Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Natascha A. Wolff"'
Autor:
Natascha A. Wolff, Michael D. Garrick, Lin Zhao, Laura M. Garrick, Andrew J. Ghio, Frank Thévenod
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that the divalent metal transporter 1
Externí odkaz:
https://doaj.org/article/c28f4d75b2874b9d9cddc1e25c2f7f68
Autor:
Natascha A. Wolff, Yohannes Hagos
Publikováno v:
Toxins, Vol 2, Iss 8, Pp 2055-2082 (2010)
In the present review we have attempted to assess the involvement of the organic anion transporters OAT1, OAT2, OAT3, and OAT4, belonging to the SLC22 family of polyspecific carriers, in drug-induced renal damage in humans. We have focused on drugs w
Externí odkaz:
https://doaj.org/article/f04acf80e1be4c8c85de23afd551e9d3
Autor:
Rachel P. L. van Swelm, Frank Thévenod, Natascha A. Wolff, Bettina Scharner, Stephanie Probst, Wing-Kee Lee, Eleni Roussa, Johannes Fels
Publikováno v:
Archives of Toxicology, 95, 2719-2735
Archives of Toxicology
Archives of Toxicology, 95, 8, pp. 2719-2735
Archives of Toxicology
Archives of Toxicology, 95, 8, pp. 2719-2735
The liver hormone hepcidin regulates systemic iron homeostasis. Hepcidin is also expressed by the kidney, but exclusively in distal nephron segments. Several studies suggest hepcidin protects against kidney damage involving Fe2+ overload. The nephrot
Autor:
Stephanie Probst, C. Langelueddecke, Frank Thévenod, Wing-Kee Lee, R. Betten, Bettina Scharner, B. Edemir, Natascha A. Wolff
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-20 (2018)
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-20 (2018)
Background We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonica
Autor:
Lin Zhao, Laura M. Garrick, Michael D. Garrick, Natascha A. Wolff, Frank Thévenod, Andrew J. Ghio
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that the divalent metal transporter 1 (DMT1) i
Publikováno v:
Channels. 8:458-466
The divalent metal transporter (DMT1) is well known for its roles in duodenal iron absorption across the apical enterocyte membrane, in iron efflux from the endosome during transferrin-dependent cellular iron acquisition, as well as in uptake of non-
Publikováno v:
Toxicology. 330:41-43
Autor:
Frank Thévenod, Irina Schatz, Thorsten Keller, Giuliano Ciarimboli, Rouvier Al-Monajjed, Hermann Koepsell, Natascha A. Wolff, Valentin Gorboulev, Wing-Kee Lee, Marcus Leistner
Publikováno v:
Molecular Pharmaceutics. 10:3045-3056
Polyspecific organic cation transporter Oct2 from rat (gene Slc22A2) has been previously shown to transport Cs(+). Here we report that human OCT2 (hOCT2) is able to transport Cd(2+) showing substrate saturation with a Michaelis-Menten constant (Km) o
Autor:
Frank Thévenod, Natascha A. Wolff
Publikováno v:
Metallomics : integrated biometal science. 8(1)
The kidney has recently emerged as an organ with a significant role in systemic iron (Fe) homeostasis. Substantial amounts of Fe are filtered by the kidney, which have to be reabsorbed to prevent Fe deficiency. Accordingly Fe transporters and recepto
Publikováno v:
Current Drug Metabolism. 10:617-631
The polyspecific organic cation transporters OCT1 (SLC22A1), OCT2 (SLC22A2) and OCT3 (SLC22A3) mediate facilitated and bidirectional diffusion of small (or = 500Da) organic cations with broad specificities for endogenous substrates such as choline, a