Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Natasha A. Trzaskalski"'
Autor:
Evgenia Fadzeyeva, Cassandra A.A. Locatelli, Natasha A. Trzaskalski, My-Anh Nguyen, Megan E. Capozzi, Branka Vulesevic, Nadya M. Morrow, Peyman Ghorbani, Antonio A. Hanson, Ilka Lorenzen-Schmidt, Mary-Anne Doyle, Richard Seymour, Elodie M. Varin, Morgan D. Fullerton, Jonathan E. Campbell, Erin E. Mulvihill
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106748- (2023)
Summary: Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the
Externí odkaz:
https://doaj.org/article/213537b074c74de6ba1a3b4427a6b586
Autor:
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not
Externí odkaz:
https://doaj.org/article/40cdcc7f6d5742ecbe16d60323de171c
Autor:
Nicholas D. LeBlond, Peyman Ghorbani, Conor O'Dwyer, Nia Ambursley, Julia R.C. Nunes, Tyler K.T. Smith, Natasha A. Trzaskalski, Erin E. Mulvihill, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1697-1706 (2020)
The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesis. Using LysM-Cre to dri
Externí odkaz:
https://doaj.org/article/f36517f379a741489a56e4fcfe0c1791
Publikováno v:
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 13 (2020)
Dipeptidyl peptidase-4 (DPP4) is a serine protease that rapidly inactivates the incretin peptides, glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptide to modulate postprandial islet hormone secretion and glycemia. Dipeptidyl pep
Externí odkaz:
https://doaj.org/article/cc3cb34db4cb42b091349b412005eec5
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O'Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. While dozens of preclinical models have been developed to recapitulate stages of MAFLD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddd5663855abf5b1478529ddeb4f6a0
https://doi.org/10.1152/ajpendo.00124.2023
https://doi.org/10.1152/ajpendo.00124.2023
Autor:
Nadya M. Morrow, Natasha A. Trzaskalski, Antonio A. Hanson, Evgenia Fadzeyeva, Dawn E. Telford, Sanjiv S. Chhoker, Brian G. Sutherland, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:127-144
Objective: Nobiletin is a dietary flavonoid that improves insulin resistance and atherosclerosis in mice with metabolic dysfunction. Dysregulation of intestinal lipoprotein metabolism contributes to atherogenesis. The objective of the study was to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8d86c65e0ba1455c85db28e5307b0b
https://doi.org/10.1161/atvbaha.121.316896
https://doi.org/10.1161/atvbaha.121.316896
Autor:
Melissa M. Dann, Sydney Q. Clark, Natasha A. Trzaskalski, Conner C. Earl, Luke E. Schepers, Serena M. Pulente, Ebonee N. Lennord, Karthik Annamalai, Joseph M. Gruber, Abigail D. Cox, Ilka Lorenzen-Schmidt, Richard Seymour, Kyoung-Han Kim, Craig J. Goergen, Erin E. Mulvihill
Publikováno v:
Am J Physiol Heart Circ Physiol
Ischemic heart disease is the leading cause of death in the United States, Canada, and worldwide. Severe disease is characterized by coronary artery occlusion, loss of blood flow to the myocardium, and necrosis of tissue, with subsequent remodeling o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b18d35e2f3d6ce7880b7d9cd1ad64f5
https://pubmed.ncbi.nlm.nih.gov/34995167
https://pubmed.ncbi.nlm.nih.gov/34995167
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O’Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
ObjectiveMetabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. Potential therapeutic targets have been identified and are currently being pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97799496696775ed8d54eaf274a706c2
https://doi.org/10.1101/2023.01.24.524609
https://doi.org/10.1101/2023.01.24.524609
Autor:
Natasha A, Trzaskalski, Branka, Vulesevic, My-Anh, Nguyen, Natasha, Jeraj, Evgenia, Fadzeyeva, Nadya M, Morrow, Cassandra Aa, Locatelli, Nicole, Travis, Antonio A, Hanson, Julia Rc, Nunes, Conor, O'Dwyer, Jelske N, Van der Veen, Ilka, Lorenzen-Schmidt, Rick, Seymour, Serena M, Pulente, Andrew C, Clément, Angela M, Crawley, René L, Jacobs, Mary-Anne, Doyle, Curtis L, Cooper, Kyoung-Han, Kim, Morgan D, Fullerton, Erin E, Mulvihill
Publikováno v:
JCI insight.
Elevated circulating dipeptidyl-peptidase 4 is a biomarker for liver disease, but its involvement in gluconeogenesis and in metabolic-associated fatty liver disease (MAFLD) progression remains unclear. Here we identified that DPP4 in hepatocytes but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43f57cba184f18df8540c9d4e25538c2
https://pubmed.ncbi.nlm.nih.gov/36472923
https://pubmed.ncbi.nlm.nih.gov/36472923
Autor:
Nadya Morrow, Natasha A Trzaskalski, Antonio A Hanson, Cassandra A Locatelli, Serena M Pulente, Erin E Mulvihill
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Introduction: The small intestine receives hormonal and neuronal stimuli to ensure sufficient nutrient absorption to fuel the body. Insulin resistance promotes aberrant dietary fat delivery into circulation, increasing the risk of cardiovascular dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2344a183cb94cdc3e8945e6e536584f2
https://doi.org/10.1161/atvb.42.suppl_1.531
https://doi.org/10.1161/atvb.42.suppl_1.531