Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Natascha Pfeiffer"'
Autor:
Christiane Brandwein, Cathalijn H.C. Leenaars, Laura Becker, Natascha Pfeiffer, Ana-Maria Iorgu, Melissa Hahn, Gaia A. Vairani, Lars Lewejohann, André Bleich, Anne S. Mallien, Peter Gass
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106917- (2023)
As depression is projected to become the leading mental disease burden globally by 2030, understanding the underlying pathology, as well as screening potential anti-depressants with a higher efficacy, faster onset of action, and/or fewer side-effects
Externí odkaz:
https://doaj.org/article/0fd7811df4754f24849ecd19164f9ef6
Autor:
Laura Becker, Anne S Mallien, Natascha Pfeiffer, Christiane Brandwein, Steven R Talbot, André Bleich, Rupert Palme, Heidrun Potschka, Peter Gass
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292816 (2023)
The forced swim test (FST) is a traditional assay, which has been used for more than 40 years to assess antidepressant effects of novel drug candidates. In recent years, a debate about the test has focused on the assumption that the FST is highly ave
Externí odkaz:
https://doaj.org/article/d0a41a9fa8a446cd87944b726af88fec
Autor:
Anne Stephanie Mallien, Laura Becker, Natascha Pfeiffer, Federica Terraneo, Melissa Hahn, Anthonieke Middelman, Rupert Palme, Kerstin Camile Creutzberg, Veronica Begni, Marco Andrea Riva, Damiana Leo, Heidrun Potschka, Fabio Fumagalli, Judith R. Homberg, Peter Gass
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain used in p
Externí odkaz:
https://doaj.org/article/f01fe0dd64c74543a7a97544fd93975b
Autor:
Anne Stephanie Mallien, Natascha Pfeiffer, Christiane Brandwein, Dragos Inta, Rolf Sprengel, Rupert Palme, Steven R. Talbot, Peter Gass
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
The use of animals in neurosciences is pivotal to gaining insights into complex functions and dysfunctions of behavior. For example, various forms of physical and/or psychological stress are inherent to various animal models for psychiatric disorders
Externí odkaz:
https://doaj.org/article/3fb3e2b81b11489b9b661ae5ea7290bb
Autor:
Anne S. Mallien, Natascha Pfeiffer, Miriam A. Vogt, Sabine Chourbaji, Rolf Sprengel, Peter Gass, Dragos Inta
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence. On the other hand, pha
Externí odkaz:
https://doaj.org/article/19540137975f4814a24a3945dde269df
Autor:
Veronica Begni, Alice Sanson, Natascha Pfeiffer, Christiane Brandwein, Dragos Inta, Steven R Talbot, Marco Andrea Riva, Peter Gass, Anne Stephanie Mallien
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0248070 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0240439.].
Externí odkaz:
https://doaj.org/article/73d4c34285ae4a7fb7f1870c7b5391c1
Autor:
Veronica Begni, Alice Sanson, Natascha Pfeiffer, Christiane Brandwein, Dragos Inta, Steven R Talbot, Marco Andrea Riva, Peter Gass, Anne Stephanie Mallien
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240439 (2020)
Early life stress compromises brain development and can contribute to the development of mental illnesses. A common animal model used to study different facets of psychiatric disorders is social isolation from early life on. In rats, this isolation c
Externí odkaz:
https://doaj.org/article/fb90cef96edd458da025ba2f8145b39c
Autor:
Sabine Chourbaji, Carolin Hoyer, S Helene Richter, Christiane Brandwein, Natascha Pfeiffer, Miriam A Vogt, Barbara Vollmayr, Peter Gass
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19218 (2011)
Depressive episodes are frequently preceded by stressful life events. Evidence from genetic association studies suggests a role for the glucocorticoid receptor (GR), an essential element in the regulation of stress responses, in the pathophysiology o
Externí odkaz:
https://doaj.org/article/dcc79ae148ad4f8db5cf886c5b847a52
Autor:
Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E Lang, Dragos Inta, Peter Gass
Publikováno v:
International Journal of Neuropsychopharmacology. 25:946-950
Summary Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f59ffdaff55a79c3a82f81a3809172c
https://doi.org/10.1093/ijnp/pyac051
https://doi.org/10.1093/ijnp/pyac051
Autor:
Peter Gass, Natascha Pfeiffer, Dragos Inta, Undine E. Lang, Andrei-Nicolae Vasilescu, Anne S. Mallien
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 271:1587-1591
Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ae4c20d0d12e8828dcee90430f4345
https://doi.org/10.1007/s00406-020-01180-5
https://doi.org/10.1007/s00406-020-01180-5