Filopodia rotate and coil by actively generating twist in their actin shaft

Autor: Natascha Leijnse, Younes Farhangi Barooji, Mohammad Reza Arastoo, Stine Lauritzen Sønder, Bram Verhagen, Lena Wullkopf, Janine Terra Erler, Szabolcs Semsey, Jesper Nylandsted, Lene Broeng Oddershede, Amin Doostmohammadi, Poul Martin Bendix

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The authors show how tubular surface structures in all cell types, have the ability to twist and perform rotary sweeping motion to explore the extracellular environment. This has implications for migration, sensing and cell communication.

Externí odkaz: https://doaj.org/article/3b19980656f94b5e89838b8bd1184075

Differential elasticity in lineage segregation of embryonic stem cells

Autor: Christine M. Ritter, Natascha Leijnse, Younes Farhangi Barooji, Joshua M. Brickman, Amin Doostmohammadi, Lene B. Oddershede

The question of what guides lineage segregation is central to development, where cellular differentiation leads to segregated cell populations destined for specialized functions. Here, using optical tweezers measurements of mouse embryonic stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d632713a054a05c65d01f6537a6ac4ba
http://arxiv.org/abs/2209.09707

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

Autor: Ann Katrine V. West, Janine T. Erler, Chris D. Madsen, Lene B. Oddershede, Thomas R. Cox, Natascha Leijnse, Lena Wullkopf

Publikováno v: Wullkopf, L, West, A K V, Leijnse, N, Cox, T R, Madsen, C D, Oddershede, L B & Erler, J T 2018, ' Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential ', Molecular Biology of the Cell, vol. 29, no. 20, pp. 2378-2385 . https://doi.org/10.1091/mbc.E18-05-0319
Molecular Biology of the Cell

Increased tissue stiffness is a classic characteristic of solid tumors. One of the major contributing factors is increased density of collagen fibers in the extracellular matrix (ECM). Here, we investigate how cancer cells biomechanically interact wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcaa83c75477db623405c95de08b2f5b
https://doi.org/10.1091/mbc.e18-05-0319

An updated look at actin dynamics in filopodia

Autor: Lene B. Oddershede, Poul Martin Bendix, Natascha Leijnse

Publikováno v: Cytoskeleton. 72:71-79

Cells dynamically interact with and probe their environment by growing finger-like structures named filopodia. The dynamics of filopodia are mainly caused by the actin rich core or shaft which sits inside the filopodial membrane and continuously unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b277100ec867d43bd039325851f78033
https://doi.org/10.1002/cm.21216

Dynamics of cancerous tissue correlates with invasiveness

Autor: Natascha Leijnse, Lena Wullkopf, Ann-Katrine Vransø West, Janine T. Erler, Jens M. Tarp, Joachim Mathiesen, Amalie Christensen, Lene B. Oddershede

Publikováno v: West, A-K V, Wullkopf, L, Christensen, A, Leijnse, N, Tarp, J M, Mathiesen, J, Erler, J T & Oddershede, L B 2017, ' Dynamics of cancerous tissue correlates with invasiveness ', Scientific Reports, vol. 7, 43800 . https://doi.org/10.1038/srep43800
Scientific Reports

Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2eb603ce26c06dc6715e866c236b12
https://doi.org/10.1038/srep43800