Editorial: Ion channels and transporters in diabetes and metabolic diseases

Autor: Michael Puljung, Elizabeth Haythorne, Maria Rohm, Natascia Vedovato

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/ccd692a75aa0487dab92771af35baf81

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

Autor: Michael Puljung, Natascia Vedovato, Samuel Usher, Frances Ashcroft

Publikováno v: eLife, Vol 8 (2019)

The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). We used a novel approach involving labeling of intact channels in a native, membrane environment with a non-cano

Externí odkaz: https://doaj.org/article/7f916e61f8a14fc0a7f9a33162e35c07

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel

Autor: Tanadet Pipatpolkai, Samuel G. Usher, Natascia Vedovato, Frances M. Ashcroft, Phillip J. Stansfeld

Publikováno v: Pipatpolkai, T, Usher, S G, Vedovato, N, Ashcroft, F M & Stansfeld, P J 2022, ' The dynamic interplay of PIP 2 and ATP in the regulation of the K ATP channel ', The Journal of Physiology, vol. 600, no. 20, pp. 4503-4519 . https://doi.org/10.1113/JP283345

KEY POINTS: The KATP channel is activated by the binding of phosphoinositol-bisphosphate (PIP2 ) lipids and inactivated by the binding of adenosine triphosphate (ATP). K39 has the potential to bind to both PIP2 and ATP. A mutation to this residue (K3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f11a334096095b3567a7a9f7373d65
https://doi.org/10.1101/2021.05.06.442933

Role of the C‐terminus of SUR in the differential regulation of β‐cell and cardiac K ATP channels by MgADP and metabolism

Autor: Olof Rorsman, Peter Proks, Natascia Vedovato, Konstantin Hennis, Frances M. Ashcroft

Publikováno v: The Journal of Physiology. 596:6205-6217

Key points β-Cell KATP channels are partially open in the absence of metabolic substrates, whereas cardiac KATP channels are closed. Using cloned channels heterologously expressed in Xenopus oocytes we measured the effect of MgADP on the MgATP conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96908dd831507d4c7ee2e02eb3a0ee47
https://doi.org/10.1113/jp276708

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes

Autor: Frances M. Ashcroft, Tarig Babiker, Roisin Finn, Sarah E. Flanagan, Maggie Shepherd, Andrew T. Hattersley, Natascia Vedovato, Nicholas J. Thomas, Sian Ellard, Ali J. Chakera, Roope Männikkö, Kashyap A. Patel

Publikováno v: Diabetologia

Aims/hypothesis The finding that patients with diabetes due to potassium channel mutations can transfer from insulin to sulfonylureas has revolutionised the management of patients with permanent neonatal diabetes. The extent to which the in vitro cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e9c5c14481acf68a28fc73bd69d1bb
https://doi.org/10.1007/s00125-016-3921-8