Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Natasha, Spottiswoode"'
Autor:
Natasha Spottiswoode, Alexandra Tsitsiklis, Victoria T. Chu, Hoang Van Phan, Catherine DeVoe, Christina Love, Rajani Ghale, Joshua Bloomstein, Beth Shoshana Zha, Cole P. Maguire, Abigail Glascock, Aartik Sarma, Peter M. Mourani, Katrina L. Kalantar, Angela Detweiler, Norma Neff, Sidney C. Haller, COMET Consortium, Joseph L. DeRisi, David J. Erle, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Matthew F. Krummel, Michael A. Matthay, Prescott G. Woodruff, Carolyn S. Calfee, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Secondary bacterial pneumonia (2°BP) is associated with significant morbidity following respiratory viral infection, yet remains incompletely understood. In a prospective cohort of 112 critically ill adults intubated for COVID-19, we compar
Externí odkaz:
https://doaj.org/article/c54e44e92cce4848a4f22b7f58a64b95
Autor:
Natasha Spottiswoode, Julia C. Haston, Natasha W. Hanners, Katherine Gruenberg, Annie Kim, Joseph L. DeRisi, Michael R. Wilson
Publikováno v:
Therapeutic Advances in Infectious Disease, Vol 11 (2024)
Granulomatous amebic encephalitis, caused by the free-living amebae Balamuthia mandrillaris or Acanthamoeba species, is a rare and deadly infectious syndrome with a current mortality rate of >90%. Much work remains to define the optimal treatment for
Externí odkaz:
https://doaj.org/article/e3bbcb4ebc2b42028cd1776a5500b9df
Autor:
Natasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T. Laurie, Maham Zia, Camille Fouassier, Christine L. Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew Bollen, Charles Y. Chiu, Michael R. Wilson, Liza Valdivia, Joseph L. DeRisi
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 1, Pp 197-201 (2023)
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typ
Externí odkaz:
https://doaj.org/article/5da61a78676945518ef5302991f98480
Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure
Autor:
Rajani Ghale, Natasha Spottiswoode, Mark S. Anderson, Anthea Mitchell, Grace Wang, Carolyn S. Calfee, Joseph L. DeRisi, Charles R. Langelier
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-4 (2022)
Abstract Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto-Abs are unique to COVID-19, or
Externí odkaz:
https://doaj.org/article/9d29d6413f03472e84cfd897a7ffe3f2
Autor:
Natasha Spottiswoode, Samantha Hao, Estella Sanchez-Guerrero, Angela M. Detweiler, Honey Mekonen, Norma Neff, Henriette Macmillan, Brian S. Schwartz, Joanne Engel, Joseph L. DeRisi, Steven A. Miller, Charles R. Langelier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by the United States Centers for Disease Control and Prevention. Here, we used whole genome sequencing (WGS) to investigate recurrent P. aeruginosa bloodstream infect
Externí odkaz:
https://doaj.org/article/2828eeef9fac42af85ebf115d386a7b2
Autor:
Kaia E. Barth, Natasha Spottiswoode, Charlotte Hurabielle, Lakshmi Subbaraj, COMET Consortium, Carolyn S. Calfee, Michael A. Matthay, Sarah French, Andrew Connolly, Stephen M. Hewitt, Kevin M. Vannella, Christopher Barnett, Charles R. Langelier, Sarah Patterson
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ImportanceMultisystem inflammatory syndrome in adults (MIS-A) is a poorly understood complication of SARS-CoV-2 infection with significant morbidity and mortality.ObjectiveIdentify clinical, immunological, and histopathologic features of MIS-A to imp
Externí odkaz:
https://doaj.org/article/6545ff54e0cd48c0ac63dd25066a0f97
Autor:
Eran Mick, Alexandra Tsitsiklis, Natasha Spottiswoode, Saharai Caldera, Paula Hayakawa Serpa, Angela M. Detweiler, Norma Neff, Angela Oliveira Pisco, Lucy M. Li, Hanna Retallack, Kalani Ratnasiri, Kayla M. Williamson, Victoria Soesanto, Eric A. F. Simões, Christiana Smith, Lisa Abuogi, Amy Kistler, Brandie D. Wagner, Joseph L. DeRisi, Lilliam Ambroggio, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in
Externí odkaz:
https://doaj.org/article/c9e006ab7ba94c9dbbc5609925764a1e
Autor:
Aartik Sarma, Stephanie A. Christenson, Ashley Byrne, Eran Mick, Angela Oliveira Pisco, Catherine DeVoe, Thomas Deiss, Rajani Ghale, Beth Shoshana Zha, Alexandra Tsitsiklis, Alejandra Jauregui, Farzad Moazed, Angela M. Detweiler, Natasha Spottiswoode, Pratik Sinha, Norma Neff, Michelle Tan, Paula Hayakawa Serpa, Andrew Willmore, K. Mark Ansel, Jennifer G. Wilson, Aleksandra Leligdowicz, Emily R. Siegel, Marina Sirota, Joseph L. DeRisi, Michael A. Matthay, COMET Consortium, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Matthew F. Krummel, Prescott G. Woodruff, David J. Erle, Carolyn S. Calfee, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to
Externí odkaz:
https://doaj.org/article/5e15572a162f473290932a34e9eb1ffa
Autor:
Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri, Jennifer M. Babik, Gloria Castañeda, Joseph L. DeRisi, Angela M. Detweiler, Samantha L. Hao, Kirsten N. Kangelaris, G. Renuka Kumar, Lucy M. Li, Sabrina A. Mann, Norma Neff, Priya A. Prasad, Paula Hayakawa Serpa, Sachin J. Shah, Natasha Spottiswoode, Michelle Tan, Carolyn S. Calfee, Stephanie A. Christenson, Amy Kistler, Charles Langelier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors provide upper airway gene expression data from patients with COVID-19 and other viral and non-viral acute respiratory illnesses. They find attenuated activation of innate immune and pro-inflammatory pathways in COVID-19 as compared
Externí odkaz:
https://doaj.org/article/408b6cd697fa4ad18907bc9b834782d0
Autor:
Sachin J. Shah, Peter N. Barish, Priya A. Prasad, Amy Kistler, Norma Neff, Jack Kamm, Lucy M. Li, Charles Y. Chiu, Jennifer M. Babik, Margaret C. Fang, Yumiko Abe-Jones, Narges Alipanah, Francisco N. Alvarez, Olga Borisovna Botvinnik, Gloria Castaneda, Rand M. Dadasovich, Jennifer Davis, Xianding Deng, Joseph L. DeRisi, Angela M. Detweiler, Scot Federman, John Haliburton, Samantha Hao, Andrew D. Kerkhoff, G. Renuka Kumar, Katherine B. Malcolm, Sabrina A. Mann, Sandra Martinez, Rupa K. Mary, Eran Mick, Lusajo Mwakibete, Nader Najafi, Michael J. Peluso, Maira Phelps, Angela Oliveira Pisco, Kalani Ratnasiri, Luis A. Rubio, Anna Sellas, Kyla D. Sherwood, Jonathan Sheu, Natasha Spottiswoode, Michelle Tan, Guixia Yu, Kirsten Neudoerffer Kangelaris, Charles Langelier
Publikováno v:
EClinicalMedicine, Vol 27, Iss , Pp 100518- (2020)
Background: Most data on the clinical presentation, diagnostics, and outcomes of patients with COVID-19 have been presented as case series without comparison to patients with other acute respiratory illnesses. Methods: We examined emergency departmen
Externí odkaz:
https://doaj.org/article/2d343b2b38d34defb7023809f69ef7d7