Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Natasa Cmiljanovic"'
Autor:
Filip Janku, Grace M. Choong, Mateusz Opyrchal, Afshin Dowlati, Cinta Hierro, Jordi Rodon, Andreas Wicki, Martin D. Forster, Sarah P. Blagden, Jun Yin, Joel M. Reid, Helene Muller, Natasa Cmiljanovic, Vladimir Cmiljanovic, Alex A. Adjei
Publikováno v:
Cancers, Vol 16, Iss 6, p 1137 (2024)
Background: Bimiralisib is a pan-PI3K/mTOR inhibitor demonstrating antitumor efficacy in preclinical models. The objectives of this study were to identify a maximum tolerated dose (MTD), pharmacokinetics (PK), a dosing schedule, and adverse events (A
Externí odkaz:
https://doaj.org/article/dc11e6bb219149eea8c74e000a1fc021
Autor:
Nicolas Munz, Luciano Cascione, Luca Parmigiani, Chiara Tarantelli, Andrea Rinaldi, Natasa Cmiljanovic, Vladimir Cmiljanovic, Rosalba Giugno, Francesco Bertoni, Sara Napoli
Publikováno v:
Non-Coding RNA, Vol 7, Iss 2, p 26 (2021)
Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to q
Externí odkaz:
https://doaj.org/article/5b5be392e2c347158754b46f11f2dfa0
Autor:
Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Buparlisib/BKM120 is in phase 3 clinical trials as a phosphoinositide 3-kinase (PI3K) inhibitor. Here, Bohnackeret al. combine chemical biology and structural biology approaches to segregate BKM120’s biological actions, and suggest that it causes m
Externí odkaz:
https://doaj.org/article/a5212909a4a7490db4d79600c172c822
Autor:
NATASA CMILJANOVIC, SVETLANA MILOSAVLJEVIC, SLAVKO RADENKOVIC, DRAGAN STEVANOVIC, IVAN GUTMAN
Publikováno v:
Journal of the Serbian Chemical Society, Vol 69, Iss 10, Pp 777-782 (2004)
Using a recently developed method for computing the effect of non-bonding molecular orbitals (NBMOs) on the total p-electron energy (E), it was found that the dependence of E on the number n0 of NBMOs is almost perfectly linear. We now show that this
Externí odkaz:
https://doaj.org/article/3c6b8e5440914ceb8977eff7ca02af31
Autor:
Rosalba Giugno, Luca Parmigiani, Andrea Rinaldi, Nicolas Munz, Chiara Tarantelli, Natasa Cmiljanovic, Sara Napoli, Vladimir Cmiljanovic, Luciano Cascione, Francesco Bertoni
Publikováno v:
Non-Coding RNA
Volume 7
Issue 2
Non-Coding RNA, Vol 7, Iss 26, p 26 (2021)
Volume 7
Issue 2
Non-Coding RNA, Vol 7, Iss 26, p 26 (2021)
Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to q
Autor:
Roger von Moos, Michael Stumm, Vincent Prêtre, Cinta Hierro, Alexandar Tzankov, Vincent Bize, Sasa Dimitrijevic, Viviane Hess, Cristiana Sessa, Reto Ritschard, Jordi Rodon, Richard Herrmann, Alexa Childs, Vladimir Cmiljanovic, Simona Berardi, Rebecca Kristeleit, Nicholas F. Brown, Markus Joerger, Andreas Wicki, A. Xyrafas, Hanne Hawle, D. Hess, Natasa Cmiljanovic
Publikováno v:
European Journal of Cancer. 96:6-16
Background PQR309 is an orally bioavailable, balanced pan-phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) C1 and mTORC2 inhibitor. Patients and methods This is an accelerated titration, 3 + 3 dose-escalation, open-label pha
Autor:
Dragan Stevanović, Svetlana Milosavljević, Slavko Radenković, Natasa Cmiljanovic, Ivan Gutman
Publikováno v:
Journal of the Serbian Chemical Society, Vol 69, Iss 10, Pp 777-782 (2004)
Using a recently developed method for computing the effect of non-bonding molecular orbitals (NBMOs) on the total ?-electron energy (E), it was found that the dependence of E on the number n0 of NBMOs is almost perfectly linear. We now show that this
Publikováno v:
Chemical Physics Letters. 383:171-175
The presence of non-bonding molecular orbitals diminishes the HMO total π-electron energy. A method is elaborated to quantitatively assess this effect. The effect is found to be much smaller than earlier anticipated. Contrary to earlier claims, it d
Autor:
Florent Beaufils, Natasa Cmiljanovic, Paul Hebeisen, W. Dieterle, Vladimir Cmiljanovic, S. Dimitrijević, Matthias P. Wymann, R. Ettlin, M. Stumm, Doriano Fabbro, Petra Hillmann, Bernd Giese
Publikováno v:
Toxicology Letters. 238:S337-S338
Autor:
Rebecca Kristeleit, Andreas Wicki, Natasa Cmiljanovic, Deborah Schmitz, Vincent Bize, Nicholas S. Brown, Michael Stumm, Reto Ritschard, Sasa Dimitrijevic, Vincent Prêtre, Thomas Fabbro
Publikováno v:
Cancer Research. 76:2287-2287
Background: PQR309 is a novel, oral, balanced pan-class 1 PI3K, mTORC1 and mTORC2 inhibitor. PQR309-001 was a first-in-man dose escalation study evaluating PQR309 in patients with advanced solid tumours. The primary objective of the study was to esta