Výsledky vyhledávání - "Natascha K. A. Grzimek"

A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum

Autor: Judith Müller, Torsten Däubner, Niels A. W. Lemmermann, Stefan Tenzer, Annette Fink, Christof K. Seckert, Matthias J. Reddehase, Claudia Janssen, Arne Seitz, Silke A. Oehrlein-Karpi, Natascha K. A. Grzimek, Stefan Ebert, Angélique Renzaho, Christian O. Simon, Dennis Strand

Publikováno v: Journal of General Virology. 91:1524-1534

Gene m164 of murine cytomegalovirus belongs to the large group of 'private' genes that show no homology to those of other cytomegalovirus species and are thought to represent 'host adaptation' genes involved in virus-host interaction. Previous intere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b8b8754fa7c17174cb9648746a8d35
https://doi.org/10.1099/vir.0.018580-0

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Synergism between the components of the bipartite major immediate-early transcriptional enhancer of murine cytomegalovirus does not accelerate virus replication in cell culture and host tissues

Autor: Jürgen Podlech, Annette Fink, Kai A. Kropp, Matthias J. Reddehase, Birgit Kühnapfel, Natascha K. A. Grzimek, Angélique Renzaho, Christian O. Simon

Publikováno v: Journal of General Virology. 90:2395-2401

Major immediate-early (MIE) transcriptional enhancers of cytomegaloviruses are key regulators that are regarded as determinants of virus replicative fitness and pathogenicity. The MIE locus of murine cytomegalovirus (mCMV) shows bidirectional gene-pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4389ac485e37f56597956ad946e459
https://doi.org/10.1099/vir.0.012245-0

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Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

Autor: Matthias J. Reddehase, Natascha K. A. Grzimek, Christof K. Seckert, Angélique Renzaho

Publikováno v: Medical Microbiology and Immunology. 197:251-259

Hematopoietic stem cell transplantation (HSCT) bears a risk of reactivating latent cytomegalovirus (CMV) in either the transplanted hematopoietic donor cells or in parenchymal and stromal tissue cells of the immunocompromised recipient, or in both. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ff07f7ea1547377dc6e4413765c3ae
https://doi.org/10.1007/s00430-008-0094-1

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Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

Autor: Jürgen Podlech, Marcus-Folker Pahl-Seibert, Niels A. W. Lemmermann, Matthias J. Reddehase, Rafaela Holtappels, Silke A. Oehrlein-Karpi, Verena Böhm, Doris Thomas, Petra Deegen, Natascha K. A. Grzimek

Publikováno v: Medical Microbiology and Immunology. 197:135-144

Preclinical research in murine models as well as subsequent clinical trials have concordantly revealed a high protective potential of antiviral CD8 T cells, of donor-derived ex vivo memory CD8 T cells in particular, in the immunotherapy of cytomegalo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca39877e86f58ef2cc5e4ffb0c48d42
https://doi.org/10.1007/s00430-008-0092-3

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Murine Cytomegalovirus Major Immediate-Early Enhancer Region Operating as a Genetic Switch in Bidirectional Gene Pair Transcription

Autor: Matthias J. Reddehase, Natascha K. A. Grzimek, Birgit Kühnapfel, Christian O. Simon

Publikováno v: Journal of Virology. 81:7805-7810

Enhancers are defined as DNA elements that increase transcription when placed in any orientation relative to a promoter. The major immediate-early (MIE) enhancer region of murine cytomegalovirus is flanked by transcription units ie1/3 and ie2 , which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01b8eae40c60ddd33bbc9376c841a32
https://doi.org/10.1128/jvi.02388-06

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CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation

Autor: Christian O. Simon, Silke A. Oehrlein-Karpi, Dennis Strand, Torsten Däubner, Rafaela Holtappels, Hanna-Mari Tervo, Verena Böhm, Natascha K. A. Grzimek, Angélique Renzaho, Matthias J. Reddehase, Jürgen Podlech, Birgit Kühnapfel

Publikováno v: Journal of Virology. 80:10436-10456

During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes of desilencing lead to the expression of IE1 transcripts. This low-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002a3fd0d2657d86919bf11558be05f4
https://doi.org/10.1128/jvi.01248-06

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Role for Tumor Necrosis Factor Alpha in Murine Cytomegalovirus Transcriptional Reactivation in Latently Infected Lungs

Autor: Doris Dreis, Christian O. Simon, Christof K. Seckert, Natascha K. A. Grzimek, Matthias J. Reddehase

Publikováno v: Journal of Virology. 79:326-340

Interstitial pneumonia is a major clinical manifestation of primary or recurrent cytomegalovirus (CMV) infection in immunocompromised recipients of a bone marrow transplant. In a murine model, lungs were identified as a prominent site of CMV latency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9747114090a145c1bc8cbb21e7595ff3
https://doi.org/10.1128/jvi.79.1.326-340.2005

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Early gene m18, a novel player in the immune response to murine cytomegalovirus

Autor: Doris Thomas, Matthias J. Reddehase, Rafaela Holtappels, Natascha K. A. Grzimek

Publikováno v: Journal of General Virology. 83:311-316

The identification of all antigenic peptides encoded by a pathogen, its T cell ‘immunome’, is a research aim for rational vaccine design. Screening of proteome-spanning peptide libraries or computational prediction is used to identify antigenic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dea7edfdae8937fdf82342b1b722c3
https://doi.org/10.1099/0022-1317-83-2-311

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Experimental Preemptive Immunotherapy of Murine Cytomegalovirus Disease with CD8 T-Cell Lines Specific for ppM83 and pM84, the Two Homologs of Human Cytomegalovirus Tegument Protein ppUL83 (pp65)

Autor: Natascha K. A. Grzimek, Doris Thomas, Matthias J. Reddehase, Marcus-Folker Pahl-Seibert, Rafaela Holtappels, Jürgen Podlech

Publikováno v: Journal of Virology. 75:6584-6600

CD8 T cells are the principal antiviral effectors controlling cytomegalovirus (CMV) infection. For human CMV, the virion tegument protein ppUL83 (pp65) has been identified as a source of immunodominant peptides and is regarded as a candidate for cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbc55753dc7657393cb182a1424f6cf
https://doi.org/10.1128/jvi.75.14.6584-6600.2001

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In Vivo Replication of Recombinant Murine Cytomegalovirus Driven by the Paralogous Major Immediate-Early Promoter-Enhancer of Human Cytomegalovirus

Autor: Rafaela Holtappels, Matthias J. Reddehase, Jürgen Podlech, Susanne Schmalz, Hans-Peter Steffens, Natascha K. A. Grzimek

Publikováno v: Journal of Virology. 73:5043-5055

Transcription of the major immediate-early (MIE) genes of cytomegaloviruses (CMV) is driven by a strong promoter-enhancer (MIEPE) complex. Transactivator proteins encoded by these MIE genes are essential for productive infection. Accordingly, the MIE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcb35174724594c02d0045bec74229e
https://doi.org/10.1128/jvi.73.6.5043-5055.1999

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