Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Natasha A. Karp"'
Autor:
Tracy-Shi Zhang Fang, Yu Sun, Andrew C. Pearce, Simona Eleuteri, Mark Kemp, Christopher A. Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M. Márkus, Christopher J. Lelliott, Natasha A. Karp, David J. Adams, Stephen P. Jackson, Jin-Feng Zhao, Ian G. Ganley, Paul W. Thompson, Gabriel Balmus, David K. Simon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may dr
Externí odkaz:
https://doaj.org/article/231adfbea4cd447195e9caff8d44823d
Autor:
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
Publikováno v:
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-7 (2020)
Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of info
Externí odkaz:
https://doaj.org/article/ea37cc3bf4b84470b591684c9c09631e
Autor:
Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-relat
Externí odkaz:
https://doaj.org/article/b33496fa8a17473f945f0a89142ec415
Autor:
Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, International Mouse Phenotyping Consortium, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory se
Externí odkaz:
https://doaj.org/article/903b3cd9e9ab44c786e930b7a65ed71e
Autor:
Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R. Davies, Jonathan Cairns, Natasha A. Karp
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
The high attrition rate of preclinical agents entering oncology clinical trials has been associated with poor understanding of the heterogeneous patient response, arising from limitations in the preclinical pipeline with cancer models. Patient-derive
Externí odkaz:
https://doaj.org/article/fbe31529bc76498fa1d09b256d8e05d0
Autor:
Elizabeth Tuck, Jeanne Estabel, Anika Oellrich, Anna Karin Maguire, Hibret A. Adissu, Luke Souter, Emma Siragher, Charlotte Lillistone, Angela L. Green, Hannah Wardle-Jones, Damian M. Carragher, Natasha A. Karp, Damian Smedley, Niels C. Adams, Sanger Institute Mouse Genetics Project, James N. Bussell, David J. Adams, Ramiro Ramírez-Solis, Karen P. Steel, Antonella Galli, Jacqueline K. White
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 11, Pp 1467-1478 (2015)
Knowledge of the expression profile of a gene is a critical piece of information required to build an understanding of the normal and essential functions of that gene and any role it may play in the development or progression of disease. High-through
Externí odkaz:
https://doaj.org/article/daaf80acd0f34d59a38d89667e942261
Autor:
Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 5, Pp 515-524 (2014)
The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable
Externí odkaz:
https://doaj.org/article/a632df6494f3436791d1546d1ea369e7
Autor:
Vanessa Tabea von Kortzfleisch, Oliver Ambrée, Natasha A Karp, Neele Meyer, Janja Novak, Rupert Palme, Marianna Rosso, Chadi Touma, Hanno Würbel, Sylvia Kaiser, Norbert Sachser, S Helene Richter
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001564 (2022)
The credibility of scientific research has been seriously questioned by the widely claimed "reproducibility crisis". In light of this crisis, there is a growing awareness that the rigorous standardisation of experimental conditions may contribute to
Externí odkaz:
https://doaj.org/article/f1ab1606796343cfac2e7c9bd09659cf
Autor:
Manuel Spitschan, Nayantara Santhi, Amrita Ahluwalia, Dorothee Fischer, Lilian Hunt, Natasha A Karp, Francis Lévi, Inés Pineda-Torra, Parisa Vidafar, Rhiannon White
Publikováno v:
eLife, Vol 11 (2022)
Growing evidence shows that sex differences impact many facets of human biology. Here we review and discuss the impact of sex on human circadian and sleep physiology, and we uncover a data gap in the field investigating the non-visual effects of ligh
Externí odkaz:
https://doaj.org/article/f119125cadf64eb6bf223214de317f6f
Autor:
Darren A.E. Cross, Zack Cheng, Lars Farde, Paul D. Smith, James W.T. Yates, Richard A. Ward, M. Raymond V. Finlay, Natasha A. Karp, Albert D. Windhorst, Mohammad Mahdi Moein, Ana Vazquez-Romero, Evgeny Revunov, Jonas Malmquist, Mikhail Kondrashov, Ryosuke Arakawa, Akihiro Takano, Aaron Smith, Joanne Wilson, Annika Janefeldt, Lin Zhang, James Atkinson, Peter Barton, Gareth Maglennon, Don X. Nguyen, Minghui Zhao, Sally J. Adua, Katarina Varnäs, Richard Goodwin, Magnus Schou, Gail L. Wrigley, Yumei Yan, Nicole Strittmatter, Peter Johnström, Kan Chen, Nicola Colclough
Purpose:Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–brain barrier (BBB) permeability is considered desirable for increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e99bce52b9e8d79380691bf89afec19
https://doi.org/10.1158/1078-0432.c.6528456
https://doi.org/10.1158/1078-0432.c.6528456