Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Natascia Guida"'
Autor:
Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background REST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits Na+/Ca2+exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on brain promoter (Br) after stroke. We identified a new putative RE1 site i
Externí odkaz:
https://doaj.org/article/368c7c109bcc45fdb6e0e75da03f5e5d
Autor:
Ornella Cuomo, Pasquale Cepparulo, Serenella Anzilotti, Angelo Serani, Rossana Sirabella, Paola Brancaccio, Natascia Guida, Valeria Valsecchi, Antonio Vinciguerra, Pasquale Molinaro, Luigi Formisano, Lucio Annunziato, Giuseppe Pignataro, MD PhD
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 1063-1071 (2019)
It has been demonstrated that the K+-dependent Na+/Ca2+ exchanger, NCKX2, is a new promising stroke neuroprotective target. However, because no pharmacological activator of NCKX2 is still available, microRNA (miRNA) may represent an alternative metho
Externí odkaz:
https://doaj.org/article/d5de7584c93d4d1a9c8576dbbe4a279e
Autor:
Serenella Anzilotti, Valeria Valsecchi, Paola Brancaccio, Natascia Guida, Giusy Laudati, Valentina Tedeschi, Tiziana Petrozziello, Francesco Frecentese, Elisa Magli, Brenda Hassler, Ornella Cuomo, Luigi Formisano, Agnese Secondo, Lucio Annunziato, Giuseppe Pignataro
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105480- (2021)
Imbalance in cellular ionic homeostasis is a hallmark of several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS). Sodium-calcium exchanger (NCX) is a membrane antiporter that, operating in a bidirectional way, couples the exc
Externí odkaz:
https://doaj.org/article/c110849e8ae54092b396ebb8f78a7eb8
Autor:
Natascia Guida, Luca Sanguigno, Luigi Mascolo, Lucrezia Calabrese, Angelo Serani, Pasquale Molinaro, C. Geoffrey Lau, Lucio Annunziato, Luigi Formisano
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (RES
Externí odkaz:
https://doaj.org/article/89a302f1e8e84e34bd6a9666029f77d1
Autor:
Valeria de Rosa, Agnese Secondo, Anna Pannaccione, Roselia Ciccone, Luigi Formisano, Natascia Guida, Roberta Crispino, Annalisa Fico, Roman Polishchuk, Antimo D'Aniello, Lucio Annunziato, Francesca Boscia
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-21 (2018)
Abstract Glutamate signaling may orchestrate oligodendrocyte precursor cell (OPC) development and myelin regeneration through the activation of glutamate receptors at OPC‐neuron synapses. D‐Aspartate is a D‐amino acid exerting modulatory action
Externí odkaz:
https://doaj.org/article/283ac96cde994a9db662834ea0c9d13e
Autor:
Rossana Sirabella, Valeria Valsecchi, Serenella Anzilotti, Ornella Cuomo, Antonio Vinciguerra, Pasquale Cepparulo, Paola Brancaccio, Natascia Guida, Nicolas Blondeau, Lorella M. T. Canzoniero, Cristina Franco, Salvatore Amoroso, Lucio Annunziato, Giuseppe Pignataro
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Amyotrophic lateral sclerosis (ALS) is one of the most threatening neurodegenerative disease since it causes muscular paralysis for the loss of Motor Neurons in the spinal cord, brainstem and motor cortex. Up until now, no effective pharmacological t
Externí odkaz:
https://doaj.org/article/6ebd4e2ad47e4257bc7f4c4263b4c7eb
Autor:
Luigi Formisano, Natascia Guida, Valeria Valsecchi, Giuseppe Pignataro, Antonio Vinciguerra, Anna Pannaccione, Agnese Secondo, Francesca Boscia, Pasquale Molinaro, Maria Jose Sisalli, Rossana Sirabella, Antonella Casamassa, Lorella M.T. Canzoniero, Gianfranco Di Renzo, Lucio Annunziato
Publikováno v:
Neurobiology of Disease, Vol 50, Iss , Pp 76-85 (2013)
The Na+–Ca2+ exchanger 1 (NCX1), a bidirectional transporter that mediates the electrogenic exchange of one calcium ion for three sodium ions across the plasmamembrane, is known to be involved in brain ischemia. Since the RE1-silencing transcriptio
Externí odkaz:
https://doaj.org/article/71cab51d5cb34e53a92f400340fb6f14
Autor:
Luca Sanguigno, Natascia Guida, Serenella Anzilotti, Ornella Cuomo, Luigi Mascolo, Angelo Serani, Paola Brancaccio, Giuseppina Pennacchio, Ester Licastro, Giuseppe Pignataro, Pasquale Molinaro, Lucio Annunziato, Luigi Formisano
Publikováno v:
International Journal of Biological Sciences. 19:2695-2710
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e7a78bd37a8c98d2fc6ba0e30de8c3
https://doi.org/10.7150/ijbs.80735
https://doi.org/10.7150/ijbs.80735
Autor:
Giuseppe Pignataro, Natascia Guida, Luigi Formisano, Paola Brancaccio, Serenella Anzilotti, Ornella Cuomo, Pasquale Molinaro, Lucio Annunziato, Angelo Serani, Luigi Mascolo
Publikováno v:
Stroke. 52:3680-3691
Background and Purpose: NCX3 (Na + -Ca 2+ exchanger 3) plays a relevant role in stroke; indeed its pharmacological blockade or its genetic ablation exacerbates brain ischemic damage, whereas its upregulation takes part in the neuroprotection elicited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd56b0fe015c1cc2a05a59697a6687f
https://doi.org/10.1161/strokeaha.121.034637
https://doi.org/10.1161/strokeaha.121.034637
Autor:
Natascia Guida, Lucio Annunziato, Giuseppe Pignataro, Giusy Laudati, Serenella Anzilotti, Paola Brancaccio, Ornella Cuomo, Angelo Serani, Valeria Valsecchi
Publikováno v:
Mol Ther
Spinal muscular atrophy (SMA) is a severe neuromuscular disease affecting infants caused by alterations of the survival motor neuron gene, which results in progressive degeneration of motor neurons (MNs). Although an effective treatment for SMA patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e80042a778bca5a0543b0352b6aaeb
https://doi.org/10.1016/j.ymthe.2020.01.013
https://doi.org/10.1016/j.ymthe.2020.01.013