Fluorinated PLGA-PEG-Mannose Nanoparticles for Tumor-Associated Macrophage Detection by Optical Imaging and MRI

Autor: Giorgia Zambito, Siyuan Deng, Joost Haeck, Natasa Gaspar, Uwe Himmelreich, Roberta Censi, Clemens Löwik, Piera Di Martino, Laura Mezzanotte

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Tumor-associated macrophages (TAMs) promote cancer growth and metastasis, but their role in tumor development needs to be fully understood due to the dynamic changes of tumor microenvironment (TME). Here, we report an approach to visualize TAMs by op

Externí odkaz: https://doaj.org/article/4f227a9a207c40e39d4159e458eeda96

Monitoring Immune Cell Function Through Optical Imaging

Autor: Laura Mezzanotte, Roisin McMorrow, Natasa Gaspar, Giorgia Zambito, Chintan Chawda

Publikováno v: Molecular Imaging and Biology

Transgenic mouse models have facilitated research of human diseases and validation of therapeutic approaches. Inclusion of optical reporter genes (fluorescent or bioluminescent genes) in the targeting vectors used to develop such models makes in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d347d0a8f4320b429ac7ccb8fbe84475
http://www.scopus.com/inward/record.url?scp=85118588173&partnerID=8YFLogxK

Red-shifted click beetle luciferase mutant expands the multicolor bioluminescent palette for deep tissue imaging

Autor: Laura Mezzanotte, Clemens W G M Löwik, Lance P. Encell, Mary P. Hall, Yanto Ridwan, Natasa Gaspar, Thomas A. Kirkland, Giorgia Zambito, Ce Shi, Monika G. Wood, Fabio Stellari

Publikováno v: iScience, Vol 24, Iss 1, Pp 101986-(2021)
iScience, 24(1):101986. Elsevier Inc.
iScience

Summary For in vivo multicolor bioluminescence applications, red and near-infrared signals are desirable over shorter wavelength signals because they are not as susceptible to light attenuation by blood and tissue. Herein, we describe the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c731d4b4f43a2205793c7291a1082b83
http://www.sciencedirect.com/science/article/pii/S2589004220311834

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

Autor: Lance P. Encell, Ce Shi, Thomas A. Kirkland, Laura Mezzanotte, Yanto Ridwan, Natasa Gaspar, Mary P. Hall, Giorgia Zambito, Clemens W G M Löwik

Publikováno v: Molecular Imaging and Biology
Molecular imaging and biology, vol. 22, no. 6, pp. 1523-1531
Molecular Imaging and Biology, 22(6), 1523-1531. Springer New York

Purpose Currently, a variety of red and green beetle luciferase variants are available for bioluminescence imaging (BLI). In addition, new luciferin analogues providing longer wavelength luminescence have been developed that show promise for improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f257c84847710ec3615df0a322dbdc9