Výsledky vyhledávání - "Natascha Vidovic"

Akademický článek

A Custom Panel for Profiling Microglia Gene Expression

Autor: Phani Sankar Potru, Natascha Vidovic, Susanne Wiemann, Tamara Russ, Marcel Trautmann, Björn Spittau

Publikováno v: Cells, Vol 13, Iss 7, p 630 (2024)

Despite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders. Recent advancements in single-cell

Externí odkaz: https://doaj.org/article/d081256819bb4bcfa11933a1d457b73a

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Akademický článek

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.

Autor: Hans Dieter Nischalke, Cordula Berger, Carolin Luda, Thomas Berg, Tobias Müller, Frank Grünhage, Frank Lammert, Martin Coenen, Benjamin Krämer, Christian Körner, Natascha Vidovic, Johannes Oldenburg, Jacob Nattermann, Tilman Sauerbruch, Ulrich Spengler

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27087 (2011)

BackgroundAn isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism

Externí odkaz: https://doaj.org/article/7eb1b9d661c04ff89accb593ab8daa1b

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Effects of a Multimerized Recombinant Autoantibody Against Amyloid-β

Autor: Alexandra Albus, Hendrik van der Wurp, Philipp Kuhn, Natascha Vidovic, Tamar Ziehm, Sascha Neumann, André Frenzel, Yannick Kronimus, Marc Seifert, Richard Dodel

Publikováno v: Neuroscience. 463:355-369

Alzheimer's disease (AD) is the most common neurodegenerative disease; thus, the search for a cure or causal therapy has become necessary. Despite intense research on this topic in recent decades, there is no curative therapy up today, and also no di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f39031c0b7f9b8295bf7ca939620f4
https://doi.org/10.1016/j.neuroscience.2021.03.006

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The neuroprotective role of microglial cells against amyloid beta-mediated toxicity in organotypic hippocampal slice cultures

Autor: Natascha Vidovic, Richard Dodel, Knut Biber, Maren Richter, Amalia M. Dolga, Carsten Culmsee

Publikováno v: Brain Pathology
BRAIN PATHOLOGY, 30(3), 589-602. Wiley-Blackwell

During Alzheimer’s disease (AD) progression, microglial cells play complex roles and have potentially detrimental as well as beneficial effects. The use of appropriate model systems is essential for characterizing and understanding the roles of mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7196951e69fa916dbb24eb6ba37000ae
https://www.ncbi.nlm.nih.gov/pubmed/31769564

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Activation of SK2 channels preserves ER Ca2+ homeostasis and protects against ER stress-induced cell death

Autor: Carsten Culmsee, Birgit Honrath, Maren Richter, Amalia M. Dolga, Natascha Vidovic, Richard Dodel, P Mahavadi

Publikováno v: Cell death and differentiation, 23, 814-827. Nature Publishing Group

Alteration of endoplasmic reticulum (ER) Ca(2+) homeostasis leads to excessive cytosolic Ca(2+) accumulation and delayed neuronal cell death in acute and chronic neurodegenerative disorders. While our recent studies established a protective role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8319d9b988eb264b3c4f244a21a166
https://doi.org/10.1038/cdd.2015.146

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Prophylaxis and quality of life in patients with hemophilia A during routine treatment with ADVATE [antihemophilic factor (recombinant), plasma/albumin-free method] in Germany: a subgroup analysis of the ADVATE PASS post-approval, non-interventional study

Autor: J. Epstein, Gerald Spotts, Robert Klamroth, H. Pollmann, Natascha Vidovic, Ingo Abraham, Alexander Y. Kriukov, Johannes Oldenburg

Publikováno v: Annals of Hematology. 92:689-698

Antihemophilic factor (recombinant), plasma/albumin-free method (rAHF-PFM) was evaluated during routine practice in Germany, among consenting subjects of any age with hemophilia A (HA) and no prior exposure to rAHF-PFM. The treating physician chose t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a18034a0dfeb7e7c34b1c0abb672b
https://doi.org/10.1007/s00277-013-1678-4

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The relevance of the bleeding severity in the treatment of acquired haemophilia - an update of a single-centre experience with 67 patients

Autor: Johannes Oldenburg, Hans-Hermann Brackmann, Natascha Vidovic, Heike Zeitler, Gudrun Ulrich-Merzenich, Georg Goldmann

Publikováno v: Haemophilia. 16:95-101

Summary. Acquired haemophilia (AH), an autoimmune disorder with clinical features ranging from harmless haematomas to life-threatening bleedings, still has a mortality rate of up to 25%. Owing to its low frequency (1–4 × 106), standardized treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8061a6c65bd611ccdc29eb61f0750a74
https://doi.org/10.1111/j.1365-2516.2008.01922.x

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Extracorporeal Treatment for the Acute und Long-Term Outcome of Patients with Life-Threatening Acquired Hemophilia

Autor: D Panek, Johannes Oldenburg, Natascha Vidovic, Georg Goldmann, Hans-Hermann Brackmann, Gudrun Ulrich-Merzenich, Heike Zeitler

OBJECTIVES: In acquired hemophilia (AH), autoantibodies (inhibitors) impede blood coagulation factors leading to severe bleedings. Cornerstones of a successful treatment are the control of bleeding and an eradication of autoantibodies. The present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52051fba8f83cd804e59c82e26d184bc
https://europepmc.org/articles/PMC3434332/

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The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis

Autor: Ulrich Spengler, Thomas Berg, Benjamin Krämer, Frank Lammert, Jacob Nattermann, Tobias Müller, Hans Dieter Nischalke, Christian Körner, Cordula Berger, Carolin Luda, Frank Grünhage, Tilman Sauerbruch, Natascha Vidovic, Johannes Oldenburg, Martin Coenen

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27087 (2011)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe6cf11406b4613b65603614086989c
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22087248/pdf/?tool=EBI

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Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C

Autor: Natascha Vidovic, Tilman Sauerbruch, S. Arndt, Bettina Langhans, Ulrich Spengler, I. Braunschweiger, Wibke Schulte, Laura E. Layland, Johannes Oldenburg, Judith Satoguina, Achim Hoerauf

Publikováno v: Clinical science (London, England : 1979). 119(2)

CD4+ Treg-cells (regulatory T-cells) probably contribute to the impaired virus-specific T-cell responses in chronic HCV (hepatitis C virus) infection; however, their antigen-specificity has remained elusive. In the present study, we analysed peripher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210ad4d156b573bb7f334f02ab78c065
https://pubmed.ncbi.nlm.nih.gov/20222873

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