S. Banerjee, Oscar E. Reyes Gaido, C. Conover Talbot, Neha Abrol, Elizabeth D. Luczak, Gerald W. Hart, Liliana Florea, Jonathan M. Granger, Natasha E. Zachara, Qinchuan Wang, Olurotimi O. Mesubi, An-Chi Wei, Mark E. Anderson, Priya Umapathi, Yuejin Wu
Publikováno v:
Circulation. 143:1687-1703
Background: Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes. O -GlcNAcylation (the attachment of O -linked β-N-acetylglucosamine [ O -GlcNAc] moieties to cytopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5beb658329f07b8817e2d39b33c5100d
https://doi.org/10.1161/circulationaha.120.051911
https://doi.org/10.1161/circulationaha.120.051911
Autor:
Kyriakos N. Papanicolaou, Jessica Jung, Deepthi Ashok, Wenxi Zhang, Amir Modaressanavi, Eddie Avila, D. Brian Foster, Natasha E. Zachara, Brian O'Rourke
Publikováno v:
Journal of Biological Chemistry. 299:102907
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f8ee9892c90de142e9437a5fc09627
https://doi.org/10.1016/j.jbc.2023.102907
https://doi.org/10.1016/j.jbc.2023.102907
Autor:
S. A. Whelan, M. Kotulkar, Chad Slawson, N. Lee, Hartmut Jaeschke, W. S. Parkes, S. Abernathy, D. S. Umbaugh, D. R. Robarts, Sumedha Gunewardena, S. R. McGreal, Natasha E. Zachara, John A. Hanover, Udayan Apte
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 13(5)
The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here we report that O-GlcNAcylation, an intracellular post-translational modification (PTM) regulated by two enzymes, O-GlcNAc transferase (OGT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908c65b74b3edbbdbc4af1f7c489b005
https://pubmed.ncbi.nlm.nih.gov/35093590
https://pubmed.ncbi.nlm.nih.gov/35093590
Autor:
Brian O'Rourke, D B Foster, Natasha E. Zachara, Deepthi Ashok, Agnes Sidor, Kyriakos N. Papanicolaou
Publikováno v:
Circulation Research. 129
The mitogen activated protein kinase (MAPK) p38 is important in cardiac hypertrophic responses and p38 inhibition has been tested as a potential therapeutic approach to heart failure. p38 is tightly regulated by upstream kinases and phosphatases. Whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cce18ca510f95b102f8e25664e11201
https://doi.org/10.1161/res.129.suppl_1.p379
https://doi.org/10.1161/res.129.suppl_1.p379
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c6778a1f3ccc785945e32e3cd9f2e7
https://doi.org/10.1096/fasebj.2021.35.s1.03700
https://doi.org/10.1096/fasebj.2021.35.s1.03700