The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Autor: Mark H. Ellisman, Daniela Boassa, Susan S. Taylor, Alexandr P. Kornev, Sven H. Schmidt, Natascha Mumdey, Friedrich W. Herberg, Matthias J. Knape

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 30
Proceedings of the National Academy of Sciences of the United States of America

Significance Little is known about the regulation of Leucine-rich repeat kinase 2 (LRRK2) associated with familial Parkinson’s disease (PD). To test whether the kinase domain drives LRRK2 activation, we applied the spine concept that describes the

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https://escholarship.org/uc/item/2wj7c9h7