Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Natasha Bohorova"'
Autor:
Alexandra Castilho, Natasha Bohorova, Josephine Grass, Ognian Bohorov, Larry Zeitlin, Kevin Whaley, Friedrich Altmann, Herta Steinkellner
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26040 (2011)
BackgroundFc-glycosylation of monoclonal antibodies (mAbs) has profound implications on the Fc-mediated effector functions. Alteration of this glycosylation may affect the efficiency of an antibody. However, difficulties in the production of mAbs wit
Externí odkaz:
https://doaj.org/article/c6fd415b0f934f4bb541f430c2038645
Autor:
Ramon A. Ortiz, Natasha Bohorova, Anna Z. Wec, Darryl Sampey, Kartik Chandran, Nicole M. Josleyn, Stephen J. Streatfield, Jeffery W. Froude, Ognian Bohorov, Samantha E. Zak, Zachary A. Bornholdt, Russell R. Bakken, R. Mark Jones, Andrew S. Herbert, Brian J. Green, Larry Zeitlin, Ana I. Kuehne, Do Han Kim, Spencer W. Stonier, Kevin J. Whaley, Danielle E. Dorosky, Michael H. Pauly, John M. Dye, Jesus Velasco, Vidadi Yusibov, Konstantin Musiychuk
Publikováno v:
Proc Natl Acad Sci U S A
Antibody-based therapies are a promising treatment option for managing ebolavirus infections. Several Ebola virus (EBOV)-specific and, more recently, pan-ebolavirus antibody cocktails have been described. Here, we report the development and assessmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bf42afc446d92805ad31e97b88321f
https://doi.org/10.1073/pnas.1914985117
https://doi.org/10.1073/pnas.1914985117
Autor:
Crystal L. Moyer, Rebekah M. James, John M. Dye, Ariel S. Wirchnianski, Xiangguo Qiu, Natasha Bohorova, Robert H. Bortz, Simon J. Anthony, Laura M. Walker, Guodong Liu, Zachary A. Bornholdt, Rohit K. Jangra, Zirui Zhang, Bronwyn M. Gunn, Wenjun Zhu, Eileen C. Goodwin, Tracey Goldstein, Michael H. Pauly, Andrew S. Herbert, Kevin J. Whaley, Larry Zeitlin, Anna Z. Wec, Do H. Kim, Ognian Bohorov, Galit Alter, Kartik Chandran, Shihua He, Jesus Velasco, Dafna M. Abelson, Russell R. Bakken
Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have entered clinical development are specific for a single member of the Ebolavirus ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b946571786c52a9fed01938861d404a7
https://europepmc.org/articles/PMC6396299/
https://europepmc.org/articles/PMC6396299/
Autor:
Erin K. Sully, Kevin J. Whaley, Michael H. Pauly, Ognian Bohorov, Larry Zeitlin, Do Jin Kim, Natasha Bohorova, Greta Van Slyke, Nicholas J. Mantis
Publikováno v:
Clinical and Vaccine Immunology. 23:795-799
PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c03cb9aabaab4aec35523f0ea346713
https://doi.org/10.1128/cvi.00088-16
https://doi.org/10.1128/cvi.00088-16
Autor:
Clemens Gruber, Herta Steinkellner, Karla A. Fenton, Sara Sahandi, M. Javad Aman, Natasha Bohorova, Delia Enria, Charles Goodman, Daniel J. Deer, Do Jin Kim, Xiaoguo Zhan, Jesus Velasco, Kevin J. Whaley, Anna N. Honko, Friedrich Altmann, Thomas W. Geisbert, Larry Zeitlin, Ana I. Kuehne, Joan B. Geisbert, Andrew Hiatt, Ognian Bohorov, Sven Enterlein, Michael H. Pauly
Publikováno v:
Proceedings of the National Academy of Sciences. 113:4458-4463
Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ba89f5d3309cfda40c1a373df75bf1
https://doi.org/10.1073/pnas.1600996113
https://doi.org/10.1073/pnas.1600996113
Autor:
Ognian Bohorov, Lisa E. Hensley, Christopher Bartos, Gene G. Olinger, Michael R. Holbrook, Ralph S. Baric, Jeffrey Solomon, Joshua C. Johnson, Ulas Bagci, Jiusong Sun, Nicholas Oberlander, Daniel J. Mollura, Peter B. Jahrling, Larry Zeitlin, Xianchun Tang, Charles Goodman, Wayne A. Marasco, Louis Huzella, Natasha Bohorova, Kevin J. Whaley, James Pettitt, Reed F. Johnson, Michael H. Paulty, Quan Zhu, Britini L. Ork, Do H. Kim, Jing Qin, Lauren Keith, Jesus Velasco
Publikováno v:
Virology
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438d8f7ddf92f132d35a3f1789fcd48d
Autor:
Yinghui Rong, Lara A. Doyle-Meyers, Dylan J. Ehrbar, Michael H. Pauly, Ognian Bohorov, Chad J. Roy, Peter J. Didier, Nicholas J. Mantis, Ellen S. Vitetta, Fernando J Torres-Velez, Do Jin Kim, Kevin J. Whaley, Larry Zeitlin, Natasha Bohorova
Publikováno v:
JCI insight. 4(1)
Ricin toxin (RT) ranks at the top of the list of bioweapons of concern to civilian and military personnel alike, due to its high potential for morbidity and mortality after inhalation. In nonhuman primates, aerosolized ricin triggers severe acute res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73be38c0dad7d4e6a572d262abea697c
https://pubmed.ncbi.nlm.nih.gov/30626745
https://pubmed.ncbi.nlm.nih.gov/30626745
Autor:
Fernando J Torres-Velez, Ognian Bohorov, Chad J. Roy, Kevin J. Whaley, Yinghui Rong, Peter J. Didier, Lara A. Doyle-Meyers, Do Jin Kim, Dylan J. Ehrbar, Michael H. Pauly, Nicholas J. Mantis, Larry Zeitlin, Natasha Bohorova, Ellen S. Vitetta
Ricin toxin ranks at the top of the list of potential bioweapons of concern to civilian and military personnel alike due to the high potential for morbidity and mortality after inhalation. In non-human primates, aerosolized ricin triggers a severe ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee13e34282188fd75f7a0fe6ae24d12
Autor:
Jesus Velasco, Robert W. Cross, Rebekah M. James, Galit Alter, Kartik Chandran, Niaz Rahim, Dafna M. Abelson, John M. Dye, Andrew S. Herbert, Kevin J. Whaley, Xiangguo Qiu, Michael H. Pauly, Shihua He, Do H. Kim, Logan Banadyga, Natasha Bohorova, Kevin Tierney, Viktoriya Borisevich, Anna Z. Wec, Eric Ailor, Laura M. Walker, Joan B. Geisbert, Eileen C. Goodwin, Chad E. Mire, Bronwyn M. Gunn, Wenjun Zhu, Ognian Bohorov, Thomas W. Geisbert, Zachary A. Bornholdt, William S. Shestowsky, Krystle N. Agans, Larry Zeitlin
All available experimental vaccines and immunotherapeutics1,2 against Ebola virus (EBOV), including rVSV-ZEBOV3 and ZMappTM4, lack activity against other ebolaviruses associated with human disease outbreaks. This year, two separate outbreaks of EBOV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c61c819d381e3e9deb68c869a4089e0
https://doi.org/10.1101/395533
https://doi.org/10.1101/395533
Autor:
Kara J. Levinson, Natasha Bohorova, Nicholas J. Mantis, Do H. Kim, Kevin J. Whaley, Michael H. Pauly, Samantha R. Giffen, Larry Zeitlin, Ognian Bohorov
Publikováno v:
Journal of Immunological Methods. 422:111-117
We have produced and characterized two chimeric human IgG1 monoclonal antibodies that bind different immunodominant epitopes on Vibrio cholerae lipopolysaccharide (LPS). MAb 2D6 IgG1 recognizes Ogawa O-polysaccharide antigen, while mAb ZAC-3 IgG1 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8737d862bd72e771b446256327cecbb
https://doi.org/10.1016/j.jim.2015.04.001
https://doi.org/10.1016/j.jim.2015.04.001